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- W2892732274 endingPage "264" @default.
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- W2892732274 abstract "The retina is an important part of our central nervous system, and specifically, it receives light and converts it into neural signals, which are then relayed to the brain for visual processing. Furthermore, it is involved in circadian rhythms, helping regulate our sleep-wake cycle. Because of the highly metabolic nature of the retina, it can be damaged easily, resulting in a detrimental effect on daily activities. Retinal diseases, such as age-related macular degeneration and diabetic retinopathy, are the leading cause of blindness worldwide. Therapies target cellular and molecular mechanisms of these diseases but may not lead to substantial recovery of vision. Conventional therapeutic strategies are not always effective, and many patients do not recover full visual function. Nanoengineering technologies can be used in conjugation with cell-, drug-, or gene-based approaches to develop novel strategies for clinical use. In this chapter, we provide an overview of drug-, cell-, and gene-based therapies coupled with polymeric scaffolds to improve experimental strategies for retinal tissue engineering and repair. Both natural and synthetic polymers are extensively studied with the aim of their eventual use in clinical environments. Current clinical trials are summarized at the end of the chapter to raise interest in how nanoengineering technologies may be used for retinal repair and rescue." @default.
- W2892732274 created "2018-10-05" @default.
- W2892732274 creator A5017933625 @default.
- W2892732274 creator A5051350450 @default.
- W2892732274 creator A5063856556 @default.
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- W2892732274 creator A5068554873 @default.
- W2892732274 creator A5068580833 @default.
- W2892732274 creator A5074249371 @default.
- W2892732274 date "2019-01-01" @default.
- W2892732274 modified "2023-09-26" @default.
- W2892732274 title "Nanoengineered biomaterials for retinal repair" @default.
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