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- W2892867595 endingPage "11" @default.
- W2892867595 startingPage "1" @default.
- W2892867595 abstract "A mild chronic inflammatory state, like that observed in aged individuals, affects microglial function, inducing a dysfunctional phenotype that potentiates neuroinflammation and cytotoxicity instead of neuroprotection in response to additional challenges. Given that inflammatory activation of microglia promotes increased release of D-serine, we postulate that age-dependent inflammatory brain environment leads to microglia-mediated changes on the D-serine-regulated glutamatergic transmission. Furthermore, D-serine dysregulation, in addition to affecting synaptogenesis and synaptic plasticity, appears also to potentiate NMDAR-dependent excitotoxicity, promoting neurodegeneration and cognitive impairment. D-serine dysregulation promoted by microglia could have a role in age-related cognitive impairment and in the induction and progression of neurodegenerative processes like Alzheimer's disease." @default.
- W2892867595 created "2018-10-05" @default.
- W2892867595 creator A5044094653 @default.
- W2892867595 creator A5069439442 @default.
- W2892867595 creator A5087630334 @default.
- W2892867595 date "2018-09-27" @default.
- W2892867595 modified "2023-10-17" @default.
- W2892867595 title "Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS" @default.
- W2892867595 cites W1482841897 @default.
- W2892867595 cites W1488124756 @default.
- W2892867595 cites W1493890929 @default.
- W2892867595 cites W1499171768 @default.
- W2892867595 cites W1514130220 @default.
- W2892867595 cites W1570236416 @default.
- W2892867595 cites W1586876258 @default.
- W2892867595 cites W1608433819 @default.
- W2892867595 cites W1678806040 @default.
- W2892867595 cites W1764878327 @default.
- W2892867595 cites W1793612468 @default.
- W2892867595 cites W1817666133 @default.
- W2892867595 cites W1928993351 @default.
- W2892867595 cites W1966522871 @default.
- W2892867595 cites W1966556202 @default.
- W2892867595 cites W1967046363 @default.
- W2892867595 cites W1968155895 @default.
- W2892867595 cites W196988766 @default.
- W2892867595 cites W1970533259 @default.
- W2892867595 cites W1975641065 @default.
- W2892867595 cites W1977234648 @default.
- W2892867595 cites W1978896880 @default.
- W2892867595 cites W1979044083 @default.
- W2892867595 cites W1979096652 @default.
- W2892867595 cites W1979365023 @default.
- W2892867595 cites W1980311878 @default.
- W2892867595 cites W1982316939 @default.
- W2892867595 cites W1982634981 @default.
- W2892867595 cites W1984869996 @default.
- W2892867595 cites W1985343246 @default.
- W2892867595 cites W1987923616 @default.
- W2892867595 cites W1991152877 @default.
- W2892867595 cites W1993993136 @default.
- W2892867595 cites W1994568780 @default.
- W2892867595 cites W1994830244 @default.
- W2892867595 cites W1995280544 @default.
- W2892867595 cites W1996948576 @default.
- W2892867595 cites W1997491649 @default.
- W2892867595 cites W1998563588 @default.
- W2892867595 cites W1999395829 @default.
- W2892867595 cites W2000770184 @default.
- W2892867595 cites W2001107975 @default.
- W2892867595 cites W2002664835 @default.
- W2892867595 cites W2004349171 @default.
- W2892867595 cites W2007197518 @default.
- W2892867595 cites W2007953331 @default.
- W2892867595 cites W2008453647 @default.
- W2892867595 cites W2009901431 @default.
- W2892867595 cites W2010158663 @default.
- W2892867595 cites W2011531331 @default.
- W2892867595 cites W2011771819 @default.
- W2892867595 cites W2011851536 @default.
- W2892867595 cites W2012455832 @default.
- W2892867595 cites W2012910148 @default.
- W2892867595 cites W2017405704 @default.
- W2892867595 cites W2020410272 @default.
- W2892867595 cites W2020952616 @default.
- W2892867595 cites W2026896596 @default.
- W2892867595 cites W2030539829 @default.
- W2892867595 cites W2030787126 @default.
- W2892867595 cites W2033617297 @default.
- W2892867595 cites W2033738580 @default.
- W2892867595 cites W2035653659 @default.
- W2892867595 cites W2035887863 @default.
- W2892867595 cites W2036796078 @default.
- W2892867595 cites W2038182267 @default.
- W2892867595 cites W2039872800 @default.
- W2892867595 cites W2047259732 @default.
- W2892867595 cites W2047553372 @default.
- W2892867595 cites W2048181000 @default.
- W2892867595 cites W2049460016 @default.
- W2892867595 cites W2050814939 @default.
- W2892867595 cites W2053290656 @default.
- W2892867595 cites W2053367250 @default.
- W2892867595 cites W2054939283 @default.
- W2892867595 cites W2055123265 @default.
- W2892867595 cites W2055652253 @default.
- W2892867595 cites W2056311398 @default.
- W2892867595 cites W2056514603 @default.
- W2892867595 cites W2056539903 @default.
- W2892867595 cites W2060164934 @default.
- W2892867595 cites W2063556996 @default.
- W2892867595 cites W2064253775 @default.
- W2892867595 cites W2064575305 @default.
- W2892867595 cites W2067267561 @default.
- W2892867595 cites W2068334330 @default.
- W2892867595 cites W2068872768 @default.
- W2892867595 cites W2069456174 @default.
- W2892867595 cites W2069893872 @default.
- W2892867595 cites W2076540828 @default.