FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892698549> ?p ?o ?g. }

• W2892698549 abstract "Cataract, the leading cause of blindness, is currently treated only by surgery. Cataract carries risk of complications and its management increases economic burden. Thus, development of pharmacological options with anticataract effects is important. Oxidative-nitrosative stress, non-enzymatic glycation and osmotic stress underlie cataractogenesis. Since tocotrienol possesses biological properties that may suppress pathophysiological mechanism of cataractogenesis, we investigated its anticataract effects in rats. Tocotrienol was formulated into two widely used colloidal drug delivery systems, microemulsion and liposome, due to its poor aqueous solubility. Firstly, the dose-dependent effects of microemulsion of tocotrienol on cataractogenesis were studied in galactose-fed rats to determine the most effective dose of tocotrienol. Different concentrations of tocotrienol were applied topically twice daily from three weeks prior to galactose diet and continued for four weeks along with galactose diet. Cataract progression was monitored and after euthanization, lenticular oxidative stress was measured. Subsequently, using the most effective dose, anticataract efficacy of microemulsion and liposomal formulation was compared in galactose-fed rats. Additionally, ocular tissue distribution of a lipophilic dye using these formulations was studied. For this distribution study, single drop of solution or formulation containing lipophilic dye was applied and animals were euthanized at different time points. Eyeglobes were dissected, cryosectioned, viewed under confocal microscope and analyzed. Lastly, mechanisms of anticataract effect of tocotrienol were studied in the rat model of streptozotocin-induced diabetes, which is a closer representation of human diabetic cataract. Using this model, the effects of tocotrienol on lenticular polyol pathway, oxidative and nitrosative stress, NFKB signaling pathway, ATP and ATPase content, calpain activity and proteins levels were studied. In dose-response study, 0.03 and 0.02% tocotrienol-treated groups showed slower cataract progression compared to vehicle-treated animals with reduction of lenticular oxidative stress. Faster cataract progression and higher oxidative stress were seen in rats treated with higher concentration of tocotrienol compared to vehicle-treated group. Both microemulsion and liposomal formulations showed similar anticataract efficacy. In ocular distribution study, better intraocular distribution was observed following single drop application of lipophilic dye in microemulsion compared to liposome and solution. In rats with streptozotocin-induced diabetes, tocotrienol delayed the progression of cataract and this anticataract effect was associated with reduction of lenticular oxidative-nitrosative stress, NFKB activation, iNOS expression, lens polyol levels, and restoration of the ATP and ATPase levels, calpain activity and lens protein levels. In conclusion, topically applied tocotrienol shows anticataract effects in rats by reducing oxidative-nitrosative stress and restoring the lens polyol levels, ATP and ATPase levels, calpain activity and lens protein levels." @default.
• W2892698549 created "2018-10-05" @default.
• W2892698549 creator A5023036997 @default.
• W2892698549 creator A5055396925 @default.
• W2892698549 date "2016-01-01" @default.
• W2892698549 modified "2023-09-29" @default.
• W2892698549 title "Studies to elucidate mechanisms underlying the anticataract effect of annatto tocotrienol in rats / Nurul Alimah Abdul Nasir" @default.
• W2892698549 hasPublicationYear "2016" @default.
• W2892698549 type Work @default.
• W2892698549 sameAs 2892698549 @default.
• W2892698549 citedByCount "0" @default.
• W2892698549 crossrefType "dissertation" @default.
• W2892698549 hasAuthorship W2892698549A5023036997 @default.
• W2892698549 hasAuthorship W2892698549A5055396925 @default.
• W2892698549 hasConcept C134018914 @default.
• W2892698549 hasConcept C136502266 @default.
• W2892698549 hasConcept C147990577 @default.
• W2892698549 hasConcept C185592680 @default.
• W2892698549 hasConcept C190119865 @default.
• W2892698549 hasConcept C2776151105 @default.
• W2892698549 hasConcept C2776439734 @default.
• W2892698549 hasConcept C2777551382 @default.
• W2892698549 hasConcept C2778004101 @default.
• W2892698549 hasConcept C2778310972 @default.
• W2892698549 hasConcept C2781449162 @default.
• W2892698549 hasConcept C55493867 @default.
• W2892698549 hasConcept C555293320 @default.
• W2892698549 hasConcept C58226133 @default.
• W2892698549 hasConcept C71924100 @default.
• W2892698549 hasConcept C98274493 @default.
• W2892698549 hasConceptScore W2892698549C134018914 @default.
• W2892698549 hasConceptScore W2892698549C136502266 @default.
• W2892698549 hasConceptScore W2892698549C147990577 @default.
• W2892698549 hasConceptScore W2892698549C185592680 @default.
• W2892698549 hasConceptScore W2892698549C190119865 @default.
• W2892698549 hasConceptScore W2892698549C2776151105 @default.
• W2892698549 hasConceptScore W2892698549C2776439734 @default.
• W2892698549 hasConceptScore W2892698549C2777551382 @default.
• W2892698549 hasConceptScore W2892698549C2778004101 @default.
• W2892698549 hasConceptScore W2892698549C2778310972 @default.
• W2892698549 hasConceptScore W2892698549C2781449162 @default.
• W2892698549 hasConceptScore W2892698549C55493867 @default.
• W2892698549 hasConceptScore W2892698549C555293320 @default.
• W2892698549 hasConceptScore W2892698549C58226133 @default.
• W2892698549 hasConceptScore W2892698549C71924100 @default.
• W2892698549 hasConceptScore W2892698549C98274493 @default.
• W2892698549 hasLocation W28926985491 @default.
• W2892698549 hasOpenAccess W2892698549 @default.
• W2892698549 hasPrimaryLocation W28926985491 @default.
• W2892698549 hasRelatedWork W1981672503 @default.
• W2892698549 hasRelatedWork W1991936221 @default.
• W2892698549 hasRelatedWork W199657897 @default.
• W2892698549 hasRelatedWork W1998806662 @default.
• W2892698549 hasRelatedWork W2027303857 @default.
• W2892698549 hasRelatedWork W2053179831 @default.
• W2892698549 hasRelatedWork W2071544833 @default.
• W2892698549 hasRelatedWork W2080893569 @default.
• W2892698549 hasRelatedWork W2155343712 @default.
• W2892698549 hasRelatedWork W2159572532 @default.
• W2892698549 hasRelatedWork W2159576396 @default.
• W2892698549 hasRelatedWork W2193019846 @default.
• W2892698549 hasRelatedWork W2606887660 @default.
• W2892698549 hasRelatedWork W2780715092 @default.
• W2892698549 hasRelatedWork W2893455907 @default.
• W2892698549 hasRelatedWork W2895203143 @default.
• W2892698549 hasRelatedWork W2947506452 @default.
• W2892698549 hasRelatedWork W2953935401 @default.
• W2892698549 hasRelatedWork W3017221018 @default.
• W2892698549 hasRelatedWork W3035534766 @default.
• W2892698549 isParatext "false" @default.
• W2892698549 isRetracted "false" @default.
• W2892698549 magId "2892698549" @default.
• W2892698549 workType "dissertation" @default.