Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892871007> ?p ?o ?g. }
- W2892871007 endingPage "2939" @default.
- W2892871007 startingPage "2939" @default.
- W2892871007 abstract "Functional maintenance of the mammalian main olfactory epithelium (MOE) is challenging because of its direct exposure to a wide spectrum of environmental chemicals. We previously reported that transient receptor potential channel M5-expressing microvillous cells (TRPM5-MCs) in the MOE play an important role in olfactory maintenance. To investigate the underpinning mechanisms, we exposed transcription factor Skn-1a knockout (Skn-1a−/−) mice lacking TRPM5-MCs, and TRPM5-GFP mice to either vehicle (water) or a mixture of odorous chemicals and chitin for two weeks and analyzed the expression of olfactory signaling proteins using immunolabeling and neurotrophin (NT) and NT receptor (NTR) gene transcripts using real-time quantitative PCR. The chemical exposure did not significantly attenuate the immunolabeling of olfactory signaling proteins. Vehicle-exposed Skn-1a−/− and TRPM5-GFP mice expressed similar levels of NT and NTR gene transcripts in the MOE and olfactory bulb. Chemical exposure significantly increased MOE expression of p75NTR in Skn-1a−/− mice, while p75NTR expression was reduced in TRPM5-GFP mice, as compared to vehicle-exposed mice. Additionally, our RNA in situ hybridization analysis and immunolabeling confirmed MOE expression of most NTs and NTRs. Together, these results indicate that TRPM5-MCs and chemical exposure influence expression of some NTs and NTRs in the MOE and olfactory bulb (OB)." @default.
- W2892871007 created "2018-10-05" @default.
- W2892871007 creator A5007812280 @default.
- W2892871007 creator A5013377621 @default.
- W2892871007 creator A5044870711 @default.
- W2892871007 creator A5047693423 @default.
- W2892871007 creator A5054742223 @default.
- W2892871007 creator A5088852163 @default.
- W2892871007 date "2018-09-27" @default.
- W2892871007 modified "2023-10-18" @default.
- W2892871007 title "Chemical Exposure-Induced Changes in the Expression of Neurotrophins and Their Receptors in the Main Olfactory System of Mice Lacking TRPM5-Expressing Microvillous Cells" @default.
- W2892871007 cites W1539777819 @default.
- W2892871007 cites W1604616389 @default.
- W2892871007 cites W1855876498 @default.
- W2892871007 cites W1907582838 @default.
- W2892871007 cites W1964639675 @default.
- W2892871007 cites W1965845823 @default.
- W2892871007 cites W1969479602 @default.
- W2892871007 cites W1969722416 @default.
- W2892871007 cites W1970033499 @default.
- W2892871007 cites W1981447431 @default.
- W2892871007 cites W1989456242 @default.
- W2892871007 cites W1990362540 @default.
- W2892871007 cites W1993508399 @default.
- W2892871007 cites W2001321749 @default.
- W2892871007 cites W2006027345 @default.
- W2892871007 cites W2006256951 @default.
- W2892871007 cites W2006294052 @default.
- W2892871007 cites W2011932296 @default.
- W2892871007 cites W2012423618 @default.
- W2892871007 cites W2014995223 @default.
- W2892871007 cites W2022662543 @default.
- W2892871007 cites W2032019813 @default.
- W2892871007 cites W2036668142 @default.
- W2892871007 cites W2047815408 @default.
- W2892871007 cites W2048847556 @default.
- W2892871007 cites W2049038291 @default.
- W2892871007 cites W2049821282 @default.
- W2892871007 cites W2055280186 @default.
- W2892871007 cites W2061050597 @default.
- W2892871007 cites W2061298800 @default.
- W2892871007 cites W2061490719 @default.
- W2892871007 cites W2065142466 @default.
- W2892871007 cites W2066457796 @default.
- W2892871007 cites W2068600262 @default.
- W2892871007 cites W2071358176 @default.
- W2892871007 cites W2071638524 @default.
- W2892871007 cites W2073625719 @default.
- W2892871007 cites W2080374092 @default.
- W2892871007 cites W2087085993 @default.
- W2892871007 cites W2091214653 @default.
- W2892871007 cites W2092288031 @default.
- W2892871007 cites W2092921145 @default.
- W2892871007 cites W2097816843 @default.
- W2892871007 cites W2098090155 @default.
- W2892871007 cites W2101821836 @default.
- W2892871007 cites W2102252670 @default.
- W2892871007 cites W2103483073 @default.
- W2892871007 cites W2107277218 @default.
- W2892871007 cites W2110795584 @default.
- W2892871007 cites W2137863553 @default.
- W2892871007 cites W2139350288 @default.
- W2892871007 cites W2139565721 @default.
- W2892871007 cites W2144435898 @default.
- W2892871007 cites W2148450564 @default.
- W2892871007 cites W2192080449 @default.
- W2892871007 cites W2304839922 @default.
- W2892871007 cites W2318563828 @default.
- W2892871007 cites W2327551777 @default.
- W2892871007 cites W2341407784 @default.
- W2892871007 cites W2418629764 @default.
- W2892871007 cites W2512311410 @default.
- W2892871007 cites W2528449563 @default.
- W2892871007 cites W2558181194 @default.
- W2892871007 cites W2585270887 @default.
- W2892871007 cites W2622254410 @default.
- W2892871007 cites W2790658640 @default.
- W2892871007 cites W2794179610 @default.
- W2892871007 doi "https://doi.org/10.3390/ijms19102939" @default.
- W2892871007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6213160" @default.
- W2892871007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30261693" @default.
- W2892871007 hasPublicationYear "2018" @default.
- W2892871007 type Work @default.
- W2892871007 sameAs 2892871007 @default.
- W2892871007 citedByCount "5" @default.
- W2892871007 countsByYear W28928710072020 @default.
- W2892871007 countsByYear W28928710072021 @default.
- W2892871007 countsByYear W28928710072022 @default.
- W2892871007 crossrefType "journal-article" @default.
- W2892871007 hasAuthorship W2892871007A5007812280 @default.
- W2892871007 hasAuthorship W2892871007A5013377621 @default.
- W2892871007 hasAuthorship W2892871007A5044870711 @default.
- W2892871007 hasAuthorship W2892871007A5047693423 @default.
- W2892871007 hasAuthorship W2892871007A5054742223 @default.
- W2892871007 hasAuthorship W2892871007A5088852163 @default.
- W2892871007 hasBestOaLocation W28928710071 @default.
- W2892871007 hasConcept C153911025 @default.
- W2892871007 hasConcept C169760540 @default.