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• W2892869104 abstract "Hydrogen deuterium exchange (HDX) coupled to mass spectrometry (MS) is a well-established technique employed in the field of structural MS to probe the solvent accessibility, dynamics and hydrogen bonding of backbone amides in proteins. By contrast, fast photochemical oxidation of proteins (FPOP) uses hydroxyl radicals, liberated from the photolysis of hydrogen peroxide, to covalently label solvent accessible amino acid side chains on the microsecond-millisecond timescale. Here, we use these two techniques to study the structural and dynamical differences between the protein β2-microglobulin (β2m) and its amyloidogenic truncation variant, ΔN6. We show that HDX and FPOP highlight structural/dynamical differences in regions of the proteins, localised to the region surrounding the N-terminal truncation. Further, we demonstrate that, with carefully optimised LC-MS conditions, FPOP data can probe solvent accessibility at the sub-amino acid level, and that these data can be interpreted meaningfully to gain more detailed understanding of the local environment and orientation of the side chains in protein structures." @default.
• W2892869104 created "2018-10-05" @default.
• W2892869104 creator A5061774042 @default.
• W2892869104 creator A5073277649 @default.
• W2892869104 creator A5074934123 @default.
• W2892869104 creator A5086294886 @default.
• W2892869104 date "2018-09-28" @default.
• W2892869104 modified "2023-10-16" @default.
• W2892869104 title "Comparing Hydrogen Deuterium Exchange and Fast Photochemical Oxidation of Proteins: a Structural Characterisation of Wild-Type and ΔN6 β₂-Microglobulin" @default.
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• W2892869104 doi "https://doi.org/10.1007/s13361-018-2067-y" @default.
• W2892869104 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6276068" @default.
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• W2892869104 hasPublicationYear "2018" @default.
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