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- W2892715315 abstract "Background & Objective: Epilepsy is a common and serious chronic neurological disorder that is mainly treated with antiepileptic drugs. Although current antiepileptic drugs used in clinical practice have advanced to the third generation, approximately one-third of patients are refractory to these treatments. More efficacious treatments for refractory epilepsy are therefore needed. A better understanding of the mechanism underlying refractory epilepsy is likely to facilitate the development of a more effective therapy. The abnormal expression and/or dysfunction of efflux transporters, particularly ABC transporters, might contribute to certain cases of refractory epilepsy. Inflammation in the brain has recently been shown to regulate the expression and/or function of ABC transporters in the cerebral vascular endothelial cells and glia of the blood-brain barrier by activating intracellular signalling pathways. Conclusion: Therefore, in this review, we will briefly summarize recent research advances regarding the possible role of neuroinflammation in regulating ABC transporter expression in epilepsy." @default.
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- W2892715315 date "2018-11-23" @default.
- W2892715315 modified "2023-10-02" @default.
- W2892715315 title "Effect of Neuroinflammation on ABC Transporters: Possible Contribution to Refractory Epilepsy" @default.
- W2892715315 doi "https://doi.org/10.2174/1871527317666180828121820" @default.
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