FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892732016> ?p ?o ?g. }

• W2892732016 endingPage "157" @default.
• W2892732016 startingPage "146" @default.
• W2892732016 abstract "Tracheal injury, stenosis, and malignancy demand tracheal reconstruction, which often fails due to the lack of a functioning epithelium. We performed an extensive comparative analysis to determine optimal biomaterials for developing tracheal epithelial grafts with mucociliary function. We screened Hyaluronan-Poly(Ethylene Glycol), Chitosan-Collagen, Collagen Vitrigel Membrane, Fibrin Glue, Silk Fibroin, and Gelatin based on various parameters including mechanical strength, bulk degradation, cell attachment, spreading, metabolic activity, focal adhesion formation, and differentiation into ciliated and goblet cells. Silk Fibroin had significantly higher tensile strength (21.23 ± 4.42 MPa), retained 50% of its mass across 5 weeks, allowed 80–100% cell spreading and increasing metabolic activity across 10 days, focal adhesion formation within 2 h, and differentiation into 5.9 ± 2.6% goblet cells. Silk Fibroin, however, led to poor ciliation, producing 5.5 ± 3.9% ciliated cells, whereas Collagen Vitrigel Membrane promoted excellent ciliation. To capitalize on the mechanical and differentiation benefits of its respective components, we developed a composite biomaterial of Silk Fibroin and Collagen Vitrigel Membrane (SF-CVM), which demonstrated enhanced maturation into 20.6 ± 1.7% ciliated and 5.6 ± 1.0% goblet cells. Development of biomaterials-based airway epithelial grafts that provide desirable mechanics and differentiation is a major step towards treatment of airway disease. Tracheal blockage, injury, and malignancy greater than 50% of the adult tracheal length cannot be safely resected. Tracheal replacement is one approach, but a major cause of transplant failure is the lack of a functioning epithelium. While tissue engineering for tracheal regeneration using biomaterials is promising, there is currently no gold standard. Therefore, we performed a systematic comparative study to characterize relevant materials for generating a biomaterials-based airway epithelial graft. We developed a composite biomaterial intended for surgical implantation providing tensile strength, slow biodegradation, and optimal support for differentiation of mature epithelia. This is a significant step augmenting current state-of-the-art methods for airway surgeries, laryngeal reconstruction, and tracheal tissue engineering." @default.
• W2892732016 created "2018-10-05" @default.
• W2892732016 creator A5003169841 @default.
• W2892732016 creator A5020628819 @default.
• W2892732016 creator A5030295431 @default.
• W2892732016 creator A5034989730 @default.
• W2892732016 creator A5090044020 @default.
• W2892732016 date "2018-11-01" @default.
• W2892732016 modified "2023-09-25" @default.
• W2892732016 title "Optimal biomaterials for tracheal epithelial grafts: An in vitro systematic comparative analysis" @default.
• W2892732016 cites W1129870622 @default.
• W2892732016 cites W1485298061 @default.
• W2892732016 cites W1579775719 @default.
• W2892732016 cites W1918060947 @default.
• W2892732016 cites W1930345792 @default.
• W2892732016 cites W1965212355 @default.
• W2892732016 cites W1965392494 @default.
• W2892732016 cites W1968534063 @default.
• W2892732016 cites W1972212921 @default.
• W2892732016 cites W1975585910 @default.
• W2892732016 cites W1978853889 @default.
• W2892732016 cites W1979620316 @default.
• W2892732016 cites W1987777995 @default.
• W2892732016 cites W1993345096 @default.
• W2892732016 cites W1998843194 @default.
• W2892732016 cites W2010821890 @default.
• W2892732016 cites W2021029563 @default.
• W2892732016 cites W2025933216 @default.
• W2892732016 cites W2034792467 @default.
• W2892732016 cites W2035325378 @default.
• W2892732016 cites W2042049199 @default.
• W2892732016 cites W2042178588 @default.
• W2892732016 cites W2045121129 @default.
• W2892732016 cites W2046408272 @default.
• W2892732016 cites W2054988877 @default.
• W2892732016 cites W2055205318 @default.
• W2892732016 cites W2055534393 @default.
• W2892732016 cites W2056032323 @default.
• W2892732016 cites W2068305554 @default.
• W2892732016 cites W2068464011 @default.
• W2892732016 cites W2069990200 @default.
• W2892732016 cites W2073725235 @default.
• W2892732016 cites W2078752823 @default.
• W2892732016 cites W2085037298 @default.
• W2892732016 cites W2087714421 @default.
• W2892732016 cites W2093406975 @default.
• W2892732016 cites W2108160744 @default.
• W2892732016 cites W2109137926 @default.
• W2892732016 cites W2116397695 @default.
• W2892732016 cites W2129866815 @default.
• W2892732016 cites W2130318026 @default.
• W2892732016 cites W2149873896 @default.
• W2892732016 cites W2152936822 @default.
• W2892732016 cites W2156831850 @default.
• W2892732016 cites W2157908104 @default.
• W2892732016 cites W2166499316 @default.
• W2892732016 cites W2167051619 @default.
• W2892732016 cites W2168775089 @default.
• W2892732016 cites W2168844300 @default.
• W2892732016 cites W2171226607 @default.
• W2892732016 cites W2209535620 @default.
• W2892732016 cites W2323323604 @default.
• W2892732016 cites W2324067816 @default.
• W2892732016 cites W2328232201 @default.
• W2892732016 cites W2331086733 @default.
• W2892732016 cites W2335585156 @default.
• W2892732016 cites W2402956801 @default.
• W2892732016 cites W2418783344 @default.
• W2892732016 cites W2488876282 @default.
• W2892732016 cites W2512969545 @default.
• W2892732016 cites W2516087537 @default.
• W2892732016 cites W2526058697 @default.
• W2892732016 cites W2528649743 @default.
• W2892732016 cites W2578534549 @default.
• W2892732016 cites W2594273098 @default.
• W2892732016 cites W2598516749 @default.
• W2892732016 cites W2611150249 @default.
• W2892732016 cites W2622467784 @default.
• W2892732016 cites W2735826268 @default.
• W2892732016 cites W2765341240 @default.
• W2892732016 cites W2782742373 @default.
• W2892732016 cites W2794296356 @default.
• W2892732016 cites W4252299187 @default.
• W2892732016 cites W50259269 @default.
• W2892732016 doi "https://doi.org/10.1016/j.actbio.2018.09.048" @default.
• W2892732016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30268918" @default.
• W2892732016 hasPublicationYear "2018" @default.
• W2892732016 type Work @default.
• W2892732016 sameAs 2892732016 @default.
• W2892732016 citedByCount "11" @default.
• W2892732016 countsByYear W28927320162019 @default.
• W2892732016 countsByYear W28927320162020 @default.
• W2892732016 countsByYear W28927320162021 @default.
• W2892732016 countsByYear W28927320162022 @default.
• W2892732016 countsByYear W28927320162023 @default.
• W2892732016 crossrefType "journal-article" @default.
• W2892732016 hasAuthorship W2892732016A5003169841 @default.
• W2892732016 hasAuthorship W2892732016A5020628819 @default.

• next