FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892694129> ?p ?o ?g. }

• W2892694129 endingPage "284" @default.
• W2892694129 startingPage "277" @default.
• W2892694129 abstract "Abstract Context DICER1 syndrome is a rare autosomal-dominantly inherited disorder that predisposes to a variety of cancerous and noncancerous tumors of mostly pediatric and adolescent onset, including differentiated thyroid carcinoma (DTC). DTC has been hypothesized to arise secondarily to the increased prevalence of thyroid hyperplastic nodules in syndromic patients. Objective To determine somatic alterations in DICER1-associated DTC and to study patient outcomes. Design Retrospective series. Setting Tertiary referral centers. Patients Ten patients with germline pathogenic DICER1 variants and early-onset DTC. Methods Somatic DICER1 mutation analysis, extensive somatic DNA variant and gene fusion analyses were performed on all tumors. Results Median age at DTC diagnosis was 13.5 years and there was no recurrent or metastatic disease (median follow-up, 8 years). All thyroid specimens showed diffuse nodular hyperplasia with at least one focus suspicious of DTC but without infiltrative growth, extrathyroidal extension, vascular invasion, or lymph node metastasis. Most of the individual nodules (benign and malignant) sampled from the 10 tumors harbored distinct DICER1 RNase IIIb hotspot mutations, indicating a polyclonal composition of each tumor. Furthermore, nine of 10 DICER1-related DTCs lacked well-known oncogenic driver DNA variants and gene rearrangements. Conclusion On the basis of our clinical, histological, and molecular data, we consider that most DICER1-related DTCs form a low-risk subgroup. These tumors may arise within one of multiple benign monoclonal nodules; thus, hemi-thyroidectomy or, more likely, total thyroidectomy may often be required. However, radioiodine treatment may be unnecessary given the patients’ ages and the tumors’ low propensity for metastases." @default.
• W2892694129 created "2018-10-05" @default.
• W2892694129 creator A5016129566 @default.
• W2892694129 creator A5019642492 @default.
• W2892694129 creator A5020507879 @default.
• W2892694129 creator A5029874203 @default.
• W2892694129 creator A5033039461 @default.
• W2892694129 creator A5033225491 @default.
• W2892694129 creator A5034512606 @default.
• W2892694129 creator A5073914742 @default.
• W2892694129 creator A5076361972 @default.
• W2892694129 creator A5083605347 @default.
• W2892694129 creator A5083885781 @default.
• W2892694129 date "2018-09-26" @default.
• W2892694129 modified "2023-09-27" @default.
• W2892694129 title "Clinical and Molecular Characteristics May Alter Treatment Strategies of Thyroid Malignancies in DICER1 Syndrome" @default.
• W2892694129 cites W1481990366 @default.
• W2892694129 cites W1667088041 @default.
• W2892694129 cites W1711683526 @default.
• W2892694129 cites W1834952683 @default.
• W2892694129 cites W1848939527 @default.
• W2892694129 cites W1948291609 @default.
• W2892694129 cites W1964103231 @default.
• W2892694129 cites W2006718597 @default.
• W2892694129 cites W2007159304 @default.
• W2892694129 cites W2008945738 @default.
• W2892694129 cites W2051568696 @default.
• W2892694129 cites W2052101095 @default.
• W2892694129 cites W2058430812 @default.
• W2892694129 cites W2059993793 @default.
• W2892694129 cites W2078630829 @default.
• W2892694129 cites W2084402496 @default.
• W2892694129 cites W2097403264 @default.
• W2892694129 cites W2128071925 @default.
• W2892694129 cites W2143002495 @default.
• W2892694129 cites W2144038313 @default.
• W2892694129 cites W2147706645 @default.
• W2892694129 cites W2149848115 @default.
• W2892694129 cites W2180354914 @default.
• W2892694129 cites W2202015706 @default.
• W2892694129 cites W2223462212 @default.
• W2892694129 cites W2269494669 @default.
• W2892694129 cites W2297375919 @default.
• W2892694129 cites W2297417946 @default.
• W2892694129 cites W2314815360 @default.
• W2892694129 cites W2337882641 @default.
• W2892694129 cites W2400942920 @default.
• W2892694129 cites W2400990240 @default.
• W2892694129 cites W2502986684 @default.
• W2892694129 cites W2527050229 @default.
• W2892694129 cites W2528945565 @default.
• W2892694129 cites W2591407779 @default.
• W2892694129 cites W2610547404 @default.
• W2892694129 cites W2768641780 @default.
• W2892694129 cites W2782939356 @default.
• W2892694129 cites W2791073610 @default.
• W2892694129 cites W2791082958 @default.
• W2892694129 cites W2793048289 @default.
• W2892694129 doi "https://doi.org/10.1210/jc.2018-00774" @default.
• W2892694129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30260442" @default.
• W2892694129 hasPublicationYear "2018" @default.
• W2892694129 type Work @default.
• W2892694129 sameAs 2892694129 @default.
• W2892694129 citedByCount "20" @default.
• W2892694129 countsByYear W28926941292019 @default.
• W2892694129 countsByYear W28926941292020 @default.
• W2892694129 countsByYear W28926941292021 @default.
• W2892694129 countsByYear W28926941292022 @default.
• W2892694129 countsByYear W28926941292023 @default.
• W2892694129 crossrefType "journal-article" @default.
• W2892694129 hasAuthorship W2892694129A5016129566 @default.
• W2892694129 hasAuthorship W2892694129A5019642492 @default.
• W2892694129 hasAuthorship W2892694129A5020507879 @default.
• W2892694129 hasAuthorship W2892694129A5029874203 @default.
• W2892694129 hasAuthorship W2892694129A5033039461 @default.
• W2892694129 hasAuthorship W2892694129A5033225491 @default.
• W2892694129 hasAuthorship W2892694129A5034512606 @default.
• W2892694129 hasAuthorship W2892694129A5073914742 @default.
• W2892694129 hasAuthorship W2892694129A5076361972 @default.
• W2892694129 hasAuthorship W2892694129A5083605347 @default.
• W2892694129 hasAuthorship W2892694129A5083885781 @default.
• W2892694129 hasBestOaLocation W28926941291 @default.
• W2892694129 hasConcept C104317684 @default.
• W2892694129 hasConcept C126322002 @default.
• W2892694129 hasConcept C13514818 @default.
• W2892694129 hasConcept C142724271 @default.
• W2892694129 hasConcept C143998085 @default.
• W2892694129 hasConcept C151730666 @default.
• W2892694129 hasConcept C167135981 @default.
• W2892694129 hasConcept C2777074255 @default.
• W2892694129 hasConcept C2779022025 @default.
• W2892694129 hasConcept C2779343474 @default.
• W2892694129 hasConcept C2779761222 @default.
• W2892694129 hasConcept C2993294228 @default.
• W2892694129 hasConcept C501734568 @default.
• W2892694129 hasConcept C526584372 @default.
• W2892694129 hasConcept C54355233 @default.
• W2892694129 hasConcept C71924100 @default.

• next