FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892912684> ?p ?o ?g. }

• W2892912684 abstract "Prevention and treatment of drug-induced renal injury (DIRI) rely on the availability of sensitive and specific biomarkers of early kidney injury and predictive animal models of human pathophysiology. This study aimed to evaluate the potential of zebrafish larvae as translational model in metabolic profiling of DIRI. Zebrafish larvae were exposed to the lethal concentration for 10% of the larvae (LC10) or ½ LC10 of gentamicin, paracetamol and tenofovir as tenofovir disoproxil fumarate (TDF) and tenofovir (TFV). Metabolites were extracted from whole larvae and analyzed by liquid chromatography-mass spectrometry. Principal component analysis showed that drug exposition to the LC10 of paracetamol, TFV, and TDF was the main source of the variance of the data. To identify the metabolites responsible for the toxic effects of the drugs, partial least squares discriminant analyses were built between the LC10 and ½ LC10 for each drug. Features with variable importance in projection> 1.0 were selected and Venn diagrams were built to differentiate between the common and drug specific metabolites of DIRI. Creatine, tyrosine, glutamine, guanosine, hypoxanthine were identified as common metabolites, adenosine and tryptophan as paracetamol-specific and xanthine and oxidized glutathione as tenofovir-specific. Those metabolic changes can be associated with alterations in energy metabolism, xenobiotic detoxification and protein catabolism, all described in the human pathophysiology of DIRI. Thus, zebrafish proved to be a suitable model to characterize the metabolic changes associated with DIRI. This information can be useful to early diagnose DIRI and to improve our knowledge on the mechanisms of DIRI." @default.
• W2892912684 created "2018-10-05" @default.
• W2892912684 creator A5016018012 @default.
• W2892912684 creator A5034472995 @default.
• W2892912684 creator A5043252693 @default.
• W2892912684 creator A5058622754 @default.
• W2892912684 creator A5065850253 @default.
• W2892912684 creator A5076327499 @default.
• W2892912684 creator A5076501395 @default.
• W2892912684 date "2018-10-16" @default.
• W2892912684 modified "2023-09-27" @default.
• W2892912684 title "Zebrafish Larvae Are a Suitable Model to Investigate the Metabolic Phenotype of Drug-Induced Renal Tubular Injury" @default.
• W2892912684 cites W1516311606 @default.
• W2892912684 cites W1539696258 @default.
• W2892912684 cites W1552261986 @default.
• W2892912684 cites W1611854178 @default.
• W2892912684 cites W1663154925 @default.
• W2892912684 cites W1964010911 @default.
• W2892912684 cites W1969779341 @default.
• W2892912684 cites W1984031597 @default.
• W2892912684 cites W1984973860 @default.
• W2892912684 cites W1986762748 @default.
• W2892912684 cites W1992746042 @default.
• W2892912684 cites W1993729940 @default.
• W2892912684 cites W2000871541 @default.
• W2892912684 cites W2013211110 @default.
• W2892912684 cites W2014057339 @default.
• W2892912684 cites W2016571006 @default.
• W2892912684 cites W2033603499 @default.
• W2892912684 cites W2041844984 @default.
• W2892912684 cites W2044505607 @default.
• W2892912684 cites W2066976865 @default.
• W2892912684 cites W2069722312 @default.
• W2892912684 cites W2073606372 @default.
• W2892912684 cites W2073981718 @default.
• W2892912684 cites W2076122545 @default.
• W2892912684 cites W2083637865 @default.
• W2892912684 cites W2094658693 @default.
• W2892912684 cites W2123532637 @default.
• W2892912684 cites W2140867423 @default.
• W2892912684 cites W2142179124 @default.
• W2892912684 cites W2150589499 @default.
• W2892912684 cites W2150851221 @default.
• W2892912684 cites W2156563909 @default.
• W2892912684 cites W2158079337 @default.
• W2892912684 cites W2162234541 @default.
• W2892912684 cites W2169128690 @default.
• W2892912684 cites W2279949682 @default.
• W2892912684 cites W2313903357 @default.
• W2892912684 cites W2331522932 @default.
• W2892912684 cites W2336335783 @default.
• W2892912684 cites W2543821606 @default.
• W2892912684 cites W2755112980 @default.
• W2892912684 doi "https://doi.org/10.3389/fphar.2018.01193" @default.
• W2892912684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6232664" @default.
• W2892912684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30459607" @default.
• W2892912684 hasPublicationYear "2018" @default.
• W2892912684 type Work @default.
• W2892912684 sameAs 2892912684 @default.
• W2892912684 citedByCount "12" @default.
• W2892912684 countsByYear W28929126842019 @default.
• W2892912684 countsByYear W28929126842020 @default.
• W2892912684 countsByYear W28929126842021 @default.
• W2892912684 countsByYear W28929126842022 @default.
• W2892912684 countsByYear W28929126842023 @default.
• W2892912684 crossrefType "journal-article" @default.
• W2892912684 hasAuthorship W2892912684A5016018012 @default.
• W2892912684 hasAuthorship W2892912684A5034472995 @default.
• W2892912684 hasAuthorship W2892912684A5043252693 @default.
• W2892912684 hasAuthorship W2892912684A5058622754 @default.
• W2892912684 hasAuthorship W2892912684A5065850253 @default.
• W2892912684 hasAuthorship W2892912684A5076327499 @default.
• W2892912684 hasAuthorship W2892912684A5076501395 @default.
• W2892912684 hasBestOaLocation W28929126841 @default.
• W2892912684 hasConcept C2780035454 @default.
• W2892912684 hasConcept C71924100 @default.
• W2892912684 hasConcept C86803240 @default.
• W2892912684 hasConcept C89311334 @default.
• W2892912684 hasConcept C98274493 @default.
• W2892912684 hasConceptScore W2892912684C2780035454 @default.
• W2892912684 hasConceptScore W2892912684C71924100 @default.
• W2892912684 hasConceptScore W2892912684C86803240 @default.
• W2892912684 hasConceptScore W2892912684C89311334 @default.
• W2892912684 hasConceptScore W2892912684C98274493 @default.
• W2892912684 hasFunder F4320323335 @default.
• W2892912684 hasFunder F4320334779 @default.
• W2892912684 hasLocation W28929126841 @default.
• W2892912684 hasLocation W28929126842 @default.
• W2892912684 hasLocation W28929126843 @default.
• W2892912684 hasLocation W28929126844 @default.
• W2892912684 hasLocation W28929126845 @default.
• W2892912684 hasLocation W28929126846 @default.
• W2892912684 hasOpenAccess W2892912684 @default.
• W2892912684 hasPrimaryLocation W28929126841 @default.
• W2892912684 hasRelatedWork W1603416295 @default.
• W2892912684 hasRelatedWork W1977781436 @default.
• W2892912684 hasRelatedWork W2050021663 @default.
• W2892912684 hasRelatedWork W211573666 @default.
• W2892912684 hasRelatedWork W2124466768 @default.
• W2892912684 hasRelatedWork W2159890448 @default.

• next