Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892743324> ?p ?o ?g. }
- W2892743324 abstract "TGF-β is a pleiotropic cytokine with multiple roles in immunity. Apart from its suppressive activity, TGF-β is a driving cytokine in the differentiation of induced regulatory T cells (iTreg) but also in the polarization of interleukin-9 (IL-9) producing T helper 9 (Th9) T cells. Human Vδ2 expressing γδ T cells exert potent cytotoxicity towards a variety of solid tumor and leukemia/lymphoma target cells and thus are in the focus of current strategies to develop cell-based immunotherapies. Here we report that TGF-β unexpectedly augments the cytotoxic effector activity of short-term expanded Vδ2 T cells when purified γδ T cells are activated with specific pyrophosphate antigens and IL-2 or IL-15 in the presence of TGF-β. TGF-β up-regulates the expression of CD54, CD103, interferon-γ, IL-9 and granzyme B in γδ T cells while CD56 and CD11a/CD18 are down-regulated. Moreover, we show that CD103 (αE/β7 integrin) is recruited to the immunological synapse in γδ T cells. Increased cytotoxic activity of TGF-β-exposed γδ T cells is reduced by anti-CD103 and further diminished upon additional anti-CD11a antibody treatment, pointing to a role of cellular adhesion in the enhanced cytolytic activity. Furthermore, magnetically sorted CD103-positive Vδ2 T cells exhibit superior cytolytic activity. In view of the importance of CD103 for tissue homing of lymphocytes, our results suggest that adoptive transfer of CD103-expressing Vδ2 T cells might favor their homing to solid tumors." @default.
- W2892743324 created "2018-10-05" @default.
- W2892743324 creator A5016937145 @default.
- W2892743324 creator A5016948656 @default.
- W2892743324 creator A5050463973 @default.
- W2892743324 creator A5052373782 @default.
- W2892743324 creator A5052876085 @default.
- W2892743324 creator A5062454800 @default.
- W2892743324 creator A5065655312 @default.
- W2892743324 creator A5074449362 @default.
- W2892743324 creator A5091618534 @default.
- W2892743324 date "2018-09-26" @default.
- W2892743324 modified "2023-09-27" @default.
- W2892743324 title "TGF-β enhances the cytotoxic activity of Vδ2 T cells" @default.
- W2892743324 cites W1107917109 @default.
- W2892743324 cites W1504591313 @default.
- W2892743324 cites W1512693074 @default.
- W2892743324 cites W1642448589 @default.
- W2892743324 cites W1692656962 @default.
- W2892743324 cites W1821802349 @default.
- W2892743324 cites W1895620535 @default.
- W2892743324 cites W1977259157 @default.
- W2892743324 cites W1991357407 @default.
- W2892743324 cites W2001114440 @default.
- W2892743324 cites W2002774826 @default.
- W2892743324 cites W2020848957 @default.
- W2892743324 cites W2024398728 @default.
- W2892743324 cites W2042155372 @default.
- W2892743324 cites W2048072477 @default.
- W2892743324 cites W2058640125 @default.
- W2892743324 cites W2066906123 @default.
- W2892743324 cites W2070935462 @default.
- W2892743324 cites W2075253497 @default.
- W2892743324 cites W2081561748 @default.
- W2892743324 cites W2103012160 @default.
- W2892743324 cites W2103288730 @default.
- W2892743324 cites W2117647921 @default.
- W2892743324 cites W2118447882 @default.
- W2892743324 cites W2127350922 @default.
- W2892743324 cites W2131014265 @default.
- W2892743324 cites W2136280424 @default.
- W2892743324 cites W2152488336 @default.
- W2892743324 cites W2156375860 @default.
- W2892743324 cites W2156802024 @default.
- W2892743324 cites W2158489327 @default.
- W2892743324 cites W2164674836 @default.
- W2892743324 cites W2168663010 @default.
- W2892743324 cites W2274843594 @default.
- W2892743324 cites W2282311837 @default.
- W2892743324 cites W2343893858 @default.
- W2892743324 cites W2469656338 @default.
- W2892743324 cites W2507863505 @default.
- W2892743324 cites W2531967896 @default.
- W2892743324 cites W2567092949 @default.
- W2892743324 cites W2734735597 @default.
- W2892743324 cites W2747454454 @default.
- W2892743324 doi "https://doi.org/10.1080/2162402x.2018.1522471" @default.
- W2892743324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6287804" @default.
- W2892743324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30546961" @default.
- W2892743324 hasPublicationYear "2018" @default.
- W2892743324 type Work @default.
- W2892743324 sameAs 2892743324 @default.
- W2892743324 citedByCount "36" @default.
- W2892743324 countsByYear W28927433242019 @default.
- W2892743324 countsByYear W28927433242020 @default.
- W2892743324 countsByYear W28927433242021 @default.
- W2892743324 countsByYear W28927433242022 @default.
- W2892743324 countsByYear W28927433242023 @default.
- W2892743324 crossrefType "journal-article" @default.
- W2892743324 hasAuthorship W2892743324A5016937145 @default.
- W2892743324 hasAuthorship W2892743324A5016948656 @default.
- W2892743324 hasAuthorship W2892743324A5050463973 @default.
- W2892743324 hasAuthorship W2892743324A5052373782 @default.
- W2892743324 hasAuthorship W2892743324A5052876085 @default.
- W2892743324 hasAuthorship W2892743324A5062454800 @default.
- W2892743324 hasAuthorship W2892743324A5065655312 @default.
- W2892743324 hasAuthorship W2892743324A5074449362 @default.
- W2892743324 hasAuthorship W2892743324A5091618534 @default.
- W2892743324 hasBestOaLocation W28927433241 @default.
- W2892743324 hasConcept C129374314 @default.
- W2892743324 hasConcept C147483822 @default.
- W2892743324 hasConcept C154317977 @default.
- W2892743324 hasConcept C167672396 @default.
- W2892743324 hasConcept C183193105 @default.
- W2892743324 hasConcept C185592680 @default.
- W2892743324 hasConcept C202751555 @default.
- W2892743324 hasConcept C203014093 @default.
- W2892743324 hasConcept C2776062744 @default.
- W2892743324 hasConcept C2776090121 @default.
- W2892743324 hasConcept C2778690821 @default.
- W2892743324 hasConcept C2780380082 @default.
- W2892743324 hasConcept C502942594 @default.
- W2892743324 hasConcept C55493867 @default.
- W2892743324 hasConcept C79484868 @default.
- W2892743324 hasConcept C86803240 @default.
- W2892743324 hasConcept C8891405 @default.
- W2892743324 hasConcept C95444343 @default.
- W2892743324 hasConceptScore W2892743324C129374314 @default.
- W2892743324 hasConceptScore W2892743324C147483822 @default.
- W2892743324 hasConceptScore W2892743324C154317977 @default.