Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892679989> ?p ?o ?g. }
- W2892679989 endingPage "1312" @default.
- W2892679989 startingPage "1306" @default.
- W2892679989 abstract "The crystal structure of UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase; WbpP; EC 5.1.3.7), from the archaeal methanogen Methanobrevibacter ruminantium strain M1, was determined to a resolution of 1.65 Å. The structure, with a single monomer in the crystallographic asymmetric unit, contained a conserved N-terminal Rossmann-fold for nucleotide binding and an active site positioned in the C-terminus. UDP-GlcNAc 4-epimerase is a member of the short-chain dehydrogenases/reductases superfamily, sharing sequence motifs and structural elements characteristic of this family of oxidoreductases and bacterial 4-epimerases. The protein was co-crystallized with coenzyme NADH and UDP-N-acetylmuramic acid, the latter an unintended inclusion and well known product of the bacterial enzyme MurB and a critical intermediate for bacterial cell wall synthesis. This is a non-native UDP sugar amongst archaea and was most likely incorporated from the E. coli expression host during purification of the recombinant enzyme." @default.
- W2892679989 created "2018-10-05" @default.
- W2892679989 creator A5008741587 @default.
- W2892679989 creator A5016270372 @default.
- W2892679989 creator A5027851081 @default.
- W2892679989 creator A5040688787 @default.
- W2892679989 creator A5063444827 @default.
- W2892679989 date "2018-10-05" @default.
- W2892679989 modified "2023-09-26" @default.
- W2892679989 title "Structural determination of archaeal UDP‐ N ‐acetylglucosamine 4‐epimerase from Methanobrevibacter ruminantium M1 in complex with the bacterial cell wall intermediate UDP‐ N ‐acetylmuramic acid" @default.
- W2892679989 cites W1270023315 @default.
- W2892679989 cites W1684334462 @default.
- W2892679989 cites W170549476 @default.
- W2892679989 cites W1892158199 @default.
- W2892679989 cites W1947962930 @default.
- W2892679989 cites W1965501888 @default.
- W2892679989 cites W1970635130 @default.
- W2892679989 cites W1984751161 @default.
- W2892679989 cites W1988331437 @default.
- W2892679989 cites W1994522551 @default.
- W2892679989 cites W1998536115 @default.
- W2892679989 cites W2002170620 @default.
- W2892679989 cites W2007735611 @default.
- W2892679989 cites W2013455102 @default.
- W2892679989 cites W2013943856 @default.
- W2892679989 cites W2017979796 @default.
- W2892679989 cites W2028720241 @default.
- W2892679989 cites W2032145697 @default.
- W2892679989 cites W2038840577 @default.
- W2892679989 cites W2040952692 @default.
- W2892679989 cites W2052542617 @default.
- W2892679989 cites W2073451508 @default.
- W2892679989 cites W2076400489 @default.
- W2892679989 cites W2078000524 @default.
- W2892679989 cites W2080329840 @default.
- W2892679989 cites W2080740016 @default.
- W2892679989 cites W2086098074 @default.
- W2892679989 cites W2089752219 @default.
- W2892679989 cites W2090378229 @default.
- W2892679989 cites W2098627421 @default.
- W2892679989 cites W2105999876 @default.
- W2892679989 cites W2106527927 @default.
- W2892679989 cites W2110035145 @default.
- W2892679989 cites W2110256992 @default.
- W2892679989 cites W2116473078 @default.
- W2892679989 cites W2127414589 @default.
- W2892679989 cites W2129188087 @default.
- W2892679989 cites W2137240337 @default.
- W2892679989 cites W2137489399 @default.
- W2892679989 cites W2144059760 @default.
- W2892679989 cites W2144081223 @default.
- W2892679989 cites W2147874841 @default.
- W2892679989 cites W2151393821 @default.
- W2892679989 cites W2160288046 @default.
- W2892679989 cites W2163341755 @default.
- W2892679989 cites W2169320500 @default.
- W2892679989 cites W2435401553 @default.
- W2892679989 cites W4210675630 @default.
- W2892679989 cites W4240895940 @default.
- W2892679989 cites W4249040368 @default.
- W2892679989 cites W77588596 @default.
- W2892679989 cites W815498662 @default.
- W2892679989 doi "https://doi.org/10.1002/prot.25606" @default.
- W2892679989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30242905" @default.
- W2892679989 hasPublicationYear "2018" @default.
- W2892679989 type Work @default.
- W2892679989 sameAs 2892679989 @default.
- W2892679989 citedByCount "8" @default.
- W2892679989 countsByYear W28926799892019 @default.
- W2892679989 countsByYear W28926799892020 @default.
- W2892679989 countsByYear W28926799892021 @default.
- W2892679989 countsByYear W28926799892022 @default.
- W2892679989 crossrefType "journal-article" @default.
- W2892679989 hasAuthorship W2892679989A5008741587 @default.
- W2892679989 hasAuthorship W2892679989A5016270372 @default.
- W2892679989 hasAuthorship W2892679989A5027851081 @default.
- W2892679989 hasAuthorship W2892679989A5040688787 @default.
- W2892679989 hasAuthorship W2892679989A5063444827 @default.
- W2892679989 hasBestOaLocation W28926799892 @default.
- W2892679989 hasConcept C104317684 @default.
- W2892679989 hasConcept C167625842 @default.
- W2892679989 hasConcept C181199279 @default.
- W2892679989 hasConcept C19655278 @default.
- W2892679989 hasConcept C2777438225 @default.
- W2892679989 hasConcept C45484198 @default.
- W2892679989 hasConcept C523546767 @default.
- W2892679989 hasConcept C54355233 @default.
- W2892679989 hasConcept C550995028 @default.
- W2892679989 hasConcept C55493867 @default.
- W2892679989 hasConcept C86803240 @default.
- W2892679989 hasConceptScore W2892679989C104317684 @default.
- W2892679989 hasConceptScore W2892679989C167625842 @default.
- W2892679989 hasConceptScore W2892679989C181199279 @default.
- W2892679989 hasConceptScore W2892679989C19655278 @default.
- W2892679989 hasConceptScore W2892679989C2777438225 @default.
- W2892679989 hasConceptScore W2892679989C45484198 @default.
- W2892679989 hasConceptScore W2892679989C523546767 @default.
- W2892679989 hasConceptScore W2892679989C54355233 @default.