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- W2892913459 abstract "Ante la creciente resistencia bacteriana a los antibióticos es necesario determinarla de manera local para servir de guía en el manejo clínico. El propósito de este estudio fue caracterizar el patrón de sensibilidad antibiótica en casos de infecciones oculares en una institución oftalmológica de tercer nivel en Floridablanca (Colombia). Estudio observacional de corte transversal en el cual se analizaron los informes de cultivo y antibiograma de muestras tomadas de casos de conjuntivitis, queratitis infecciosas y endoftalmitis entre enero de 2013 y junio del 2016. Ochocientas treinta y tres muestras fueron positivas para bacterias. Considerando microorganismos tanto grampositivos como gramnegativos, la gentamicina, la tobramicina y la ciprofloxacina mostraron tasas de resistencia altas (64,4; 40,3% y 29,1%). La moxifloxacina, la vancomicina, el imipenem y la gatifloxacina mostraron bajos porcentajes de resistencia: 2,6; 2,1; 0,6 y 0,4% respectivamente. Al comparar los resultados con estudios previos en nuestra institución se evidenció una disminución de la sensibilidad a las quinolonas de cuarta generación y al imipenem, especialmente dentro de los gramnegativos. Las quinolonas de cuarta generación, el imipenem y la vancomicina siguen teniendo in vitro una baja resistencia de las bacterias causantes de infecciones oculares. Sin embargo, se evidenció una tendencia al incremento de la resistencia de las bacterias gramnegativas. Se deben tomar medidas para intentar controlar este fenómeno, y pensar en posibles alternativas de terapia antimicrobiana ante infecciones causadas por estos microorganismos. In view of the increasing bacterial resistance to antibiotics, it is necessary to determine it locally in order to serve as a guide in clinical management. The purpose of this study was to characterise the pattern of antibiotic sensitivity in cases of eye infections in a third level ophthalmological institution in Floridablanca (Colombia). An observational cross-sectional study in which an analysis was made of the culture and antibiogram reports of specimens taken from cases of conjunctivitis, infectious keratitis, and endophthalmitis between January 2013 and June 2016. A total of 833 specimens were positive for bacteria. Considering both gram-positive and gram-negative microorganisms gentamicin, tobramycin, and ciprofloxacin showed high resistance rates (64.4%, 40.3%, and 29.1%, respectively). Moxifloxacin, vancomycin, imipenem, and gatifloxacin showed low percentages of resistance: 2.6%, 2.1%, 0.6%, and 0.4%, respectively. When comparing the results with previous studies in our institution, there was a decrease in sensitivity to the fourth-generation quinolones and imipenem, especially within the gram-negative ones. Fourth generation quinolones, imipenem and vancomycin continue to have a low in vitro resistance to bacteria that cause eye infections. However, there was a tendency to an increase in the resistance of gram-negative bacteria. Measures should be taken to try to control this phenomenon, and consider possible antimicrobial therapy alternatives to infections caused by these microorganisms." @default.
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- W2892913459 date "2019-01-01" @default.
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- W2892913459 title "Perfil de resistencia antibiótica en infecciones oculares en un centro de referencia en Floridablanca, Colombia" @default.
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- W2892913459 doi "https://doi.org/10.1016/j.oftal.2018.07.003" @default.
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