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- W28928970 abstract "Publisher Summary This chapter discusses the role of epigenetics in immune disorders. The immune system enables the organism to resist infections and is composed of the innate or non-specific system and the adaptive or specific system. Aberrations in any part of it can lead to misdirected reactions resulting in autoimmunity where the immune system attack turns against the host tissues. Research has focused on elaborating the epigenetic regulation of the forkhead box P3—a transcriptional repressor and the master regulator of development and function of Treg cells. It has been shown that CpG motifs in the locus of Foxp3 are demethylated in Tregs in contrast to naive T cells. Furthermore, also histone modifications such as increased histone acetylation in the promoter of Foxp3 have been described in natural Tregs. Stimulation of Treg cells by ligation of TCR leads to the nuclear translocation of Foxp3 and its binding to promoters of proinflammatory IL-2 and INF-γ inducing their deacetylation and silencing, as well as to promoters of GITR, CD25, and CTLA-4 increasing their acetylation and expression which is characteristic for the functional Tregs. It was shown that Foxp3 is optimally functional when in a complex with histone acetyltransferase Tip60 and histone deacetylase HDAC7." @default.
- W28928970 created "2016-06-24" @default.
- W28928970 creator A5029329633 @default.
- W28928970 creator A5032756080 @default.
- W28928970 creator A5072111802 @default.
- W28928970 date "2011-01-01" @default.
- W28928970 modified "2023-09-26" @default.
- W28928970 title "The Role of Epigenetics in Immune Disorders" @default.
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