FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892785222> ?p ?o ?g. }

• W2892785222 endingPage "1294" @default.
• W2892785222 startingPage "1286" @default.
• W2892785222 abstract "A wide variety of factors are required for the conversion of pre-tRNA molecules into the mature tRNAs that function in translation. To identify factors influencing tRNA biogenesis, we previously performed a screen for strains carrying mutations that induce lethality when combined with a sup61-T47:2C allele, encoding a mutant form of tRNACGASer. Analyzes of two complementation groups led to the identification of Tan1 as a protein involved in formation of the modified nucleoside N4-acetylcytidine (ac4C) in tRNA and Bud13 as a factor controlling the levels of ac4C by promoting TAN1 pre-mRNA splicing. Here, we describe the remaining complementation groups and show that they include strains with mutations in genes for known tRNA biogenesis factors that modify (DUS2, MOD5 and TRM1), transport (LOS1), or aminoacylate (SES1) tRNACGASer. Other strains carried mutations in genes for factors involved in rRNA/mRNA synthesis (RPA49, RRN3 and MOT1) or magnesium uptake (ALR1). We show that mutations in not only DUS2, LOS1 and SES1 but also in RPA49, RRN3 and MOT1 cause a reduction in the levels of the altered tRNACGASer. These results indicate that Rpa49, Rrn3 and Mot1 directly or indirectly influence tRNACGASer biogenesis." @default.
• W2892785222 created "2018-10-05" @default.
• W2892785222 creator A5001568044 @default.
• W2892785222 creator A5027356879 @default.
• W2892785222 creator A5045194296 @default.
• W2892785222 creator A5078192964 @default.
• W2892785222 date "2018-10-03" @default.
• W2892785222 modified "2023-09-23" @default.
• W2892785222 title "Identification of factors that promote biogenesis of tRNA_CGA^Ser" @default.
• W2892785222 cites W1564223124 @default.
• W2892785222 cites W1574958149 @default.
• W2892785222 cites W1681659541 @default.
• W2892785222 cites W1838863859 @default.
• W2892785222 cites W1917073860 @default.
• W2892785222 cites W1966072209 @default.
• W2892785222 cites W1968321573 @default.
• W2892785222 cites W1969737313 @default.
• W2892785222 cites W1971706653 @default.
• W2892785222 cites W1973114023 @default.
• W2892785222 cites W1976318017 @default.
• W2892785222 cites W1977876594 @default.
• W2892785222 cites W1977889868 @default.
• W2892785222 cites W1977971644 @default.
• W2892785222 cites W1985372011 @default.
• W2892785222 cites W1988391179 @default.
• W2892785222 cites W1992416271 @default.
• W2892785222 cites W2000293147 @default.
• W2892785222 cites W2004749785 @default.
• W2892785222 cites W2007783008 @default.
• W2892785222 cites W2012920273 @default.
• W2892785222 cites W2023804040 @default.
• W2892785222 cites W2027534342 @default.
• W2892785222 cites W2028260685 @default.
• W2892785222 cites W2029083573 @default.
• W2892785222 cites W2053161221 @default.
• W2892785222 cites W2055083006 @default.
• W2892785222 cites W2055977185 @default.
• W2892785222 cites W2059553154 @default.
• W2892785222 cites W2071332261 @default.
• W2892785222 cites W2071475568 @default.
• W2892785222 cites W2089825698 @default.
• W2892785222 cites W2091021589 @default.
• W2892785222 cites W2091512138 @default.
• W2892785222 cites W2092834021 @default.
• W2892785222 cites W2094729320 @default.
• W2892785222 cites W2097843864 @default.
• W2892785222 cites W2098758937 @default.
• W2892785222 cites W2098936960 @default.
• W2892785222 cites W2102787779 @default.
• W2892785222 cites W2105661146 @default.
• W2892785222 cites W2107622595 @default.
• W2892785222 cites W2112201668 @default.
• W2892785222 cites W2112765717 @default.
• W2892785222 cites W2119635233 @default.
• W2892785222 cites W2131037303 @default.
• W2892785222 cites W2133168873 @default.
• W2892785222 cites W2139558883 @default.
• W2892785222 cites W2140673402 @default.
• W2892785222 cites W2143121662 @default.
• W2892785222 cites W2145619687 @default.
• W2892785222 cites W2146503498 @default.
• W2892785222 cites W2148399893 @default.
• W2892785222 cites W2149150109 @default.
• W2892785222 cites W2152558835 @default.
• W2892785222 cites W2159685047 @default.
• W2892785222 cites W2169333620 @default.
• W2892785222 cites W2171901504 @default.
• W2892785222 cites W223631699 @default.
• W2892785222 cites W2481183161 @default.
• W2892785222 cites W2549872569 @default.
• W2892785222 cites W2563623339 @default.
• W2892785222 cites W2588029497 @default.
• W2892785222 cites W2768762471 @default.
• W2892785222 cites W4240242732 @default.
• W2892785222 doi "https://doi.org/10.1080/15476286.2018.1526539" @default.
• W2892785222 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6284589" @default.
• W2892785222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30269676" @default.
• W2892785222 hasPublicationYear "2018" @default.
• W2892785222 type Work @default.
• W2892785222 sameAs 2892785222 @default.
• W2892785222 citedByCount "6" @default.
• W2892785222 countsByYear W28927852222019 @default.
• W2892785222 countsByYear W28927852222020 @default.
• W2892785222 countsByYear W28927852222021 @default.
• W2892785222 countsByYear W28927852222022 @default.
• W2892785222 crossrefType "journal-article" @default.
• W2892785222 hasAuthorship W2892785222A5001568044 @default.
• W2892785222 hasAuthorship W2892785222A5027356879 @default.
• W2892785222 hasAuthorship W2892785222A5045194296 @default.
• W2892785222 hasAuthorship W2892785222A5078192964 @default.
• W2892785222 hasBestOaLocation W28927852221 @default.
• W2892785222 hasConcept C104317684 @default.
• W2892785222 hasConcept C105580179 @default.
• W2892785222 hasConcept C131934819 @default.
• W2892785222 hasConcept C143065580 @default.
• W2892785222 hasConcept C149364088 @default.
• W2892785222 hasConcept C153957851 @default.
• W2892785222 hasConcept C188082640 @default.

• next