FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892875435> ?p ?o ?g. }

• W2892875435 endingPage "6427" @default.
• W2892875435 startingPage "6414" @default.
• W2892875435 abstract "This study revealed that iturin A-like lipopeptides produced by Bacillus subtillis induced both paraptosis and apoptosis in heterogeneous human epithelial colorectal adenocarcinoma (Caco-2) cells. Autophagy was simultaneously induced in Caco-2 cells treated with iturin A-like lipopeptides at the early stage and inhibited at the later stage. A western blot analysis showed that the lipopeptides induced apoptosis in Caco-2 cells via a mitochondrial-dependent pathway, as indicated by upregulated expression of the apoptotic genes bax and bad and downregulated expression of the antiapoptotic gene bcl-2. The induction of paraptosis in Caco-2 cells was indicated by the occurrence of many cytoplasmic vacuoles accompanied by endoplasmic reticulum (ER) dilatation and mitochondrial swelling and dysfunction. ER stress also occurred with significant increases in reactive oxygen species and Ca2+ levels in cells. Autophagy was detected by a transmission electron microscopy analysis and by upregulated expression of LC3-II and downregulated expression of LC3-I. The inhibition of autophagy at the later stage was shown by upregulated expression of p62. This study revealed the capability of iturin A-like B. subtilis lipopeptides to simultaneously execute antitumor potential via multiple pathways." @default.
• W2892875435 created "2018-10-05" @default.
• W2892875435 creator A5000946762 @default.
• W2892875435 creator A5016748852 @default.
• W2892875435 creator A5030370384 @default.
• W2892875435 creator A5031660991 @default.
• W2892875435 creator A5045398749 @default.
• W2892875435 creator A5050199446 @default.
• W2892875435 creator A5050303922 @default.
• W2892875435 creator A5063481044 @default.
• W2892875435 creator A5068994684 @default.
• W2892875435 creator A5074590231 @default.
• W2892875435 date "2018-09-21" @default.
• W2892875435 modified "2023-10-16" @default.
• W2892875435 title "Iturin A‐like lipopeptides from <i>Bacillus subtilis</i> trigger apoptosis, paraptosis, and autophagy in Caco‐2 cells" @default.
• W2892875435 cites W1834989319 @default.
• W2892875435 cites W1844865274 @default.
• W2892875435 cites W1979656224 @default.
• W2892875435 cites W1979794176 @default.
• W2892875435 cites W1980912158 @default.
• W2892875435 cites W1982728351 @default.
• W2892875435 cites W1990098732 @default.
• W2892875435 cites W1990538434 @default.
• W2892875435 cites W1991158104 @default.
• W2892875435 cites W1991303444 @default.
• W2892875435 cites W1993403596 @default.
• W2892875435 cites W2000333623 @default.
• W2892875435 cites W2001574699 @default.
• W2892875435 cites W2020127174 @default.
• W2892875435 cites W2024236843 @default.
• W2892875435 cites W2043360750 @default.
• W2892875435 cites W2075508190 @default.
• W2892875435 cites W2090915163 @default.
• W2892875435 cites W2091300408 @default.
• W2892875435 cites W2096308078 @default.
• W2892875435 cites W2129141930 @default.
• W2892875435 cites W2129894086 @default.
• W2892875435 cites W2135600559 @default.
• W2892875435 cites W2140600636 @default.
• W2892875435 cites W2154155095 @default.
• W2892875435 cites W2274774578 @default.
• W2892875435 cites W2330699543 @default.
• W2892875435 cites W2331099673 @default.
• W2892875435 cites W2339647153 @default.
• W2892875435 cites W2403672650 @default.
• W2892875435 cites W2520484243 @default.
• W2892875435 cites W2528028583 @default.
• W2892875435 cites W2529857084 @default.
• W2892875435 cites W2595674614 @default.
• W2892875435 cites W2789903849 @default.
• W2892875435 cites W297380522 @default.
• W2892875435 cites W907918848 @default.
• W2892875435 cites W936159182 @default.
• W2892875435 doi "https://doi.org/10.1002/jcp.27377" @default.
• W2892875435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30238995" @default.
• W2892875435 hasPublicationYear "2018" @default.
• W2892875435 type Work @default.
• W2892875435 sameAs 2892875435 @default.
• W2892875435 citedByCount "39" @default.
• W2892875435 countsByYear W28928754352019 @default.
• W2892875435 countsByYear W28928754352020 @default.
• W2892875435 countsByYear W28928754352021 @default.
• W2892875435 countsByYear W28928754352022 @default.
• W2892875435 countsByYear W28928754352023 @default.
• W2892875435 crossrefType "journal-article" @default.
• W2892875435 hasAuthorship W2892875435A5000946762 @default.
• W2892875435 hasAuthorship W2892875435A5016748852 @default.
• W2892875435 hasAuthorship W2892875435A5030370384 @default.
• W2892875435 hasAuthorship W2892875435A5031660991 @default.
• W2892875435 hasAuthorship W2892875435A5045398749 @default.
• W2892875435 hasAuthorship W2892875435A5050199446 @default.
• W2892875435 hasAuthorship W2892875435A5050303922 @default.
• W2892875435 hasAuthorship W2892875435A5063481044 @default.
• W2892875435 hasAuthorship W2892875435A5068994684 @default.
• W2892875435 hasAuthorship W2892875435A5074590231 @default.
• W2892875435 hasConcept C102568950 @default.
• W2892875435 hasConcept C104317684 @default.
• W2892875435 hasConcept C127561419 @default.
• W2892875435 hasConcept C153911025 @default.
• W2892875435 hasConcept C158617107 @default.
• W2892875435 hasConcept C185592680 @default.
• W2892875435 hasConcept C190062978 @default.
• W2892875435 hasConcept C190283241 @default.
• W2892875435 hasConcept C203522944 @default.
• W2892875435 hasConcept C2776415932 @default.
• W2892875435 hasConcept C2777272437 @default.
• W2892875435 hasConcept C523546767 @default.
• W2892875435 hasConcept C54355233 @default.
• W2892875435 hasConcept C55493867 @default.
• W2892875435 hasConcept C86803240 @default.
• W2892875435 hasConcept C89423630 @default.
• W2892875435 hasConcept C95444343 @default.
• W2892875435 hasConceptScore W2892875435C102568950 @default.
• W2892875435 hasConceptScore W2892875435C104317684 @default.
• W2892875435 hasConceptScore W2892875435C127561419 @default.
• W2892875435 hasConceptScore W2892875435C153911025 @default.
• W2892875435 hasConceptScore W2892875435C158617107 @default.
• W2892875435 hasConceptScore W2892875435C185592680 @default.

• next