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- W2892750589 abstract "The study aims at developing composite films of polyvinyl alcohol (PVA), chitosan (Cs) and Hydroxypropyl-methylcellulose(HPMC) using the solvent casting method. The films are developed with enhanced mechanical stability tohelp in reducing inflammation and providing the initial dressing to aid in wound healing. Films of different polymerratios were developed and optimized for further characterization studies, the optimal blends were then selected for drugdiffusion studies with curcumin. Films of HPMC:chitosan:PVA ratios of 1:1:1 and 1:1:2 have showed improved tensilestrength (56.77 MPa and 113.76 MPa respectively), showed more sustained swelling for 25 minutes in comparison toother samples. FTIR analysis and SEM analysis indicated interaction among the polymers while its surface morphologybeing continuous and uniform. Film HPMC:chitosan:PVA ratio of 1:1:1 (HCP1) exhibited substantially efficient releaseof 16.38±0.126% over 3 hours and found best fit in zero order following non Fickian diffusion. The film characteristicsand diffusion studies indicated that the drug-loaded film could hold good for its application in wound healing." @default.
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- W2892750589 date "2017-01-01" @default.
- W2892750589 modified "2023-09-23" @default.
- W2892750589 title "Development of Polyvinlyl Alcohol-Chitosan-Hydroxypropylmethylcellulose-based Composite Films for Controlled Drug Delivery" @default.
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