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• W2892915162 abstract "Background. CrataBL is a protein isolated from Crataeva tapia bark. It has been shown to exhibit several biological properties, including anti-inflammatory, analgesic, antitumor, and insecticidal activities. There are no studies evaluating the role of CrataBL in experimental asthma models. Aim . To evaluate the effects of CrataBL on lung mechanics, inflammation, remodeling, and oxidative stress activation of mice with allergic pulmonary inflammation. Materials and Methods . BALB/c mice (6-7 weeks old, 25-30g) were divided into four groups: nonsensitized and nontreated mice (C group, n=8); ovalbumin- (OVA-) sensitized and nontreated mice (OVA group, n=8); nonsensitized and CrataBL -treated mice (C+CR group, n=8); OVA-sensitized and CrataBL -treated mice (OVA+CR group, n=8). We evaluated hyperresponsiveness to methacholine, bronchoalveolar lavage fluid (BALF), pulmonary inflammation, extracellular matrix remodeling, and oxidative stress markers. Results. CrataBL treatment in OVA-sensitized mice (OVA+CR group) attenuated the following variables compared to OVA-sensitized mice without treatment (OVA group) (all p<0.05): (1) respiratory system resistance (Rrs) and elastance (Ers) after methacholine challenge; (2) total cells, macrophages, polymorphonuclear cells, and lymphocytes in BALF; (3) eosinophils and volume fraction of collagen and elastic fibers in the airway and alveolar wall according to histopathological and morphometry analysis; (4) IL-4-, IL-5-, IL-13-, IL-17-, IFN- γ -, MMP-9-, TIMP-1-, TGF- β -, iNOS-, and NF-kB-positive cells and volume of 8-iso-PGF2 α in airway and alveolar septa according to immunohistochemistry; and (5) IL-4, IL-5, and IFN- γ according to an ELISA. Conclusion. CrataBL contributes to the control of hyperresponsiveness, pulmonary inflammation, extracellular matrix remodeling, and oxidative stress responses in an animal model of chronic allergic pulmonary inflammation." @default.
• W2892915162 created "2018-10-05" @default.
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• W2892915162 date "2018-10-01" @default.
• W2892915162 modified "2023-10-16" @default.
• W2892915162 title "The Plant Proteinase Inhibitor<i>CrataBL</i>Plays a Role in Controlling Asthma Response in Mice" @default.
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• W2892915162 cites W191660614 @default.
• W2892915162 cites W1966288602 @default.
• W2892915162 cites W1966826140 @default.
• W2892915162 cites W1969482433 @default.
• W2892915162 cites W1973209812 @default.
• W2892915162 cites W1976198564 @default.
• W2892915162 cites W1976292850 @default.
• W2892915162 cites W1981644297 @default.
• W2892915162 cites W1983320616 @default.
• W2892915162 cites W1987899489 @default.
• W2892915162 cites W2001654511 @default.
• W2892915162 cites W2009829849 @default.
• W2892915162 cites W2013232307 @default.
• W2892915162 cites W2017780894 @default.
• W2892915162 cites W2021494707 @default.
• W2892915162 cites W2024039234 @default.
• W2892915162 cites W2026711149 @default.
• W2892915162 cites W2030869337 @default.
• W2892915162 cites W2040953590 @default.
• W2892915162 cites W2049038183 @default.
• W2892915162 cites W2052122855 @default.
• W2892915162 cites W2057930810 @default.
• W2892915162 cites W2065941384 @default.
• W2892915162 cites W2067665283 @default.
• W2892915162 cites W2082069763 @default.
• W2892915162 cites W2086201428 @default.
• W2892915162 cites W2096018298 @default.
• W2892915162 cites W2109905579 @default.
• W2892915162 cites W2110664688 @default.
• W2892915162 cites W2134117437 @default.
• W2892915162 cites W2141606210 @default.
• W2892915162 cites W2144944593 @default.
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• W2892915162 cites W2161745512 @default.
• W2892915162 cites W2170330937 @default.
• W2892915162 cites W2205670115 @default.
• W2892915162 cites W2278755260 @default.
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• W2892915162 doi "https://doi.org/10.1155/2018/9274817" @default.
• W2892915162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6188594" @default.
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