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• W2892762504 abstract "Gut microbes are capable of transforming choline into trimethylamine (TMA), and elevated serum trimethylamine-N-oxide (TMAO) levels are associated with cardiovascular diseases. Therapeutic approaches have focused on inhibiting microbial TMA formation. However, little is known about the degradation of TMA by gut bacteria. Here, we anaerobically cultivated and analyzed communities cultured with or without TMA. Enterococcus was significantly more abundant in communities cultured with TMA. Based on this observation, six Enterococcus strains were isolated from healthy human faecal samples, of which 3 Enterococcus faecalis isolates (E. faecalis Ef1, E. faecalis Ef2 and E. faecalis Ef3) could enable TMA degradation anaerobically. We further tested whether increased plasma TMAO levels in rats induced by a TMA-laden diet were attenuated by the administration of TMA-degrading E. faecalis. The results showed that these strains attenuated TMAO levels (mean 405.741 ng mL−1 for the experimental group vs mean 513.96 ng mL−1 for the control group, p < 0.05) after 14 days’ administration. To the best of our knowledge, our report is the first to demonstrate the TMA-degrading ability of human gut bacteria in vitro and in vivo. These results provide new insights into the prevention of TMAO-induced cardiovascular disease and suggest novel therapeutic approaches." @default.
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• W2892762504 date "2018-11-01" @default.
• W2892762504 modified "2023-10-18" @default.
• W2892762504 title "Degradation of trimethylamine in vitro and in vivo by Enterococcus faecalis isolated from healthy human gut" @default.
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• W2892762504 doi "https://doi.org/10.1016/j.ibiod.2018.09.005" @default.
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