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• W2892758095 abstract "APAP (N-acetyl-p-aminophenol) is a widely used over-the-counter analgesic and anti–pyretic drug. APAP overdose can seriously damage several organs. Acrocarpus fraxinifolius Wight and Arn leaves (AFL) family Fabaceae is a medicinal tree species native to Africa and Asia. Traditionally, AFL is used in the prevention/treatment of liver and kidney damages. This study investigates the possible protective effects of AFL n-hexane extract (nHEAFL) against the APAP–induced organ toxicity in adult male Wistar albino rats. Rats were randomly divided into four groups. Group, I was the healthy control group that received placebo, group II (nHEAFL 500): rats received nHEAFL (500 mg/kg, p.o), group III (APAP+vehicle): rats received APAP (750 mg/kg, p.o) for 7 days. Group IV (nHEAFL 500+ APAP): rats pre-treated with nHEAFL (500 mg/kg, p.o) before inducing the organs damage in the last 7 days by APAP. Twenty-four hrs after last administration of APAP, the rats were sacrificed. APAP–induced a significant body weight loss, with the rise in serum liver markers (ASAT & ALAT), urea, uric acid, creatinine and renal/splenic/cardiac MDA, as well as with a reduction of cellular GSH, GR, GPx, SOD, and CAT activities. nHEAF showed a remarkable organs protective effect against APAP as evidenced by reduction of serum cellular toxicity and cellular lipid peroxidation, as well as enhanced cellular anti–oxidant defense system in renal/splenic/cardiac tissues. These findings suggest a potential protective role of AFL against APAP–induced organ toxicity in rats." @default.
• W2892758095 created "2018-10-05" @default.
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• W2892758095 date "2018-10-01" @default.
• W2892758095 modified "2023-09-28" @default.
• W2892758095 title "APAP–induced organ toxicity in rats: The prophylactic role of Acrocarpus fraxinifolius" @default.
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• W2892758095 hasPublicationYear "2018" @default.
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