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- W2892889246 endingPage "19" @default.
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- W2892889246 abstract "Triple-negative breast cancer (TNBC) does not express estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 and is characterized by its aggressive nature, lack of targets for targeted therapies, and early peak of recurrence. Due to these specific characteristics, chemotherapy does not usually yield substantial improvements and new target therapies and alternative strategies are needed. The beneficial responses of TNBC survivors to regular exercise, including a reduction in the rate of tumor growth, are becoming increasingly apparent. Physiological adaptations to exercise occur in skeletal muscle but have an impact on the entire body through systemic control of energy homeostasis and metabolism, which in turn influence the TNBC tumor microenvironment. Gaining insights into the causal mechanisms of the therapeutic cancer control properties of regular exercise is important to improve the prescription and implementation of exercise and training in TNBC survivors. Here, we provide new evidence of the effects of exercise on TNBC prevention, control, and outcomes, based on the inhibition of the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (PKB also known as Akt)/mammalian target of rapamycin (mTOR) (PI3K-Akt-mTOR) signaling. These findings have wide-ranging clinical implications for cancer treatment, including recurrence and case management." @default.
- W2892889246 created "2018-10-05" @default.
- W2892889246 creator A5000245121 @default.
- W2892889246 creator A5005894658 @default.
- W2892889246 creator A5024052930 @default.
- W2892889246 creator A5031713175 @default.
- W2892889246 creator A5040319467 @default.
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- W2892889246 creator A5062343486 @default.
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- W2892889246 creator A5064787016 @default.
- W2892889246 creator A5074715949 @default.
- W2892889246 creator A5082112497 @default.
- W2892889246 date "2018-09-30" @default.
- W2892889246 modified "2023-10-17" @default.
- W2892889246 title "New Insights into the Role of Exercise in Inhibiting mTOR Signaling in Triple-Negative Breast Cancer" @default.
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