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- W289276384 abstract "Publisher Summary To understand something of the contribution of germline and somatic events in the generation of a defined immune response, this chapter focuses on the antibodies produced by A/J mice in response to immunization with the hapten p-azophenylarsonate. The germline elements that give rise to this response have been isolated and structurally characterized. The contribution of junctional diversity, N-segment diversity, and somatic mutation are analyzed in the expressed antibodies. Additionally, the major idiotopes of these molecules have been correlated with the classically defined heterologous idiotype. The regulation of the response has been studied by idiotypic manipulation and the structure of molecules so induced has been characterized. The results of these studies, along with information derived from other model systems, provide important insights into the strategies employed by vertebrates for information storage and retrieval. The strain-specific system is the predominant response of A/J mice to immunization with the hapten p-azophenylarsonate coupled to keyhole limpet hemocyanin (Ars-KLH). Because Ars-KLH is an artificial immunogen, it can be viewed as a random probe into the variable region repertoire. As such, it has provided the means with which to study specific mechanisms that contribute to the acquisition of both germline and expressed diversity in both V and V genes." @default.
- W289276384 created "2016-06-24" @default.
- W289276384 creator A5008691036 @default.
- W289276384 creator A5027867915 @default.
- W289276384 creator A5035430209 @default.
- W289276384 creator A5057887755 @default.
- W289276384 creator A5074507227 @default.
- W289276384 date "1988-01-01" @default.
- W289276384 modified "2023-09-23" @default.
- W289276384 title "The Molecular Genetics of the Arsonate Idiotypic System of A/J Mice" @default.
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