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- W2892740100 abstract "Pregnancy represents a challenge for the maternal immune system; it has to be alert against pathogens while tolerating paternal alloantigens expressed in fetal structures and even present in the maternal circulation. A large body of evidence suggests that cells of the innate immune system are mainly involved in uterine angiogenesis and tissue remodeling, including the remodelling of uterine spiral arteries that are of vital importance for gestation. The adaptive maternal immune system is not only aware of the presence of alloantigens, but actively tolerates them to ensure the survival of the fetus. Our current understanding of pregnancy-related immune mechanisms also includes complex cell–cell interactions not only between immune cells but also between immune cells and the cells of the microenvironment at the feto-maternal interface. In addition, molecules secreted by the conceptus itself, including hormones, are able to modulate the immune system to render it tolerant towards the fetus. Disturbances in the finely modulated immune balance lead to pregnancy complications, including pre-eclampsia. ." @default.
- W2892740100 created "2018-10-05" @default.
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- W2892740100 date "2018-10-01" @default.
- W2892740100 modified "2023-09-26" @default.
- W2892740100 title "434. Immunology of pregnancy and preeclampsia" @default.
- W2892740100 doi "https://doi.org/10.1016/j.preghy.2018.08.035" @default.
- W2892740100 hasPublicationYear "2018" @default.
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