Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892914045> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2892914045 endingPage "75" @default.
- W2892914045 startingPage "68" @default.
- W2892914045 abstract "Curcuma Longa Radix (Huangsiyujin in Chinese, HSYJ) has been used in clinical for thousands of years as a traditional Chinese medicine (TCM) and has the effects of invigorating the blood circulation, relieving pain, promoting qi circulation and relieving depression, besides, it is able to clear heart heat and cool blood and cure jaundice. The study aims to determine the active fractions of HSYJ for promotion of blood circulation and relief of pain, and to identify their chemical constituents. HSYJ was extracted by the systematic solvent method. The effects of promoting blood circulation and relieving pain were determined by measuring pain threshold (hot-plate test), latency of twisting and writhing times (acetic acid induced writhing test), and hemorheology of mice. Chemical constituents of the extractive fractions were analyzed by Gas Chromatography-Mass Spectrometer (GC-MS) or High Performance Liquid Chromatography (HPLC). The results showed that five fractions (volatile oil fraction, petroleum ether fraction, ethyl acetate fraction, 1-butanol fraction and water fraction) all could increase pain threshold, prolong latency of twisting, decrease the writhing times and influence hemorheology. However, the effects of the volatile oil fraction and ethyl acetate fraction were better than other fractions. Three constituents, namely bisdesmethoxycurum, desmethoxycurumin and curcumin were identified from the active fractions by comparing with standard preparation through HPLC analysis. Forty-five compounds including aR-Turmerone, Curlone, Tumerone, Cyclohexene,1-methyl-4-(1-methylethylidene)-, trans-Sesquisabinene hydrate, (E)-Atlantone, α-curcumene and Zingiberene were identified from the volatile oil fraction by GC-MS. HSYJ possessed the effect of promoting blood circulation and relieving pain. Curcumins and their derivatives were the major constituents and might be the main bioactive ingredients for the promotion of blood circulation and relief of pain. The study provided evidence and formed a basis for the establishment of HSYJ comprehensive quality evaluation system related to traditional efficacy. It is beneficial to the quality control of HSYJ and its proprietary Chinese medicine." @default.
- W2892914045 created "2018-10-05" @default.
- W2892914045 creator A5000811510 @default.
- W2892914045 creator A5002262798 @default.
- W2892914045 creator A5003062724 @default.
- W2892914045 creator A5039987256 @default.
- W2892914045 creator A5047919770 @default.
- W2892914045 creator A5057154885 @default.
- W2892914045 creator A5062919697 @default.
- W2892914045 creator A5064495395 @default.
- W2892914045 creator A5087741427 @default.
- W2892914045 date "2019-04-01" @default.
- W2892914045 modified "2023-10-16" @default.
- W2892914045 title "Screening of active fractions from Curcuma Longa Radix isolated by HPLC and GC-MS for promotion of blood circulation and relief of pain" @default.
- W2892914045 cites W1990483354 @default.
- W2892914045 cites W1991606775 @default.
- W2892914045 cites W2027735586 @default.
- W2892914045 cites W2028822847 @default.
- W2892914045 cites W2037690301 @default.
- W2892914045 cites W2061723277 @default.
- W2892914045 cites W2150396732 @default.
- W2892914045 cites W2162939239 @default.
- W2892914045 doi "https://doi.org/10.1016/j.jep.2018.09.035" @default.
- W2892914045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30268652" @default.
- W2892914045 hasPublicationYear "2019" @default.
- W2892914045 type Work @default.
- W2892914045 sameAs 2892914045 @default.
- W2892914045 citedByCount "16" @default.
- W2892914045 countsByYear W28929140452019 @default.
- W2892914045 countsByYear W28929140452020 @default.
- W2892914045 countsByYear W28929140452021 @default.
- W2892914045 countsByYear W28929140452022 @default.
- W2892914045 countsByYear W28929140452023 @default.
- W2892914045 crossrefType "journal-article" @default.
- W2892914045 hasAuthorship W2892914045A5000811510 @default.
- W2892914045 hasAuthorship W2892914045A5002262798 @default.
- W2892914045 hasAuthorship W2892914045A5003062724 @default.
- W2892914045 hasAuthorship W2892914045A5039987256 @default.
- W2892914045 hasAuthorship W2892914045A5047919770 @default.
- W2892914045 hasAuthorship W2892914045A5057154885 @default.
- W2892914045 hasAuthorship W2892914045A5062919697 @default.
- W2892914045 hasAuthorship W2892914045A5064495395 @default.
- W2892914045 hasAuthorship W2892914045A5087741427 @default.
- W2892914045 hasConcept C149629883 @default.
- W2892914045 hasConcept C162356407 @default.
- W2892914045 hasConcept C179998833 @default.
- W2892914045 hasConcept C185592680 @default.
- W2892914045 hasConcept C205345274 @default.
- W2892914045 hasConcept C2776148806 @default.
- W2892914045 hasConcept C2777230291 @default.
- W2892914045 hasConcept C2779858419 @default.
- W2892914045 hasConcept C43617362 @default.
- W2892914045 hasConcept C4725764 @default.
- W2892914045 hasConcept C556039675 @default.
- W2892914045 hasConcept C71924100 @default.
- W2892914045 hasConceptScore W2892914045C149629883 @default.
- W2892914045 hasConceptScore W2892914045C162356407 @default.
- W2892914045 hasConceptScore W2892914045C179998833 @default.
- W2892914045 hasConceptScore W2892914045C185592680 @default.
- W2892914045 hasConceptScore W2892914045C205345274 @default.
- W2892914045 hasConceptScore W2892914045C2776148806 @default.
- W2892914045 hasConceptScore W2892914045C2777230291 @default.
- W2892914045 hasConceptScore W2892914045C2779858419 @default.
- W2892914045 hasConceptScore W2892914045C43617362 @default.
- W2892914045 hasConceptScore W2892914045C4725764 @default.
- W2892914045 hasConceptScore W2892914045C556039675 @default.
- W2892914045 hasConceptScore W2892914045C71924100 @default.
- W2892914045 hasFunder F4320323484 @default.
- W2892914045 hasFunder F4320326446 @default.
- W2892914045 hasLocation W28929140451 @default.
- W2892914045 hasLocation W28929140452 @default.
- W2892914045 hasOpenAccess W2892914045 @default.
- W2892914045 hasPrimaryLocation W28929140451 @default.
- W2892914045 hasRelatedWork W1993543978 @default.
- W2892914045 hasRelatedWork W2356690386 @default.
- W2892914045 hasRelatedWork W2379120346 @default.
- W2892914045 hasRelatedWork W2387079437 @default.
- W2892914045 hasRelatedWork W2646424694 @default.
- W2892914045 hasRelatedWork W2811333579 @default.
- W2892914045 hasRelatedWork W4250352138 @default.
- W2892914045 hasRelatedWork W745647403 @default.
- W2892914045 hasRelatedWork W2184279991 @default.
- W2892914045 hasRelatedWork W3091448164 @default.
- W2892914045 hasVolume "234" @default.
- W2892914045 isParatext "false" @default.
- W2892914045 isRetracted "false" @default.
- W2892914045 magId "2892914045" @default.
- W2892914045 workType "article" @default.