Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892878546> ?p ?o ?g. }
- W2892878546 endingPage "310" @default.
- W2892878546 startingPage "291" @default.
- W2892878546 abstract "The quest to better understand the pathophysiology of Parkinson’s disease (PD) and to find new therapies to provide greater relief to affected patients continues. The use of animal models of PD has been invaluable in the process. Here, we review, through a historical lens, some of the contribution of the 6-hydroxydopamine-lesioned rat and of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned nonhuman primate, in refining our understanding of PD and its treatment-related complications. We examine the mechanisms underlying the toxicity of 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, and then explore some of the advances at the molecular, pharmacological, electrophysiological and surgical levels made while experimenting on these animal models. We also discuss behavioural testing that can be performed with these animal models and highlight some of their limitations." @default.
- W2892878546 created "2018-10-05" @default.
- W2892878546 creator A5006406921 @default.
- W2892878546 creator A5055028529 @default.
- W2892878546 creator A5067369587 @default.
- W2892878546 creator A5084310254 @default.
- W2892878546 date "2019-06-01" @default.
- W2892878546 modified "2023-10-14" @default.
- W2892878546 title "Classic animal models of Parkinson’s disease: a historical perspective" @default.
- W2892878546 cites W149565960 @default.
- W2892878546 cites W1505206211 @default.
- W2892878546 cites W1522510037 @default.
- W2892878546 cites W1526420193 @default.
- W2892878546 cites W1532481675 @default.
- W2892878546 cites W1542863295 @default.
- W2892878546 cites W1548245829 @default.
- W2892878546 cites W1567888745 @default.
- W2892878546 cites W1568165441 @default.
- W2892878546 cites W1587395327 @default.
- W2892878546 cites W1700865237 @default.
- W2892878546 cites W175006040 @default.
- W2892878546 cites W1768450208 @default.
- W2892878546 cites W1786270771 @default.
- W2892878546 cites W1832682301 @default.
- W2892878546 cites W1965095016 @default.
- W2892878546 cites W1966260988 @default.
- W2892878546 cites W1967099480 @default.
- W2892878546 cites W1967282017 @default.
- W2892878546 cites W1967282079 @default.
- W2892878546 cites W1967348306 @default.
- W2892878546 cites W1969609780 @default.
- W2892878546 cites W1969800514 @default.
- W2892878546 cites W1970083936 @default.
- W2892878546 cites W1970095022 @default.
- W2892878546 cites W1970393643 @default.
- W2892878546 cites W1970914521 @default.
- W2892878546 cites W1971258758 @default.
- W2892878546 cites W1971698832 @default.
- W2892878546 cites W1972106608 @default.
- W2892878546 cites W1972146241 @default.
- W2892878546 cites W1973558218 @default.
- W2892878546 cites W1974546036 @default.
- W2892878546 cites W1974924674 @default.
- W2892878546 cites W197581571 @default.
- W2892878546 cites W1976836813 @default.
- W2892878546 cites W1976856793 @default.
- W2892878546 cites W1977198160 @default.
- W2892878546 cites W1977755901 @default.
- W2892878546 cites W1980050662 @default.
- W2892878546 cites W1980461727 @default.
- W2892878546 cites W1980857402 @default.
- W2892878546 cites W1981609060 @default.
- W2892878546 cites W1981819503 @default.
- W2892878546 cites W1982819368 @default.
- W2892878546 cites W1982864501 @default.
- W2892878546 cites W1982928559 @default.
- W2892878546 cites W1983772312 @default.
- W2892878546 cites W1984399399 @default.
- W2892878546 cites W1985385524 @default.
- W2892878546 cites W1985423204 @default.
- W2892878546 cites W1985686554 @default.
- W2892878546 cites W1985744868 @default.
- W2892878546 cites W1986245765 @default.
- W2892878546 cites W1986278187 @default.
- W2892878546 cites W1986440084 @default.
- W2892878546 cites W1986592378 @default.
- W2892878546 cites W1986694134 @default.
- W2892878546 cites W1986716278 @default.
- W2892878546 cites W1986776141 @default.
- W2892878546 cites W1987123703 @default.
- W2892878546 cites W1987193373 @default.
- W2892878546 cites W1989350751 @default.
- W2892878546 cites W1989475543 @default.
- W2892878546 cites W1989968365 @default.
- W2892878546 cites W1990280414 @default.
- W2892878546 cites W1990654593 @default.
- W2892878546 cites W1991337007 @default.
- W2892878546 cites W1991532308 @default.
- W2892878546 cites W1991955710 @default.
- W2892878546 cites W1992238782 @default.
- W2892878546 cites W199354732 @default.
- W2892878546 cites W1993831386 @default.
- W2892878546 cites W1994102729 @default.
- W2892878546 cites W1994373252 @default.
- W2892878546 cites W1997692493 @default.
- W2892878546 cites W1998649401 @default.
- W2892878546 cites W1999018495 @default.
- W2892878546 cites W1999054588 @default.
- W2892878546 cites W1999385317 @default.
- W2892878546 cites W1999649044 @default.
- W2892878546 cites W2000728885 @default.
- W2892878546 cites W2001775202 @default.
- W2892878546 cites W2001809759 @default.
- W2892878546 cites W2002112986 @default.
- W2892878546 cites W2002287054 @default.
- W2892878546 cites W2002452414 @default.
- W2892878546 cites W2002586153 @default.
- W2892878546 cites W2002745537 @default.