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- W2892856247 abstract "987 Background: Mucins are the major secreted glycoprotein of gastrointestinal tract including the colon and the rectum. Aberrant expression of mucins has been known to play a role in colorectal carcinogenesis. Increased expression of MUC17, a recently identified membrane tethered mucin, was reported in pancreatic tumor tissues and in cancer cell lines of pancreas and colon. Nevertheless, the staining patterns of MUC17 and their clinical significance in colorectal adenocarcinomas (CRCs) have not been studied. Methods: One hundred and thirty six patients, who underwent surgical resection for CRC and had not received any pre- or -post surgery therapy, were selected for this study. Formalin-fixed paraffin embedded tissue specimens from these patients were evaluated for phenotypic expression of MUC17 using rabbit polyclonal antibody and horse-radish peroxidase detection method. The expression levels and patterns were correlated with different clinicopathologic features and patient outcomes. Results: In our study, MUC17 was localized to the cytoplasm, specifically in supra-nuclear position (punctate pattern), in all benign colonic epithelial tissues. In contrast, we observed two distinct patterns either punctate (60 of 136, 44%) or diffuse cytoplasmic (76 of 136, 56%) staining in tumor tissues. The cases in which the tumors exhibited diffuse cytoplasmic pattern were considered to be aberrant expressors of MUC17. The aberrant expression of MUC17 was significantly correlated with poor tumor differentiation (χ2, P=0.021) and with larger tumor size (χ2, P=0.011). Also, patients whose tumors demonstrated loss of punctate staining (diffuse cytoplasmic) patterns of MUC17 had a trend towards poor overall patient survival (logrank, P=0.072).Conclusion:These preliminary results suggest that the loss of punctate immunostaining pattern of MUC17 is associated with an aggressive behavior of colorectal adenocarcinomas and poor patient survival. This work is supported by funds from the National Institute of Health/National Cancer Institute (RO1-CA98932-01, 2U54-CA118948-03, U01CA111294, and the Early Detection Research Network, U24-CA086359)." @default.
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- W2892856247 date "2008-05-01" @default.
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- W2892856247 title "Aberrant phenotypic expression of MUC17 is associated with aggressive behavior of colorectal adenocarcinomas" @default.
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