FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892698564> ?p ?o ?g. }

• W2892698564 abstract "Liver cancer is one of the most common malignant tumors worldwide. Thioredoxin reductase (TrxR) is highly expressed in liver cancer cells. The present study aimed to investigate the effect of inhibiting TrxR on liver cancer and to better understand the underlying molecular and immuno-logical mechanisms associated with inhibition. It was demonstrated that targeting TrxR inhibited the growth and induced apoptosis of liver cancer cells, which was accompanied by activation of the mitogen associated protein kinase pathway. This inhibition was dependent on the production of reactive oxygen species (ROS). Blockage of ROS production reversed TrxR inhibitor‑induced antitumor effects. Blocking the Trx/TrxR system activated the mammalian target of rapamycin pathway and inhibited autophagy, which occurred in a ROS‑independent manner. TrxR inhibition led to lesions in the mitochondrial membrane, indicated by alterations in membrane potential. Mouse xenograft experiments were highly consistent with in vitro studies. Most importantly, blocking the Trx/TrxR system improved the tumor immune microenvironment. Together, these data demonstrated that TrxR is a potential target for liver cancer therapy, which could inhibit hepatocarcinogenesis and progression, and improve the antitumor immune response." @default.
• W2892698564 created "2018-10-05" @default.
• W2892698564 creator A5033713296 @default.
• W2892698564 creator A5057209439 @default.
• W2892698564 creator A5066395209 @default.
• W2892698564 creator A5066688033 @default.
• W2892698564 date "2018-09-27" @default.
• W2892698564 modified "2023-10-02" @default.
• W2892698564 title "Inhibiting TrxR suppresses liver cancer by inducing apoptosis and eliciting potent antitumor immunity" @default.
• W2892698564 cites W1523693806 @default.
• W2892698564 cites W1576294450 @default.
• W2892698564 cites W1700829084 @default.
• W2892698564 cites W1913498273 @default.
• W2892698564 cites W1961936696 @default.
• W2892698564 cites W1970637701 @default.
• W2892698564 cites W1976153739 @default.
• W2892698564 cites W1996311090 @default.
• W2892698564 cites W2004759395 @default.
• W2892698564 cites W2043854938 @default.
• W2892698564 cites W2082047617 @default.
• W2892698564 cites W2089325545 @default.
• W2892698564 cites W2096059645 @default.
• W2892698564 cites W2107277218 @default.
• W2892698564 cites W2110942523 @default.
• W2892698564 cites W2191290620 @default.
• W2892698564 cites W2215852242 @default.
• W2892698564 cites W2312930548 @default.
• W2892698564 cites W2316022797 @default.
• W2892698564 cites W2330987887 @default.
• W2892698564 cites W2344775600 @default.
• W2892698564 cites W2411798759 @default.
• W2892698564 cites W2552377412 @default.
• W2892698564 cites W2562514953 @default.
• W2892698564 cites W2610948238 @default.
• W2892698564 cites W2709224048 @default.
• W2892698564 cites W2751891020 @default.
• W2892698564 cites W2758815794 @default.
• W2892698564 cites W2761321759 @default.
• W2892698564 cites W2767072492 @default.
• W2892698564 cites W2767426636 @default.
• W2892698564 cites W2772286407 @default.
• W2892698564 cites W2773410894 @default.
• W2892698564 cites W2774010248 @default.
• W2892698564 cites W2778879130 @default.
• W2892698564 cites W2779948368 @default.
• W2892698564 cites W386494514 @default.
• W2892698564 cites W1964184380 @default.
• W2892698564 doi "https://doi.org/10.3892/or.2018.6740" @default.
• W2892698564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6196602" @default.
• W2892698564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30272318" @default.
• W2892698564 hasPublicationYear "2018" @default.
• W2892698564 type Work @default.
• W2892698564 sameAs 2892698564 @default.
• W2892698564 citedByCount "16" @default.
• W2892698564 countsByYear W28926985642019 @default.
• W2892698564 countsByYear W28926985642020 @default.
• W2892698564 countsByYear W28926985642021 @default.
• W2892698564 countsByYear W28926985642022 @default.
• W2892698564 countsByYear W28926985642023 @default.
• W2892698564 crossrefType "journal-article" @default.
• W2892698564 hasAuthorship W2892698564A5033713296 @default.
• W2892698564 hasAuthorship W2892698564A5057209439 @default.
• W2892698564 hasAuthorship W2892698564A5066395209 @default.
• W2892698564 hasAuthorship W2892698564A5066688033 @default.
• W2892698564 hasBestOaLocation W28926985641 @default.
• W2892698564 hasConcept C121608353 @default.
• W2892698564 hasConcept C190283241 @default.
• W2892698564 hasConcept C203522944 @default.
• W2892698564 hasConcept C2776151105 @default.
• W2892698564 hasConcept C2776231280 @default.
• W2892698564 hasConcept C2777737464 @default.
• W2892698564 hasConcept C2778019345 @default.
• W2892698564 hasConcept C2781018059 @default.
• W2892698564 hasConcept C29537977 @default.
• W2892698564 hasConcept C3623737 @default.
• W2892698564 hasConcept C48349386 @default.
• W2892698564 hasConcept C502942594 @default.
• W2892698564 hasConcept C54355233 @default.
• W2892698564 hasConcept C55493867 @default.
• W2892698564 hasConcept C86803240 @default.
• W2892698564 hasConcept C95444343 @default.
• W2892698564 hasConcept C96232424 @default.
• W2892698564 hasConceptScore W2892698564C121608353 @default.
• W2892698564 hasConceptScore W2892698564C190283241 @default.
• W2892698564 hasConceptScore W2892698564C203522944 @default.
• W2892698564 hasConceptScore W2892698564C2776151105 @default.
• W2892698564 hasConceptScore W2892698564C2776231280 @default.
• W2892698564 hasConceptScore W2892698564C2777737464 @default.
• W2892698564 hasConceptScore W2892698564C2778019345 @default.
• W2892698564 hasConceptScore W2892698564C2781018059 @default.
• W2892698564 hasConceptScore W2892698564C29537977 @default.
• W2892698564 hasConceptScore W2892698564C3623737 @default.
• W2892698564 hasConceptScore W2892698564C48349386 @default.
• W2892698564 hasConceptScore W2892698564C502942594 @default.
• W2892698564 hasConceptScore W2892698564C54355233 @default.
• W2892698564 hasConceptScore W2892698564C55493867 @default.
• W2892698564 hasConceptScore W2892698564C86803240 @default.
• W2892698564 hasConceptScore W2892698564C95444343 @default.
• W2892698564 hasConceptScore W2892698564C96232424 @default.
• W2892698564 hasLocation W28926985641 @default.

• next