Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892675562> ?p ?o ?g. }
- W2892675562 abstract "The specific organization of the neuronal microtubule cytoskeleton in axons and dendrites is an evolutionarily conserved determinant of neuronal polarity, allowing for selective cargo sorting. However, how dendritic microtubules are organized and whether local differences influence cargo transport remains largely unknown. Here, we use live-cell imaging to systematically probe the microtubule organization in C. elegans neurons and demonstrate the contribution of distinct mechanisms in the organization of dendritic microtubules. We found that most non-ciliated neurons depend on unc-116 (kinesin-1), unc-33 (CRMP) and unc-44 (ankyrin) for proper microtubule organization and polarized cargo transport, as previously reported. Ciliated neurons and the URX neuron however, use an additional pathway to nucleate microtubules from the tip of the dendrite, at the base of the sensory cilium in ciliated neurons. Since, inhibition of distal microtubule nucleation affects distal dendritic transport, we propose a model in which the presence of a microtubule organizing center at the dendrite tip ensures proper dendritic cargo transport." @default.
- W2892675562 created "2018-10-05" @default.
- W2892675562 creator A5006471870 @default.
- W2892675562 creator A5023829602 @default.
- W2892675562 creator A5025164063 @default.
- W2892675562 creator A5025511346 @default.
- W2892675562 creator A5046582662 @default.
- W2892675562 creator A5058356091 @default.
- W2892675562 creator A5064387290 @default.
- W2892675562 creator A5084050629 @default.
- W2892675562 date "2018-01-01" @default.
- W2892675562 modified "2023-09-28" @default.
- W2892675562 title "Local microtubule organization promotes cargo transport in <i>C. elegans</i> dendrites" @default.
- W2892675562 cites W1521011562 @default.
- W2892675562 cites W1666768116 @default.
- W2892675562 cites W1846293222 @default.
- W2892675562 cites W1905036343 @default.
- W2892675562 cites W1912876688 @default.
- W2892675562 cites W1978009498 @default.
- W2892675562 cites W1985602726 @default.
- W2892675562 cites W1989783465 @default.
- W2892675562 cites W1990211095 @default.
- W2892675562 cites W1992497015 @default.
- W2892675562 cites W1993552170 @default.
- W2892675562 cites W1996635457 @default.
- W2892675562 cites W1997122736 @default.
- W2892675562 cites W2017351619 @default.
- W2892675562 cites W2018557177 @default.
- W2892675562 cites W2019255889 @default.
- W2892675562 cites W2026750744 @default.
- W2892675562 cites W2027771004 @default.
- W2892675562 cites W2029355706 @default.
- W2892675562 cites W2035219498 @default.
- W2892675562 cites W2038232460 @default.
- W2892675562 cites W2049455196 @default.
- W2892675562 cites W2055323321 @default.
- W2892675562 cites W2057430295 @default.
- W2892675562 cites W2059155214 @default.
- W2892675562 cites W2060297895 @default.
- W2892675562 cites W2074393382 @default.
- W2892675562 cites W2079458003 @default.
- W2892675562 cites W2080391158 @default.
- W2892675562 cites W2087895896 @default.
- W2892675562 cites W2089681380 @default.
- W2892675562 cites W2095436637 @default.
- W2892675562 cites W2098540980 @default.
- W2892675562 cites W2099228538 @default.
- W2892675562 cites W2102905759 @default.
- W2892675562 cites W2110318878 @default.
- W2892675562 cites W2113144687 @default.
- W2892675562 cites W2116469093 @default.
- W2892675562 cites W2121206498 @default.
- W2892675562 cites W2122684024 @default.
- W2892675562 cites W2134467496 @default.
- W2892675562 cites W2140341433 @default.
- W2892675562 cites W2141151381 @default.
- W2892675562 cites W2146512122 @default.
- W2892675562 cites W2156434975 @default.
- W2892675562 cites W2160749505 @default.
- W2892675562 cites W2182809622 @default.
- W2892675562 cites W2188534067 @default.
- W2892675562 cites W2191269904 @default.
- W2892675562 cites W2277743976 @default.
- W2892675562 cites W2336101489 @default.
- W2892675562 cites W2338064835 @default.
- W2892675562 cites W2465604414 @default.
- W2892675562 cites W2502130428 @default.
- W2892675562 cites W2539080302 @default.
- W2892675562 cites W2606022871 @default.
- W2892675562 cites W2606376354 @default.
- W2892675562 cites W2606833132 @default.
- W2892675562 cites W2607434928 @default.
- W2892675562 cites W2625130610 @default.
- W2892675562 cites W2739097098 @default.
- W2892675562 cites W2771928043 @default.
- W2892675562 doi "https://doi.org/10.1242/jcs.223107" @default.
- W2892675562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6215390" @default.
- W2892675562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30254025" @default.
- W2892675562 hasPublicationYear "2018" @default.
- W2892675562 type Work @default.
- W2892675562 sameAs 2892675562 @default.
- W2892675562 citedByCount "52" @default.
- W2892675562 countsByYear W28926755622019 @default.
- W2892675562 countsByYear W28926755622020 @default.
- W2892675562 countsByYear W28926755622021 @default.
- W2892675562 countsByYear W28926755622022 @default.
- W2892675562 countsByYear W28926755622023 @default.
- W2892675562 crossrefType "journal-article" @default.
- W2892675562 hasAuthorship W2892675562A5006471870 @default.
- W2892675562 hasAuthorship W2892675562A5023829602 @default.
- W2892675562 hasAuthorship W2892675562A5025164063 @default.
- W2892675562 hasAuthorship W2892675562A5025511346 @default.
- W2892675562 hasAuthorship W2892675562A5046582662 @default.
- W2892675562 hasAuthorship W2892675562A5058356091 @default.
- W2892675562 hasAuthorship W2892675562A5064387290 @default.
- W2892675562 hasAuthorship W2892675562A5084050629 @default.
- W2892675562 hasBestOaLocation W28926755621 @default.
- W2892675562 hasConcept C100094513 @default.
- W2892675562 hasConcept C10447061 @default.
- W2892675562 hasConcept C104672736 @default.