FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892812964> ?p ?o ?g. }

• W2892812964 abstract "Abstract Exosomes have shown increasing potential as delivery vesicles for therapy, but challenges like cost/yield, drug payload, and targeting specificity still exist. Plant derived exosome-like nanoparticles have been reported as a promising substitution and exhibit biocompatibility through oral, intranasal administration; however, systemic delivery of siRNA by exosome-like nanoparticles directly isolated from plants has not been reported. Recently, we reported the control of RNA orientation to decorate human derived exosome with cell targeting ligands for specific delivery of siRNA to tumors. Here, we expand to the application of arrowtail RNA nanoparticles for displaying ligands on ginger derived exosome-like nanovesicles (GDENs) for siRNA delivery and tumor inhibition through IV administration. Cushion ultracentrifugation coupled with equilibrium density gradient ultracentrifugation were used for purifying GDENs that displayed size, density, and morphology similar to human derived exosomes. Folic acid (FA), as a ligand, was displayed on the surface of GDENs for targeted delivery of survivin siRNA to KB cancer models. In vitro gene knockdown efficacy by FA-3WJ/GDENs/siRNA complex was comparable to transfection. We observed inhibition of tumor growth on a xenograft model by intravenous administration, which reveals the potential of GDENs as an economic delivery system for siRNA." @default.
• W2892812964 created "2018-10-05" @default.
• W2892812964 creator A5018181233 @default.
• W2892812964 creator A5049301997 @default.
• W2892812964 creator A5056167916 @default.
• W2892812964 creator A5060587776 @default.
• W2892812964 creator A5069765017 @default.
• W2892812964 creator A5079723871 @default.
• W2892812964 date "2018-10-02" @default.
• W2892812964 modified "2023-10-14" @default.
• W2892812964 title "Arrowtail RNA for Ligand Display on Ginger Exosome-like Nanovesicles to Systemic Deliver siRNA for Cancer Suppression" @default.
• W2892812964 cites W1877686344 @default.
• W2892812964 cites W1918903475 @default.
• W2892812964 cites W1964790454 @default.
• W2892812964 cites W1966384509 @default.
• W2892812964 cites W1977144298 @default.
• W2892812964 cites W1985619179 @default.
• W2892812964 cites W1985944218 @default.
• W2892812964 cites W1993337563 @default.
• W2892812964 cites W1998774632 @default.
• W2892812964 cites W2040250419 @default.
• W2892812964 cites W2055313665 @default.
• W2892812964 cites W2059002977 @default.
• W2892812964 cites W2066234893 @default.
• W2892812964 cites W2066788401 @default.
• W2892812964 cites W2070070981 @default.
• W2892812964 cites W2072912619 @default.
• W2892812964 cites W2080450988 @default.
• W2892812964 cites W2101053145 @default.
• W2892812964 cites W2105251923 @default.
• W2892812964 cites W2106347959 @default.
• W2892812964 cites W2110826783 @default.
• W2892812964 cites W2111440720 @default.
• W2892812964 cites W2122487966 @default.
• W2892812964 cites W2125536449 @default.
• W2892812964 cites W2131060408 @default.
• W2892812964 cites W2134173784 @default.
• W2892812964 cites W2158037611 @default.
• W2892812964 cites W2164530723 @default.
• W2892812964 cites W2171962490 @default.
• W2892812964 cites W2175705385 @default.
• W2892812964 cites W2178935826 @default.
• W2892812964 cites W2179283706 @default.
• W2892812964 cites W2183061082 @default.
• W2892812964 cites W2200617834 @default.
• W2892812964 cites W2210338352 @default.
• W2892812964 cites W2314704003 @default.
• W2892812964 cites W2340580991 @default.
• W2892812964 cites W2412922914 @default.
• W2892812964 cites W2415407195 @default.
• W2892812964 cites W2441633445 @default.
• W2892812964 cites W2462022051 @default.
• W2892812964 cites W2555205590 @default.
• W2892812964 cites W2563634884 @default.
• W2892812964 cites W2589694509 @default.
• W2892812964 cites W2592699639 @default.
• W2892812964 cites W2724456265 @default.
• W2892812964 cites W2761606107 @default.
• W2892812964 cites W2774123716 @default.
• W2892812964 cites W947799404 @default.
• W2892812964 doi "https://doi.org/10.1038/s41598-018-32953-7" @default.
• W2892812964 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6168523" @default.
• W2892812964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30279553" @default.
• W2892812964 hasPublicationYear "2018" @default.
• W2892812964 type Work @default.
• W2892812964 sameAs 2892812964 @default.
• W2892812964 citedByCount "96" @default.
• W2892812964 countsByYear W28928129642019 @default.
• W2892812964 countsByYear W28928129642020 @default.
• W2892812964 countsByYear W28928129642021 @default.
• W2892812964 countsByYear W28928129642022 @default.
• W2892812964 countsByYear W28928129642023 @default.
• W2892812964 crossrefType "journal-article" @default.
• W2892812964 hasAuthorship W2892812964A5018181233 @default.
• W2892812964 hasAuthorship W2892812964A5049301997 @default.
• W2892812964 hasAuthorship W2892812964A5056167916 @default.
• W2892812964 hasAuthorship W2892812964A5060587776 @default.
• W2892812964 hasAuthorship W2892812964A5069765017 @default.
• W2892812964 hasAuthorship W2892812964A5079723871 @default.
• W2892812964 hasBestOaLocation W28928129641 @default.
• W2892812964 hasConcept C104317684 @default.
• W2892812964 hasConcept C139770010 @default.
• W2892812964 hasConcept C145059251 @default.
• W2892812964 hasConcept C1491633281 @default.
• W2892812964 hasConcept C150903083 @default.
• W2892812964 hasConcept C173396325 @default.
• W2892812964 hasConcept C178790620 @default.
• W2892812964 hasConcept C185592680 @default.
• W2892812964 hasConcept C190283241 @default.
• W2892812964 hasConcept C202751555 @default.
• W2892812964 hasConcept C20518536 @default.
• W2892812964 hasConcept C207001950 @default.
• W2892812964 hasConcept C22615655 @default.
• W2892812964 hasConcept C25938499 @default.
• W2892812964 hasConcept C2779820397 @default.
• W2892812964 hasConcept C2781261824 @default.
• W2892812964 hasConcept C502942594 @default.
• W2892812964 hasConcept C54009773 @default.
• W2892812964 hasConcept C55493867 @default.
• W2892812964 hasConcept C67705224 @default.

• next