FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892765143> ?p ?o ?g. }

• W2892765143 abstract "Metastasis is responsible for a significant number of breast cancer-related deaths. Hypoxia, a primary driving force of cancer metastasis, induces the expression of BHLHE40, a transcription regulator. This study aimed to elucidate the function of BHLHE40 in the metastatic process of breast cancer cells.To define the role of BHLHE40 in breast cancer, BHLHE40 expression was knocked down by a lentiviral construct expressing a short hairpin RNA against BHLHE40 or knocked out by the CRISPR/Cas9 editing system. Orthotopic xenograft and experimental metastasis (tail vein injection) mouse models were used to analyze the role of BHLHE40 in lung metastasis of breast cancer. Global gene expression analysis and public database mining were performed to identify signaling pathways regulated by BHLHE40 in breast cancer. The action mechanism of BHLHE40 was examined by chromatin immunoprecipitation (ChIP), co-immunoprecipitation (CoIP), exosome analysis, and cell-based assays for metastatic potential.BHLHE40 knockdown significantly reduced primary tumor growth and lung metastasis in orthotopic xenograft and experimental metastasis models of breast cancer. Gene expression analysis implicated a role of BHLHE40 in transcriptional activation of heparin-binding epidermal growth factor (HBEGF). ChIP and CoIP assays revealed that BHLHE40 induces HBEGF transcription by blocking DNA binding of histone deacetylases (HDAC)1 and HDAC2. Cell-based assays showed that HBEGF is secreted through exosomes and acts to promote cell survival and migration. Public databases provided evidence linking high expression of BHLHE40 and HBEGF to poor prognosis of triple-negative breast cancer.This study reveals a novel role of BHLHE40 in promoting tumor cell survival and migration by regulating HBEGF secretion." @default.
• W2892765143 created "2018-10-05" @default.
• W2892765143 creator A5016109284 @default.
• W2892765143 creator A5041211299 @default.
• W2892765143 creator A5050941184 @default.
• W2892765143 creator A5056364613 @default.
• W2892765143 creator A5066570735 @default.
• W2892765143 creator A5086482886 @default.
• W2892765143 creator A5090420512 @default.
• W2892765143 date "2018-10-01" @default.
• W2892765143 modified "2023-10-12" @default.
• W2892765143 title "BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion" @default.
• W2892765143 cites W1682077723 @default.
• W2892765143 cites W1784032068 @default.
• W2892765143 cites W1832220924 @default.
• W2892765143 cites W1908864745 @default.
• W2892765143 cites W1983189984 @default.
• W2892765143 cites W1996281588 @default.
• W2892765143 cites W1999390452 @default.
• W2892765143 cites W2014822965 @default.
• W2892765143 cites W2016057875 @default.
• W2892765143 cites W2023279237 @default.
• W2892765143 cites W2029245949 @default.
• W2892765143 cites W2039495870 @default.
• W2892765143 cites W2041514890 @default.
• W2892765143 cites W2044702943 @default.
• W2892765143 cites W2055175726 @default.
• W2892765143 cites W2058729725 @default.
• W2892765143 cites W2062843221 @default.
• W2892765143 cites W2069518226 @default.
• W2892765143 cites W2080831931 @default.
• W2892765143 cites W2081124475 @default.
• W2892765143 cites W2084770914 @default.
• W2892765143 cites W2085934079 @default.
• W2892765143 cites W2089517473 @default.
• W2892765143 cites W2096283457 @default.
• W2892765143 cites W2102374805 @default.
• W2892765143 cites W2106605842 @default.
• W2892765143 cites W2108057472 @default.
• W2892765143 cites W2111789872 @default.
• W2892765143 cites W2116972361 @default.
• W2892765143 cites W2133011337 @default.
• W2892765143 cites W2139745007 @default.
• W2892765143 cites W2140241614 @default.
• W2892765143 cites W2142819472 @default.
• W2892765143 cites W2147150467 @default.
• W2892765143 cites W2165734811 @default.
• W2892765143 cites W2167520439 @default.
• W2892765143 cites W2169663073 @default.
• W2892765143 cites W2170852633 @default.
• W2892765143 cites W2204695292 @default.
• W2892765143 cites W2210270878 @default.
• W2892765143 cites W2274725248 @default.
• W2892765143 cites W2279808202 @default.
• W2892765143 cites W2323751645 @default.
• W2892765143 cites W2383223917 @default.
• W2892765143 cites W2398473974 @default.
• W2892765143 cites W2485991133 @default.
• W2892765143 cites W2515199119 @default.
• W2892765143 cites W2560367415 @default.
• W2892765143 cites W2566408036 @default.
• W2892765143 cites W2781525129 @default.
• W2892765143 cites W2789637558 @default.
• W2892765143 cites W2791857381 @default.
• W2892765143 cites W4232995978 @default.
• W2892765143 cites W576850159 @default.
• W2892765143 doi "https://doi.org/10.1186/s13058-018-1046-3" @default.
• W2892765143 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6167787" @default.
• W2892765143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30285805" @default.
• W2892765143 hasPublicationYear "2018" @default.
• W2892765143 type Work @default.
• W2892765143 sameAs 2892765143 @default.
• W2892765143 citedByCount "36" @default.
• W2892765143 countsByYear W28927651432019 @default.
• W2892765143 countsByYear W28927651432020 @default.
• W2892765143 countsByYear W28927651432021 @default.
• W2892765143 countsByYear W28927651432022 @default.
• W2892765143 countsByYear W28927651432023 @default.
• W2892765143 crossrefType "journal-article" @default.
• W2892765143 hasAuthorship W2892765143A5016109284 @default.
• W2892765143 hasAuthorship W2892765143A5041211299 @default.
• W2892765143 hasAuthorship W2892765143A5050941184 @default.
• W2892765143 hasAuthorship W2892765143A5056364613 @default.
• W2892765143 hasAuthorship W2892765143A5066570735 @default.
• W2892765143 hasAuthorship W2892765143A5086482886 @default.
• W2892765143 hasAuthorship W2892765143A5090420512 @default.
• W2892765143 hasBestOaLocation W28927651431 @default.
• W2892765143 hasConcept C101762097 @default.
• W2892765143 hasConcept C104317684 @default.
• W2892765143 hasConcept C121608353 @default.
• W2892765143 hasConcept C126322002 @default.
• W2892765143 hasConcept C134320426 @default.
• W2892765143 hasConcept C150194340 @default.
• W2892765143 hasConcept C173396325 @default.
• W2892765143 hasConcept C2779013556 @default.
• W2892765143 hasConcept C2780140570 @default.
• W2892765143 hasConcept C502942594 @default.
• W2892765143 hasConcept C530470458 @default.
• W2892765143 hasConcept C54355233 @default.
• W2892765143 hasConcept C55493867 @default.

• next