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• W2892739123 abstract "Aim: This study tested the hypothesis that folic acid (FA) modulates biogenic amines and protects the brain against oxidative stress induced by 3-nitropropionic acid (3NPA).Methods: Male Wistar rats received (groups of six) for 5 d: FA (50 mg/kg); 3NPA (10 mg/kg); or FA +3NPA. At last day, rats were sacrificed, and their brain was obtained to measure the levels of dopamine, 5-hydroxiindol acetic acid (5-HIAA). Reduced glutathione (GSH), total ATPase, H2O2 and lipid peroxidation were measured.Results: GSH increased significantly in cortex of rats treated with FA. ATPase increased significantly in cerebellum/medulla oblongata and decreased in cortex of animal treated with 3NPA. 5-HIAA increased in striatum of rats that received 3NPA alone or combined with FA.Conclusion: 3NPA generates free radicals such effect can be counteracted with FA administration since this folate increases antioxidant capacity and modulates biogenic amines." @default.
• W2892739123 created "2018-10-05" @default.
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• W2892739123 date "2018-09-29" @default.
• W2892739123 modified "2023-10-18" @default.
• W2892739123 title "Folic acid increases levels of GHS in brain of rats with oxidative stress induced with 3-nitropropionic acid" @default.
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• W2892739123 doi "https://doi.org/10.1080/13813455.2018.1484771" @default.
• W2892739123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30269600" @default.
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