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• W2892874345 abstract "Suramin (Sur) acts as an ecto -NTPDase inhibitor in Trypanosoma cruzi and a P2-purinoceptor antagonist in mammalian cells. Although the potent antitrypanosomal effect of Sur has been shown in vitro , limited evidence in vivo suggests that this drug can be dangerous to T. cruzi -infected hosts. Therefore, we investigated the dose-dependent effect of Sur-based chemotherapy in a murine model of Chagas disease. Seventy uninfected and T. cruzi -infected male C57BL/6 mice were randomized into five groups: SAL = uninfected; INF = infected; SR5, SR10, and SR20 = infected treated with 5, 10, or 20 mg/kg Sur. In addition to its effect on blood and heart parasitism, the impact of Sur-based chemotherapy on leucocytes myocardial infiltration, cytokine levels, antioxidant defenses, reactive tissue damage, and mortality was analyzed. Our results indicated that animals treated with 10 and 20 mg/kg Sur were disproportionally susceptible to T. cruzi , exhibiting increased parasitemia and cardiac parasitism (amastigote nests and parasite load ( T. cruzi DNA)), intense protein, lipid and DNA oxidation, marked myocarditis, and mortality. Animals treated with Sur also exhibited reduced levels of nonprotein antioxidants. However, the upregulation of catalase, superoxide dismutase, and glutathione-S-transferase was insufficient to counteract reactive tissue damage and pathological myocardial remodeling. It is still poorly understood whether Sur exerts a negative impact on the purinergic signaling of T. cruzi -infected host cells. However, our findings clearly demonstrated that through enhanced parasitism, inflammation, and reactive tissue damage, Sur-based chemotherapy contributes to aggravating myocarditis and increasing mortality rates in T. cruzi -infected mice, contradicting the supposed relevance attributed to this drug for the treatment of Chagas disease." @default.
• W2892874345 created "2018-10-05" @default.
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• W2892874345 date "2018-09-30" @default.
• W2892874345 modified "2023-10-15" @default.
• W2892874345 title "Purinergic Antagonist Suramin Aggravates Myocarditis and Increases Mortality by Enhancing Parasitism, Inflammation, and Reactive Tissue Damage in<i>Trypanosoma cruzi</i>-Infected Mice" @default.
• W2892874345 cites W1435064247 @default.
• W2892874345 cites W1501866657 @default.
• W2892874345 cites W1567614586 @default.
• W2892874345 cites W1581414347 @default.
• W2892874345 cites W1590457525 @default.
• W2892874345 cites W1812337944 @default.
• W2892874345 cites W191793640 @default.
• W2892874345 cites W1964390988 @default.
• W2892874345 cites W1973308380 @default.
• W2892874345 cites W1978341235 @default.
• W2892874345 cites W1993057836 @default.
• W2892874345 cites W1998706031 @default.
• W2892874345 cites W2000939785 @default.
• W2892874345 cites W2001427429 @default.
• W2892874345 cites W2002372051 @default.
• W2892874345 cites W2003612972 @default.
• W2892874345 cites W2006846516 @default.
• W2892874345 cites W2007066202 @default.
• W2892874345 cites W2009710672 @default.
• W2892874345 cites W2015414741 @default.
• W2892874345 cites W2016114644 @default.
• W2892874345 cites W2017094761 @default.
• W2892874345 cites W2019621761 @default.
• W2892874345 cites W2020087523 @default.
• W2892874345 cites W2034643457 @default.
• W2892874345 cites W2035949542 @default.
• W2892874345 cites W2042415770 @default.
• W2892874345 cites W2046784759 @default.
• W2892874345 cites W2055754434 @default.
• W2892874345 cites W2056528064 @default.
• W2892874345 cites W2059643569 @default.
• W2892874345 cites W2064907757 @default.
• W2892874345 cites W2067068975 @default.
• W2892874345 cites W2070549262 @default.
• W2892874345 cites W2076028437 @default.
• W2892874345 cites W2076614810 @default.
• W2892874345 cites W2079057787 @default.
• W2892874345 cites W2083332915 @default.
• W2892874345 cites W2084059035 @default.
• W2892874345 cites W2091702594 @default.
• W2892874345 cites W2100717661 @default.
• W2892874345 cites W2101537600 @default.
• W2892874345 cites W2104807853 @default.
• W2892874345 cites W2108186280 @default.
• W2892874345 cites W2121411268 @default.
• W2892874345 cites W2123423422 @default.
• W2892874345 cites W2125289626 @default.
• W2892874345 cites W2125924084 @default.
• W2892874345 cites W2128635872 @default.
• W2892874345 cites W2138200691 @default.
• W2892874345 cites W2146754354 @default.
• W2892874345 cites W2164544723 @default.
• W2892874345 cites W2167755309 @default.
• W2892874345 cites W2169920873 @default.
• W2892874345 cites W2254057616 @default.
• W2892874345 cites W2292051166 @default.
• W2892874345 cites W2327321986 @default.
• W2892874345 cites W2527800795 @default.
• W2892874345 cites W2562813708 @default.
• W2892874345 cites W2580349862 @default.
• W2892874345 cites W2592297003 @default.
• W2892874345 cites W2616980782 @default.
• W2892874345 cites W2623865758 @default.
• W2892874345 cites W2771163808 @default.
• W2892874345 cites W2785180483 @default.
• W2892874345 cites W2801101174 @default.
• W2892874345 cites W2801968742 @default.
• W2892874345 cites W4210980497 @default.
• W2892874345 cites W4235938477 @default.
• W2892874345 cites W4251651506 @default.
• W2892874345 cites W4293247451 @default.
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• W2892874345 doi "https://doi.org/10.1155/2018/7385639" @default.
• W2892874345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6186315" @default.
• W2892874345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30364017" @default.
• W2892874345 hasPublicationYear "2018" @default.
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