Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892866758> ?p ?o ?g. }
- W2892866758 abstract "Abstract Background Altered cell metabolism is an established hallmark of cancer. Advancement in our understanding of dysregulated cellular metabolism has aided drastically in identifying metabolic vulnerabilities that can be exploited therapeutically. Indeed, this knowledge has led to the development of a multitude of agents targeting various aspects of tumor metabolism. Recent findings The intent of this review is to provide insight into small molecule inhibitors that target tumor metabolism and that are currently being explored in active clinical trials as either preventive, stand‐alone, or adjuvant therapies for various malignancies. For each inhibitor, we outline the mechanism (s) of action, preclinical/clinical findings, and limitations. Sections are divided into three aspects based on the primary target of the small molecule inhibitor (s): those that impact (1) cancer cells directly, (2) immune cells present in the tumor microenvironment, or (3) both cancer cells and immune cells. We highlight small molecule targeting of metabolic pathways including de novo fatty acid synthesis, NAD+ biosynthesis, 2‐hydroxyglutarate biosynthesis, polyamine metabolism, the kynurenine pathway, as well as glutamine and arginine metabolism. Conclusions Use of small molecule inhibitors aimed at exploiting tumor metabolic vulnerabilities continues to be an active area of research. Identifying metabolic dependencies specific to cancer cells and/or constituents of the tumor microenvironment is a viable area of therapeutic intervention that holds considerable clinical potential." @default.
- W2892866758 created "2018-10-05" @default.
- W2892866758 creator A5033841777 @default.
- W2892866758 creator A5040156444 @default.
- W2892866758 creator A5040696818 @default.
- W2892866758 creator A5072417435 @default.
- W2892866758 creator A5081331298 @default.
- W2892866758 date "2018-09-23" @default.
- W2892866758 modified "2023-10-16" @default.
- W2892866758 title "Targeting metabolic vulnerabilities of cancer: Small molecule inhibitors in clinic" @default.
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- W2892866758 doi "https://doi.org/10.1002/cnr2.1131" @default.