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- W2892702008 abstract "C-Alkylation of N-alkylamides with styrenes is reported, proceeding in ambient air/moisture to give arylbutanamides and pharmaceutically-relevant scaffolds in excellent mass balance. Various amide and styrene derivatives were tolerated, rapidly affording molecular complexity in a single step; thus highlighting the future utility of this transformation in the synthetic chemistry toolbox. Reaction scalability (up to 65 g h-1 product) was demonstrated using a Microwave Flow reactor, as the first example of a C-alkylation reaction using styrenes in continuous flow." @default.
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- W2892702008 date "2018-01-01" @default.
- W2892702008 modified "2023-10-18" @default.
- W2892702008 title "<i>C</i>-Alkylation of <i>N</i>-alkylamides with styrenes in air and scale-up using a microwave flow reactor" @default.
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- W2892702008 doi "https://doi.org/10.1039/c8ob02282h" @default.
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