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- W2892905466 abstract "As a sophisticated computing unit, the pyramidal neuron requires sufficient metabolic energy to fuel its powerful computational capabilities. However, the majority of previous works focus on nonlinear integration and energy consumption in individual pyramidal neurons but seldom on the effects of metabolic energy on synaptic transmission and dendritic integration. Here, we developed biologically plausible models to simulate the synaptic transmission and dendritic integration of pyramidal neurons, exploring the relations between synaptic transmission and metabolic energy and between dendritic integration and metabolic energy. We find that synaptic energy not only drives synaptic vesicle cycle, but also participates in the regulation of this cycle. Release probability of synapses adapts to synaptic energy levels by regulating the speed of synaptic vesicle cycle. Besides, we also find that to match neural energy levels, only a part of the synapses receive presynaptic signals during a given period so that neurons have a low action potential frequency. That is, the number of simultaneously active synapses over a period of time should be adapted to neural energy levels." @default.
- W2892905466 created "2018-10-05" @default.
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- W2892905466 creator A5031949326 @default.
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- W2892905466 date "2018-09-26" @default.
- W2892905466 modified "2023-09-26" @default.
- W2892905466 title "Effects of Metabolic Energy on Synaptic Transmission and Dendritic Integration in Pyramidal Neurons" @default.
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- W2892905466 doi "https://doi.org/10.3389/fncom.2018.00079" @default.
- W2892905466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6168642" @default.
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