FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892760462> ?p ?o ?g. }

• W2892760462 endingPage "2530" @default.
• W2892760462 startingPage "2520" @default.
• W2892760462 abstract "The present study evaluated the possible antiallodynic effect induced by [6]-gingerol in rats with L5–L6 spinal nerve ligation (SNL). Moreover, we determined the possible mechanism underlying the antiallodynic effect induced by [6]-gingerol in neuropathic rats. The animals underwent L5–L6 SNL for the purpose of developing tactile allodynia. Tactile allodynia was measured with von Frey filaments. Intrathecal administration of [6]-gingerol reversed SNL-induced tactile allodynia. The [6]-gingerol-induced antiallodynic effect was prevented by the intrathecal administration of methiothepin (30 μg per rat; nonselective 5-hydroxytryptamine [5-HT] antagonist), WAY-100635 (6 μg per rat; selective 5-HT1A receptor antagonist), SB-224289 (5 μg per rat; selective 5-HT1B receptor antagonist), BRL-15572 (4 μg per rat; selective 5-HT1D receptor antagonist), and SB-659551 (6 μg per rat; selective 5-HT5A receptor antagonist), but naloxone (50 μg per rat; nonselective opioid receptor antagonist) did not prevent the [6]-gingerol-induced antiallodynic effect. Moreover, intrathecal administration of Nω-nitro-l-arginine methyl ester (100 μg per rat; nonselective nitric oxide [NO] synthase inhibitor), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (10 μg per rat; inhibitor of guanylate cyclase), and glibenclamide (50 μg per rat; channel blocker of adenosine triphosphate [ATP]-sensitive K+ channels) prevented the [6]-gingerol-induced antiallodynic effect. These data suggest that the antiallodynic effect induced by [6]-gingerol is mediated by the serotoninergic system involving the activation of 5-HT1A/1B/1D/5A receptors, as well as the NO–cyclic guanosine monophosphate–ATP-sensitive K+ channel pathway but not by the opioidergic system." @default.
• W2892760462 created "2018-10-05" @default.
• W2892760462 creator A5021749197 @default.
• W2892760462 creator A5025281014 @default.
• W2892760462 creator A5042636494 @default.
• W2892760462 creator A5065434433 @default.
• W2892760462 creator A5060950931 @default.
• W2892760462 date "2018-09-24" @default.
• W2892760462 modified "2023-10-15" @default.
• W2892760462 title "Antiallodynic effect induced by [6]-gingerol in neuropathic rats is mediated by activation of the serotoninergic system and the nitric oxide-cyclic guanosine monophosphate-adenosine triphosphate-sensitive K⁺ channel pathway" @default.
• W2892760462 cites W1496398523 @default.
• W2892760462 cites W1511068333 @default.
• W2892760462 cites W1965866432 @default.
• W2892760462 cites W1977665632 @default.
• W2892760462 cites W1981480712 @default.
• W2892760462 cites W1982523260 @default.
• W2892760462 cites W1984956427 @default.
• W2892760462 cites W1987139868 @default.
• W2892760462 cites W1987304772 @default.
• W2892760462 cites W1990126285 @default.
• W2892760462 cites W1995014753 @default.
• W2892760462 cites W1999908521 @default.
• W2892760462 cites W2000663551 @default.
• W2892760462 cites W2018241451 @default.
• W2892760462 cites W2038238762 @default.
• W2892760462 cites W2038316076 @default.
• W2892760462 cites W2042741271 @default.
• W2892760462 cites W2043323520 @default.
• W2892760462 cites W2045886062 @default.
• W2892760462 cites W2056564326 @default.
• W2892760462 cites W2062088904 @default.
• W2892760462 cites W2081241211 @default.
• W2892760462 cites W2086305651 @default.
• W2892760462 cites W2087454739 @default.
• W2892760462 cites W2103351070 @default.
• W2892760462 cites W2137037902 @default.
• W2892760462 cites W2137816677 @default.
• W2892760462 cites W2138166241 @default.
• W2892760462 cites W2140302775 @default.
• W2892760462 cites W2140888147 @default.
• W2892760462 cites W2154369124 @default.
• W2892760462 cites W2169767676 @default.
• W2892760462 cites W2172201406 @default.
• W2892760462 cites W2544258276 @default.
• W2892760462 cites W2544885860 @default.
• W2892760462 cites W788357546 @default.
• W2892760462 cites W89713122 @default.
• W2892760462 doi "https://doi.org/10.1002/ptr.6191" @default.
• W2892760462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30251306" @default.
• W2892760462 hasPublicationYear "2018" @default.
• W2892760462 type Work @default.
• W2892760462 sameAs 2892760462 @default.
• W2892760462 citedByCount "16" @default.
• W2892760462 countsByYear W28927604622020 @default.
• W2892760462 countsByYear W28927604622021 @default.
• W2892760462 countsByYear W28927604622022 @default.
• W2892760462 countsByYear W28927604622023 @default.
• W2892760462 crossrefType "journal-article" @default.
• W2892760462 hasAuthorship W2892760462A5021749197 @default.
• W2892760462 hasAuthorship W2892760462A5025281014 @default.
• W2892760462 hasAuthorship W2892760462A5042636494 @default.
• W2892760462 hasAuthorship W2892760462A5060950931 @default.
• W2892760462 hasAuthorship W2892760462A5065434433 @default.
• W2892760462 hasConcept C134018914 @default.
• W2892760462 hasConcept C170493617 @default.
• W2892760462 hasConcept C178790620 @default.
• W2892760462 hasConcept C185592680 @default.
• W2892760462 hasConcept C2776885963 @default.
• W2892760462 hasConcept C2777107010 @default.
• W2892760462 hasConcept C2778122271 @default.
• W2892760462 hasConcept C2778750930 @default.
• W2892760462 hasConcept C2779004600 @default.
• W2892760462 hasConcept C2779768347 @default.
• W2892760462 hasConcept C2780994212 @default.
• W2892760462 hasConcept C519581460 @default.
• W2892760462 hasConcept C55493867 @default.
• W2892760462 hasConcept C555293320 @default.
• W2892760462 hasConcept C71924100 @default.
• W2892760462 hasConcept C98274493 @default.
• W2892760462 hasConceptScore W2892760462C134018914 @default.
• W2892760462 hasConceptScore W2892760462C170493617 @default.
• W2892760462 hasConceptScore W2892760462C178790620 @default.
• W2892760462 hasConceptScore W2892760462C185592680 @default.
• W2892760462 hasConceptScore W2892760462C2776885963 @default.
• W2892760462 hasConceptScore W2892760462C2777107010 @default.
• W2892760462 hasConceptScore W2892760462C2778122271 @default.
• W2892760462 hasConceptScore W2892760462C2778750930 @default.
• W2892760462 hasConceptScore W2892760462C2779004600 @default.
• W2892760462 hasConceptScore W2892760462C2779768347 @default.
• W2892760462 hasConceptScore W2892760462C2780994212 @default.
• W2892760462 hasConceptScore W2892760462C519581460 @default.
• W2892760462 hasConceptScore W2892760462C55493867 @default.
• W2892760462 hasConceptScore W2892760462C555293320 @default.
• W2892760462 hasConceptScore W2892760462C71924100 @default.
• W2892760462 hasConceptScore W2892760462C98274493 @default.
• W2892760462 hasFunder F4320322419 @default.
• W2892760462 hasIssue "12" @default.
• W2892760462 hasLocation W28927604621 @default.

• next