FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892905965> ?p ?o ?g. }

• W2892905965 endingPage "550" @default.
• W2892905965 startingPage "543" @default.
• W2892905965 abstract "Novel synthetic cannabinoids are appearing in recreational drug markets worldwide. Pharmacological characterization of these new drugs is needed to inform clinicians, toxicologists, and policy makers who monitor public health. [1-(5-Fluoropentyl)-1H-indol-3-yl](1-naphthyl)methanone (AM-2201) is an abused synthetic cannabinoid that was initially created as a research tool for investigating the endocannabinoid system. Here we measured the pharmacodynamic effects of AM-2201 in rats, and simultaneously determined plasma pharmacokinetics for the parent drug and its metabolites. Male Sprague-Dawley rats were fitted with surgically implanted temperature transponders and indwelling jugular catheters under pentobarbital anesthesia. One week later, rats received subcutaneous injection of AM-2201 (0.1, 0.3, and 1.0 mg/kg) or its vehicle, and serial blood specimens were withdrawn via catheters. Core temperatures and catalepsy were measured just prior to each blood withdrawal, and plasma was assayed for drug and metabolites using liquid chromatography-tandem mass spectrometry. We found that AM-2201 produced dose-related hypothermia and catalepsy that peaked at 2 hours and lasted up to 8 hours. AM-2201 plasma concentrations rose linearly with increasing dose and ranged from 0.14 to 67.9 µg/l. Concentrations of three metabolites, AM-2201 N-(4-hydroxypentyl) (≤0.17 µg/l), naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) N-(5-hydroxypentyl) (≤1.14 µg/l), and JWH-018 N-pentanoic acid (≤0.88 µg/l) were detectable but much lower. Peak AM-2201, JWH-018 N-(5-hydroxypentyl), and JWH-018 N-pentanoic acid concentrations occurred at 1.3, 2.4, and 6.5 hours, respectively. Concentrations of AM-2201, JWH-018 N-(5-hydroxypentyl), and JWH-018 N-pentanoic acid were negatively correlated with body temperature, but, given the low concentrations of metabolites detected, AM-2201 is likely the major contributor to pharmacodynamic effects under our experimental conditions." @default.
• W2892905965 created "2018-10-05" @default.
• W2892905965 creator A5000016116 @default.
• W2892905965 creator A5001384972 @default.
• W2892905965 creator A5004773599 @default.
• W2892905965 creator A5022661574 @default.
• W2892905965 creator A5047883179 @default.
• W2892905965 creator A5057275199 @default.
• W2892905965 date "2018-09-28" @default.
• W2892905965 modified "2023-10-17" @default.
• W2892905965 title "Pharmacodynamic Effects, Pharmacokinetics, and Metabolism of the Synthetic Cannabinoid AM-2201 in Male Rats" @default.
• W2892905965 cites W1536445278 @default.
• W2892905965 cites W1855306715 @default.
• W2892905965 cites W1893134605 @default.
• W2892905965 cites W1905181051 @default.
• W2892905965 cites W1968753875 @default.
• W2892905965 cites W1973544026 @default.
• W2892905965 cites W1978622737 @default.
• W2892905965 cites W1987155839 @default.
• W2892905965 cites W1990920353 @default.
• W2892905965 cites W2023741455 @default.
• W2892905965 cites W2024648171 @default.
• W2892905965 cites W2038784126 @default.
• W2892905965 cites W2048091175 @default.
• W2892905965 cites W2048987473 @default.
• W2892905965 cites W2059178792 @default.
• W2892905965 cites W2060528629 @default.
• W2892905965 cites W2072475603 @default.
• W2892905965 cites W2080448879 @default.
• W2892905965 cites W2090869417 @default.
• W2892905965 cites W2091638846 @default.
• W2892905965 cites W2140768805 @default.
• W2892905965 cites W2148611011 @default.
• W2892905965 cites W2153539777 @default.
• W2892905965 cites W2156324818 @default.
• W2892905965 cites W2166086733 @default.
• W2892905965 cites W2306386326 @default.
• W2892905965 cites W2345828978 @default.
• W2892905965 cites W2605228052 @default.
• W2892905965 cites W2748573918 @default.
• W2892905965 cites W2789451520 @default.
• W2892905965 doi "https://doi.org/10.1124/jpet.118.250530" @default.
• W2892905965 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6246978" @default.
• W2892905965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30266766" @default.
• W2892905965 hasPublicationYear "2018" @default.
• W2892905965 type Work @default.
• W2892905965 sameAs 2892905965 @default.
• W2892905965 citedByCount "14" @default.
• W2892905965 countsByYear W28929059652019 @default.
• W2892905965 countsByYear W28929059652020 @default.
• W2892905965 countsByYear W28929059652021 @default.
• W2892905965 countsByYear W28929059652022 @default.
• W2892905965 crossrefType "journal-article" @default.
• W2892905965 hasAuthorship W2892905965A5000016116 @default.
• W2892905965 hasAuthorship W2892905965A5001384972 @default.
• W2892905965 hasAuthorship W2892905965A5004773599 @default.
• W2892905965 hasAuthorship W2892905965A5022661574 @default.
• W2892905965 hasAuthorship W2892905965A5047883179 @default.
• W2892905965 hasAuthorship W2892905965A5057275199 @default.
• W2892905965 hasBestOaLocation W28929059651 @default.
• W2892905965 hasConcept C111113717 @default.
• W2892905965 hasConcept C112705442 @default.
• W2892905965 hasConcept C126322002 @default.
• W2892905965 hasConcept C134018914 @default.
• W2892905965 hasConcept C148001335 @default.
• W2892905965 hasConcept C149151106 @default.
• W2892905965 hasConcept C170493617 @default.
• W2892905965 hasConcept C185592680 @default.
• W2892905965 hasConcept C2776755955 @default.
• W2892905965 hasConcept C2776885963 @default.
• W2892905965 hasConcept C2777846614 @default.
• W2892905965 hasConcept C2779783865 @default.
• W2892905965 hasConcept C2780476085 @default.
• W2892905965 hasConcept C2780871563 @default.
• W2892905965 hasConcept C2780948584 @default.
• W2892905965 hasConcept C513476851 @default.
• W2892905965 hasConcept C71924100 @default.
• W2892905965 hasConcept C98274493 @default.
• W2892905965 hasConceptScore W2892905965C111113717 @default.
• W2892905965 hasConceptScore W2892905965C112705442 @default.
• W2892905965 hasConceptScore W2892905965C126322002 @default.
• W2892905965 hasConceptScore W2892905965C134018914 @default.
• W2892905965 hasConceptScore W2892905965C148001335 @default.
• W2892905965 hasConceptScore W2892905965C149151106 @default.
• W2892905965 hasConceptScore W2892905965C170493617 @default.
• W2892905965 hasConceptScore W2892905965C185592680 @default.
• W2892905965 hasConceptScore W2892905965C2776755955 @default.
• W2892905965 hasConceptScore W2892905965C2776885963 @default.
• W2892905965 hasConceptScore W2892905965C2777846614 @default.
• W2892905965 hasConceptScore W2892905965C2779783865 @default.
• W2892905965 hasConceptScore W2892905965C2780476085 @default.
• W2892905965 hasConceptScore W2892905965C2780871563 @default.
• W2892905965 hasConceptScore W2892905965C2780948584 @default.
• W2892905965 hasConceptScore W2892905965C513476851 @default.
• W2892905965 hasConceptScore W2892905965C71924100 @default.
• W2892905965 hasConceptScore W2892905965C98274493 @default.
• W2892905965 hasIssue "3" @default.
• W2892905965 hasLocation W28929059651 @default.

• next