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• W2892852820 abstract "Abstract Purpose The intrinsically photosensitive retinal ganglion cells (ip RGC s) signal environmental light, control pupil size and entrain circadian rhythm. There is speculation that ip RGC s may be involved in the protective effects of light exposure in myopia. Here, the ip RGC ‐driven pupil response was evaluated in children and examined with light exposure and refractive error. Methods Children ages 5–15 years participated. Subjects wore an actigraph device prior to the lab visit for objective measures of light exposure and sleep. For pupillometry, the left eye was dilated and presented with stimuli, and the consensual pupil response was measured in the right eye. Pupil measurements were preceded by 5 min dark adaptation. In Experiment 1 ( n = 14), 1 s long wavelength light (‘red,’ 651 nm, 167 cd m −2 ) and 10 increasing intensities of 1 s short wavelength light (‘blue,’ 456 nm, 0.167–167 cd m −2 ) were presented with a 60 s interstimulus interval. A piecewise two‐segment regression was fit to the stimulus response function to determine the functional melanopsin threshold. Pupil responses were analysed with light exposure over the previous 24 h. For Experiment 2 ( n = 42), three 1 s red and three 1 s blue alternating stimuli were presented with a 60 s interstimulus interval. Following an additional 5‐min dark adaption, the experiment was repeated. Pupil metrics included peak constriction, the 6 s and 30 s post‐illumination response ( PIPR ), early and late area under the curve ( AUC ). Following pupil measurements, cycloplegic refractive error and axial length were measured. Results For Experiment 1, PIPR metrics demonstrated a graded response to increasing intensity blue stimuli, with a mean functional melanopsin threshold of 6.2 ± 4.5 cd m −2 (range: 0.84–16.7 cd m −2 ). The 6 s PIPR and early AUC were associated with 24‐h light exposure for high intensity stimuli (33.3 and 83.3 cd m −2 , p < 0.005 for both). For Experiment 2, there were no associations between pupil metrics and refractive error. The 6 s PIPR and early AUC to blue stimuli were significantly increased for Trial 2 compared to Trial 1. Conclusions The ip RGC ‐driven pupil responses in children were robust and similar to responses previously measured in an adult population. The 6 s PIPR and early AUC to high intensity blue stimuli were associated with previous light exposure. There were no associations between the ip RGC ‐driven pupil response and refractive status in this cohort." @default.
• W2892852820 created "2018-10-05" @default.
• W2892852820 creator A5072305886 @default.
• W2892852820 date "2018-09-01" @default.
• W2892852820 modified "2023-10-14" @default.
• W2892852820 title "The ip<scp>RGC</scp>‐driven pupil response with light exposure and refractive error in children" @default.
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• W2892852820 doi "https://doi.org/10.1111/opo.12583" @default.
• W2892852820 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6202139" @default.
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• W2892852820 hasPublicationYear "2018" @default.
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