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• W2892693999 abstract "Background: This study consisted of 60 randomly selected patients (49 men and 11women) who had undergone both symptom-limited treadmill exercise tests andcoronary angiography, within one month, for clinical indications. This was a prospectivestudy done during the period of December 1998 to July 1999 in NICVD, DhakaBangladesh. The ECG is generally considered to provide a summation of the electricalactivity of the heart and to be insensitive to local electrophysiological events. Recentstudies suggest that important local electrophysiological differences can be detectedfrom a standard 12 -lead ECG, allowing new insights into the electrical behavior ofpatient’s hearts. The QT dispersion recorded as the difference between maximumand minimum QT intervals on a 12-lead ECG, is sensitive to myocardial ischaemiaand may improve the accuracy of exercise testing.Methods and Results: Exercise ECGs were analyzed in 60 patients who had undergoneexercise ECG and coronary angiography for clinical indications:1) The true-positive (TP) group consisted of 22 patients with mean ±SD age of 52 ± 9years. These patients had a positive treadmill test result with ³1 mm horizontal STsegmentdepression and an abnormal coronary angiogram, defined as ³ 50% diameterstenosis of a major epicardial coronary artery. Two patients were female in this group.2) The true negative (TN) group consisted of 20 patients who had a negative exercisetest and non significant CAD based on coronary angiography. The mean ± SD age ofthe group was 44 ± 8 years. Five patients were female in this group.3) Eight patients with positive treadmill test result with abnormal exercise ECGs andnon significant coronary artery disease (False positive [FP] group). This group had amean age of 43± 10 years. Three patients were female in this group.4) The false negative (FN) group consisted of 10 patients with mean ±SD age of 48± 7years. These patients had negative exercise ECG and an abnormal coronary angiogram.This group had one female patient.The exercise QTD Was 41±14ms in TN, 78±22ms in TP (P<0.001 versus TP) and47±16ms in FP (P=NS versus TN and P< 0.001 versus TP) groups. The exercise QTDwas 84±17ms in FN (P=NS versus TP) group.A stress QTD of >60ms had a sensitivity of 88% and specificity of 93% for the diagnosisof significant CAD compared with 68% (P<0.05) and 71% (P<0.01) respectively, for³ 1mm ST-segment depression during stress. When QTD of >60ms was added to STsegmentdepression as a condition for positive test, the specificity increased to 100%.Conclusion: Exercise QTD is an easily measurable ECG variable that significantlyincreases the accuracy of exercise testing.Key Words: QT dispersion . coronary disease . electrocardiography . exercise." @default.
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• W2892693999 date "2003-01-01" @default.
• W2892693999 modified "2023-09-27" @default.
• W2892693999 title "Significance of Qt Dispersion to Improve the Diagnostic Accuracy of Exercise Stress Tests for Myocardial Ischaemia" @default.
• W2892693999 doi "https://doi.org/10.31729/jnma.849" @default.
• W2892693999 hasPublicationYear "2003" @default.
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