FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892710148> ?p ?o ?g. }

• W2892710148 endingPage "4195" @default.
• W2892710148 startingPage "4181" @default.
• W2892710148 abstract "Carbon dioxide enters metabolism via six known CO2 fixation pathways, of which only one is linear, exergonic in the direction of CO2 -assimilation, and present in both bacterial and archaeal anaerobes - the Wood-Ljungdahl (WL) or reductive acetyl-CoA pathway. Carbon monoxide (CO) plays a central role in the WL pathway as an energy rich intermediate. Here, we scan the major biochemical reaction databases for reactions involving CO and CO2 . We identified 415 reactions corresponding to enzyme commission (EC) numbers involving CO2 , which are non-randomly distributed across different biochemical pathways. Their taxonomic distribution, reversibility under physiological conditions, cofactors and prosthetic groups are summarized. In contrast to CO2 , only 15 reaction classes involving CO were detected. Closer inspection reveals that CO interfaces with metabolism and the carbon cycle at only two enzymes: anaerobic carbon monoxide dehydrogenase (CODH), a Ni- and Fe-containing enzyme that generates CO for CO2 fixation in the WL pathway, and aerobic CODH, a Mo- and Cu-containing enzyme that oxidizes environmental CO as an electron source. The CO-dependent reaction of the WL pathway involves carbonyl insertion into a methyl carbon-nickel at the Ni-Fe-S A-cluster of acetyl-CoA synthase (ACS). It appears that no alternative mechanisms to the CO-dependent reaction of ACS have evolved in nearly 4 billion years, indicating an ancient and mechanistically essential role for CO at the onset of metabolism." @default.
• W2892710148 created "2018-10-05" @default.
• W2892710148 creator A5012890553 @default.
• W2892710148 creator A5016571082 @default.
• W2892710148 creator A5088298029 @default.
• W2892710148 date "2018-10-08" @default.
• W2892710148 modified "2023-10-16" @default.
• W2892710148 title "Something special about<scp>CO</scp>‐dependent<scp>CO</scp>₂fixation" @default.
• W2892710148 cites W1608218663 @default.
• W2892710148 cites W1637419401 @default.
• W2892710148 cites W1835011734 @default.
• W2892710148 cites W1848716311 @default.
• W2892710148 cites W1857480146 @default.
• W2892710148 cites W1947962930 @default.
• W2892710148 cites W1965187023 @default.
• W2892710148 cites W1966252600 @default.
• W2892710148 cites W1966317059 @default.
• W2892710148 cites W1968979116 @default.
• W2892710148 cites W1973012451 @default.
• W2892710148 cites W1976198069 @default.
• W2892710148 cites W1976286799 @default.
• W2892710148 cites W1979390875 @default.
• W2892710148 cites W1979804898 @default.
• W2892710148 cites W1980270634 @default.
• W2892710148 cites W1981887431 @default.
• W2892710148 cites W1983644317 @default.
• W2892710148 cites W1986606322 @default.
• W2892710148 cites W1988585005 @default.
• W2892710148 cites W1991180369 @default.
• W2892710148 cites W1992010019 @default.
• W2892710148 cites W1992994412 @default.
• W2892710148 cites W1996039824 @default.
• W2892710148 cites W1996891655 @default.
• W2892710148 cites W2010713127 @default.
• W2892710148 cites W2013061560 @default.
• W2892710148 cites W2016842763 @default.
• W2892710148 cites W2017172597 @default.
• W2892710148 cites W2022916467 @default.
• W2892710148 cites W2025118032 @default.
• W2892710148 cites W2035019866 @default.
• W2892710148 cites W2044401510 @default.
• W2892710148 cites W2045828637 @default.
• W2892710148 cites W2046287787 @default.
• W2892710148 cites W2061939602 @default.
• W2892710148 cites W2068934337 @default.
• W2892710148 cites W2079264493 @default.
• W2892710148 cites W2080730446 @default.
• W2892710148 cites W2081296920 @default.
• W2892710148 cites W2091419808 @default.
• W2892710148 cites W2098998009 @default.
• W2892710148 cites W2101488790 @default.
• W2892710148 cites W2102055688 @default.
• W2892710148 cites W2102508256 @default.
• W2892710148 cites W2103554428 @default.
• W2892710148 cites W2114450960 @default.
• W2892710148 cites W2114489683 @default.
• W2892710148 cites W2116276518 @default.
• W2892710148 cites W2116360057 @default.
• W2892710148 cites W2121411279 @default.
• W2892710148 cites W2125611981 @default.
• W2892710148 cites W2128130474 @default.
• W2892710148 cites W2128898932 @default.
• W2892710148 cites W2130107304 @default.
• W2892710148 cites W2130345130 @default.
• W2892710148 cites W2135191113 @default.
• W2892710148 cites W2137015675 @default.
• W2892710148 cites W2140860400 @default.
• W2892710148 cites W2141052558 @default.
• W2892710148 cites W2141066579 @default.
• W2892710148 cites W2141876047 @default.
• W2892710148 cites W2146576350 @default.
• W2892710148 cites W2149608854 @default.
• W2892710148 cites W2154431272 @default.
• W2892710148 cites W2165431882 @default.
• W2892710148 cites W2168722917 @default.
• W2892710148 cites W2212924810 @default.
• W2892710148 cites W2233755655 @default.
• W2892710148 cites W2246944211 @default.
• W2892710148 cites W2312986581 @default.
• W2892710148 cites W2322448011 @default.
• W2892710148 cites W2327313516 @default.
• W2892710148 cites W2359859981 @default.
• W2892710148 cites W2468352349 @default.
• W2892710148 cites W2475340364 @default.
• W2892710148 cites W2506780551 @default.
• W2892710148 cites W2527684409 @default.
• W2892710148 cites W2528917093 @default.
• W2892710148 cites W2550514660 @default.
• W2892710148 cites W2551583048 @default.
• W2892710148 cites W2555542996 @default.
• W2892710148 cites W2555587815 @default.
• W2892710148 cites W2608627859 @default.
• W2892710148 cites W2615835262 @default.
• W2892710148 cites W2783789917 @default.
• W2892710148 cites W2787022622 @default.
• W2892710148 cites W2787636346 @default.
• W2892710148 cites W2791594771 @default.
• W2892710148 cites W2793350500 @default.

• next