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• W2892801584 abstract "Progress in determining the precise organization and function of the claustrum (CLA) has been hindered by the difficulty in reliably targeting these neurons. To overcome this, we used a projection-based targeting strategy to selectively label CLA principal neurons. Combined with adeno-associated virus (AAV) and monosynaptic rabies tracing techniques, we systematically examined the pre-synaptic input and axonal output of this structure. We found that CLA neurons projecting to retrosplenial cortex (RSP) collateralize extensively to innervate a variety of higher-order cortical regions. No subcortical labeling was found, with the exception of sparse terminals in the basolateral amygdala (BLA). This pattern of output was similar to cingulate- and visual cortex-projecting CLA neurons, suggesting a common targeting scheme among these projection-defined populations. Rabies virus tracing directly demonstrated widespread synaptic inputs to RSP-projecting CLA neurons from both cortical and subcortical areas. The strongest inputs arose from classically defined limbic regions, including medial prefrontal cortex, anterior cingulate, BLA, ventral hippocampus, and neuromodulatory systems such as the dorsal raphe and cholinergic basal forebrain. These results suggest that the CLA may integrate information related to the emotional salience of stimuli and may globally modulate cortical state by broadcasting its output uniformly across a variety of higher cognitive centers." @default.
• W2892801584 created "2018-10-05" @default.
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• W2892801584 date "2018-09-25" @default.
• W2892801584 modified "2023-10-17" @default.
• W2892801584 title "Input-output organization of the mouse claustrum" @default.
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• W2892801584 doi "https://doi.org/10.1002/cne.24502" @default.
• W2892801584 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6196111" @default.
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• W2892801584 hasPublicationYear "2018" @default.
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