FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892794093> ?p ?o ?g. }

• W2892794093 abstract "Clear cell renal cell carcinoma (ccRCC) is the most frequent type of renal cell carcinoma (RCC). The present study aimed to examine prognostic markers and construct a prognostic prediction system for ccRCC. The mRNA sequencing data of ccRCC was downloaded from The Cancer Genome Atlas (TCGA) database, and the GSE40435 dataset was obtained from the Gene Expression Omnibus database. Using the Limma package, the differentially expressed genes (DEGs) in the TCGA dataset and GSE40435 dataset were obtained, respectively, and the overlapped DEGs were selected. Subsequently, Cox regression analysis was applied for screening prognosis‑associated genes. Following visualization of the co‑expression network using Cytoscape software, the network modules were examined using the GraphWeb tool. Functional annotation for genes in the network was performed using the clusterProfiler package. Finally, a prognostic prediction system was constructed through Bayes discriminant analysis and confirmed with the GSE29609 validation dataset. The results revealed a total of 263 overlapped DEGs and 161 prognosis‑associated genes. Following construction of the co‑expression network, 16 functional terms and three pathways were obtained for genes in the network. In addition, red, yellow (involving chemokine ligand 10 (CXCL10), CD27 molecule (CD27) and runt‑related transcription factor 3 (RUNX3)], green (involving angiopoietin‑like 4 (ANGPTL4), stanniocalcin 2 (STC2), and sperm associated antigen 4 (SPAG4)], and cyan modules were extracted from the co‑expression network. Additionally, the prognostic prediction system involving 44 signature genes, including ANGPTL4, STC2, CXCL10, SPAG4, CD27, matrix metalloproteinase (MMP9) and RUNX3, was identified and confirmed. In conclusion, the 44‑gene prognostic prediction system involving ANGPTL4, STC2, CXCL10, SPAG4, CD27, MMP9 and RUNX3 may be utilized for predicting the prognosis of patients with ccRCC." @default.
• W2892794093 created "2018-10-05" @default.
• W2892794093 creator A5000970532 @default.
• W2892794093 creator A5011241874 @default.
• W2892794093 creator A5060470951 @default.
• W2892794093 date "2018-09-26" @default.
• W2892794093 modified "2023-09-25" @default.
• W2892794093 title "A 44-gene set constructed for predicting the�prognosis of clear cell renal cell carcinoma" @default.
• W2892794093 cites W1270834676 @default.
• W2892794093 cites W1527543926 @default.
• W2892794093 cites W1695734089 @default.
• W2892794093 cites W1902994240 @default.
• W2892794093 cites W1927769715 @default.
• W2892794093 cites W1968980848 @default.
• W2892794093 cites W1987977871 @default.
• W2892794093 cites W1991649432 @default.
• W2892794093 cites W1992854482 @default.
• W2892794093 cites W1995668305 @default.
• W2892794093 cites W2000599093 @default.
• W2892794093 cites W2007495351 @default.
• W2892794093 cites W2008134578 @default.
• W2892794093 cites W2035618305 @default.
• W2892794093 cites W2039090342 @default.
• W2892794093 cites W2041550107 @default.
• W2892794093 cites W2058989190 @default.
• W2892794093 cites W2063593969 @default.
• W2892794093 cites W2066447707 @default.
• W2892794093 cites W2066750311 @default.
• W2892794093 cites W2066878287 @default.
• W2892794093 cites W2067491629 @default.
• W2892794093 cites W2080483894 @default.
• W2892794093 cites W2082331198 @default.
• W2892794093 cites W2089887319 @default.
• W2892794093 cites W2097771645 @default.
• W2892794093 cites W2097842049 @default.
• W2892794093 cites W2119231799 @default.
• W2892794093 cites W2125367002 @default.
• W2892794093 cites W2135236987 @default.
• W2892794093 cites W2140131237 @default.
• W2892794093 cites W2145429526 @default.
• W2892794093 cites W2146994504 @default.
• W2892794093 cites W2147264650 @default.
• W2892794093 cites W2151365262 @default.
• W2892794093 cites W2164317031 @default.
• W2892794093 cites W2167122624 @default.
• W2892794093 cites W2185985010 @default.
• W2892794093 cites W2189483818 @default.
• W2892794093 cites W2288326375 @default.
• W2892794093 cites W2399288549 @default.
• W2892794093 cites W2551357583 @default.
• W2892794093 cites W2556877281 @default.
• W2892794093 cites W2573872569 @default.
• W2892794093 cites W2761276964 @default.
• W2892794093 cites W2789615218 @default.
• W2892794093 cites W2911611736 @default.
• W2892794093 doi "https://doi.org/10.3892/ijmm.2018.3899" @default.
• W2892794093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6202093" @default.
• W2892794093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30272265" @default.
• W2892794093 hasPublicationYear "2018" @default.
• W2892794093 type Work @default.
• W2892794093 sameAs 2892794093 @default.
• W2892794093 citedByCount "10" @default.
• W2892794093 countsByYear W28927940932019 @default.
• W2892794093 countsByYear W28927940932020 @default.
• W2892794093 countsByYear W28927940932021 @default.
• W2892794093 countsByYear W28927940932022 @default.
• W2892794093 crossrefType "journal-article" @default.
• W2892794093 hasAuthorship W2892794093A5000970532 @default.
• W2892794093 hasAuthorship W2892794093A5011241874 @default.
• W2892794093 hasAuthorship W2892794093A5060470951 @default.
• W2892794093 hasBestOaLocation W28927940931 @default.
• W2892794093 hasConcept C104317684 @default.
• W2892794093 hasConcept C126322002 @default.
• W2892794093 hasConcept C143998085 @default.
• W2892794093 hasConcept C150194340 @default.
• W2892794093 hasConcept C152724338 @default.
• W2892794093 hasConcept C162317418 @default.
• W2892794093 hasConcept C2777472916 @default.
• W2892794093 hasConcept C2781278892 @default.
• W2892794093 hasConcept C50382708 @default.
• W2892794093 hasConcept C54355233 @default.
• W2892794093 hasConcept C67339327 @default.
• W2892794093 hasConcept C70721500 @default.
• W2892794093 hasConcept C71924100 @default.
• W2892794093 hasConcept C86803240 @default.
• W2892794093 hasConceptScore W2892794093C104317684 @default.
• W2892794093 hasConceptScore W2892794093C126322002 @default.
• W2892794093 hasConceptScore W2892794093C143998085 @default.
• W2892794093 hasConceptScore W2892794093C150194340 @default.
• W2892794093 hasConceptScore W2892794093C152724338 @default.
• W2892794093 hasConceptScore W2892794093C162317418 @default.
• W2892794093 hasConceptScore W2892794093C2777472916 @default.
• W2892794093 hasConceptScore W2892794093C2781278892 @default.
• W2892794093 hasConceptScore W2892794093C50382708 @default.
• W2892794093 hasConceptScore W2892794093C54355233 @default.
• W2892794093 hasConceptScore W2892794093C67339327 @default.
• W2892794093 hasConceptScore W2892794093C70721500 @default.
• W2892794093 hasConceptScore W2892794093C71924100 @default.
• W2892794093 hasConceptScore W2892794093C86803240 @default.
• W2892794093 hasLocation W28927940931 @default.

• next