Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892697024> ?p ?o ?g. }
- W2892697024 abstract "Abstract The weak immunogenicity of gliomas presents a barrier for effective immunotherapy. Na/H exchanger isoform 1 (NHE1) maintains alkaline intracellular pH (pH i ) of glioma cells and acidic microenvironment. In addition, NHE1 is expressed in tumor-associated microglia and tumor-associated macrophages (TAMs) and involved in protumoral communications between glioma and TAMs. Therefore, we hypothesize that NHE1 plays a role in developing tumor resistance and immunosuppressive tumor microenvironment. In this study, we investigated the efficacy of pharmacological inhibition of NHE1 on combinatorial therapies. Here we show that temozolomide (TMZ) treatment stimulates NHE1 protein expression in two intracranial syngeneic mouse glioma models (SB28, GL26). Pharmacological inhibition of NHE1 potentiated the cytotoxic effects of TMZ, leading to reduced tumor growth and increased median survival of mice. Blockade of NHE1 stimulated proinflammatory activation of TAM and increased cytotoxic T cell infiltration into tumors. Combining TMZ, anti-PD-1 antibody treatment with NHE1 blockade significantly prolonged the median survival in the mouse glioma model. These results demonstrate that pharmacological inhibition of NHE1 protein presents a new strategy for potentiating TMZ-induced cytotoxicity and increasing tumor immunogenicity for immunotherapy to improve glioma therapy." @default.
- W2892697024 created "2018-10-05" @default.
- W2892697024 creator A5009370574 @default.
- W2892697024 creator A5022169733 @default.
- W2892697024 creator A5036236379 @default.
- W2892697024 creator A5041148128 @default.
- W2892697024 creator A5047233885 @default.
- W2892697024 creator A5047438878 @default.
- W2892697024 creator A5049938481 @default.
- W2892697024 creator A5076047973 @default.
- W2892697024 creator A5082902582 @default.
- W2892697024 creator A5086872650 @default.
- W2892697024 date "2018-09-27" @default.
- W2892697024 modified "2023-10-12" @default.
- W2892697024 title "Blockade of Na/H exchanger stimulates glioma tumor immunogenicity and enhances combinatorial TMZ and anti-PD-1 therapy" @default.
- W2892697024 cites W1574172480 @default.
- W2892697024 cites W1753190777 @default.
- W2892697024 cites W1921451985 @default.
- W2892697024 cites W1966273336 @default.
- W2892697024 cites W1966422114 @default.
- W2892697024 cites W1975198903 @default.
- W2892697024 cites W1976840830 @default.
- W2892697024 cites W1984278612 @default.
- W2892697024 cites W1990590292 @default.
- W2892697024 cites W1992496728 @default.
- W2892697024 cites W2005096273 @default.
- W2892697024 cites W2009803740 @default.
- W2892697024 cites W2019154144 @default.
- W2892697024 cites W2021006094 @default.
- W2892697024 cites W2044528599 @default.
- W2892697024 cites W2044597300 @default.
- W2892697024 cites W2053471606 @default.
- W2892697024 cites W2055708923 @default.
- W2892697024 cites W2060070314 @default.
- W2892697024 cites W2062928140 @default.
- W2892697024 cites W2066379425 @default.
- W2892697024 cites W2068050569 @default.
- W2892697024 cites W2073880277 @default.
- W2892697024 cites W2074841206 @default.
- W2892697024 cites W2092409918 @default.
- W2892697024 cites W2096555449 @default.
- W2892697024 cites W2097259163 @default.
- W2892697024 cites W2097694520 @default.
- W2892697024 cites W2101015190 @default.
- W2892697024 cites W2102074004 @default.
- W2892697024 cites W2106210866 @default.
- W2892697024 cites W2117399686 @default.
- W2892697024 cites W2119785056 @default.
- W2892697024 cites W2121795796 @default.
- W2892697024 cites W2127745150 @default.
- W2892697024 cites W2133508691 @default.
- W2892697024 cites W2158681922 @default.
- W2892697024 cites W2164899913 @default.
- W2892697024 cites W2165200432 @default.
- W2892697024 cites W2165871546 @default.
- W2892697024 cites W2220215167 @default.
- W2892697024 cites W2223535266 @default.
- W2892697024 cites W2243854106 @default.
- W2892697024 cites W2269473200 @default.
- W2892697024 cites W2294927533 @default.
- W2892697024 cites W2295059886 @default.
- W2892697024 cites W2303158491 @default.
- W2892697024 cites W2327002369 @default.
- W2892697024 cites W2335226483 @default.
- W2892697024 cites W2336770942 @default.
- W2892697024 cites W2338428112 @default.
- W2892697024 cites W2366536035 @default.
- W2892697024 cites W2411750282 @default.
- W2892697024 cites W2495102879 @default.
- W2892697024 cites W2552210919 @default.
- W2892697024 cites W2565874663 @default.
- W2892697024 cites W2588896788 @default.
- W2892697024 cites W2594788664 @default.
- W2892697024 cites W2595863515 @default.
- W2892697024 cites W2596054013 @default.
- W2892697024 cites W2613340520 @default.
- W2892697024 cites W2749747068 @default.
- W2892697024 cites W2774878811 @default.
- W2892697024 cites W2804663253 @default.
- W2892697024 cites W2805359783 @default.
- W2892697024 cites W2810333172 @default.
- W2892697024 cites W4211107382 @default.
- W2892697024 doi "https://doi.org/10.1038/s41419-018-1062-3" @default.
- W2892697024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6160445" @default.
- W2892697024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30262908" @default.
- W2892697024 hasPublicationYear "2018" @default.
- W2892697024 type Work @default.
- W2892697024 sameAs 2892697024 @default.
- W2892697024 citedByCount "42" @default.
- W2892697024 countsByYear W28926970242018 @default.
- W2892697024 countsByYear W28926970242019 @default.
- W2892697024 countsByYear W28926970242020 @default.
- W2892697024 countsByYear W28926970242021 @default.
- W2892697024 countsByYear W28926970242022 @default.
- W2892697024 countsByYear W28926970242023 @default.
- W2892697024 crossrefType "journal-article" @default.
- W2892697024 hasAuthorship W2892697024A5009370574 @default.
- W2892697024 hasAuthorship W2892697024A5022169733 @default.
- W2892697024 hasAuthorship W2892697024A5036236379 @default.
- W2892697024 hasAuthorship W2892697024A5041148128 @default.