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- W2892757564 endingPage "2862" @default.
- W2892757564 startingPage "2848" @default.
- W2892757564 abstract "In yeast, protein kinase A (PKA) adjusts transcriptional profiles, metabolic rates, and cell growth in accord with carbon source availability. PKA affects gene expression mostly via the transcription factors Msn2 and Msn4, two key regulators of the environmental stress response. Here we analyze the role of the PKA-Msn2 signaling module using an Msn2 allele that harbors serine-to-alanine substitutions at six functionally important PKA motifs (Msn2A6) . Expression of Msn2A6 mimics low PKA activity, entails a transcription profile similar to that of respiring cells, and prevents formation of colonies on glucose-containing medium. Furthermore, Msn2A6 leads to high oxygen consumption and hence high respiratory activity. Substantially increased intracellular concentrations of several carbon metabolites, such as trehalose, point to a metabolic adjustment similar to diauxic shift. This partial metabolic switch is the likely cause for the slow-growth phenotype in the presence of glucose. Consistently, Msn2A6 expression does not interfere with growth on ethanol and tolerated is to a limited degree in deletion mutant strains with a gene expression signature corresponding to nonfermentative growth. We propose that the lethality observed in mutants with hampered PKA activity resides in metabolic reprogramming that is initiated by Msn2 hyperactivity." @default.
- W2892757564 created "2018-10-05" @default.
- W2892757564 creator A5003247532 @default.
- W2892757564 creator A5023933418 @default.
- W2892757564 creator A5029191933 @default.
- W2892757564 creator A5036923775 @default.
- W2892757564 creator A5051613634 @default.
- W2892757564 creator A5066261698 @default.
- W2892757564 creator A5076779628 @default.
- W2892757564 creator A5041119005 @default.
- W2892757564 date "2018-11-15" @default.
- W2892757564 modified "2023-10-17" @default.
- W2892757564 title "A constitutive active allele of the transcription factor Msn2 mimicking low PKA activity dictates metabolic remodeling in yeast" @default.
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