FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892915214> ?p ?o ?g. }

• W2892915214 abstract "To conduct a multi-tissue investigation on the penetration and distribution of topical atropine in myopia treatment, and determine if atropine is detectable in the untreated contralateral eye after uniocular instillation.Nine mature New Zealand white rabbits were evenly divided into three groups. Each group was killed at 5, 24 and 72 hr, respectively, following uniocular instillation of 0.05 ml of 1% atropine. Tissues were sampled after enucleation: conjunctiva, sclera, cornea, iris, ciliary body, lens, retina, aqueous, and vitreous humors. The assay for atropine was performed using liquid chromatography-mass spectrometry (LC-MS), and molecular tissue distribution was illustrated using matrix-assisted laser desorption ionization-imaging mass spectrometry (MALDI-IMS) via an independent experiment on murine eyes.At 5 hr, the highest (mean ± SEM) concentration of atropine was detected in the conjunctiva (19.05 ± 5.57 ng/mg, p < 0.05) with a concentration gradient established anteriorly to posteriorly, as supported by MALDI-IMS. At 24 hr, preferential binding of atropine to posterior ocular tissues occurred, demonstrating a reversal of the initial concentration gradient. Atropine has good ocular bioavailability with concentrations of two magnitudes higher than its binding affinity in most tissues at 3 days. Crossing-over of atropine to the untreated eye occurred within 5 hr post-administration.Both transcorneal and transconjunctival-scleral routes are key in atropine absorption. Posterior ocular tissues could be important sites of action by atropine in myopic reduction. In uniocular atropine trials, cross-over effects on the placebo eye should be adjusted to enhance results reliability. Combining the use of LC-MS and MALDI-IMS can be a viable approach in the study of the ocular pharmacokinetics of atropine." @default.
• W2892915214 created "2018-10-05" @default.
• W2892915214 creator A5007551999 @default.
• W2892915214 creator A5008853450 @default.
• W2892915214 creator A5014726730 @default.
• W2892915214 creator A5018009733 @default.
• W2892915214 creator A5036882735 @default.
• W2892915214 creator A5043061995 @default.
• W2892915214 creator A5045929103 @default.
• W2892915214 creator A5046475785 @default.
• W2892915214 date "2018-09-26" @default.
• W2892915214 modified "2023-10-10" @default.
• W2892915214 title "The penetration and distribution of topical atropine in animal ocular tissues" @default.
• W2892915214 cites W108171185 @default.
• W2892915214 cites W118048325 @default.
• W2892915214 cites W122137660 @default.
• W2892915214 cites W1584824855 @default.
• W2892915214 cites W1946168984 @default.
• W2892915214 cites W1966752643 @default.
• W2892915214 cites W1967892728 @default.
• W2892915214 cites W1968092349 @default.
• W2892915214 cites W1971563679 @default.
• W2892915214 cites W1972244086 @default.
• W2892915214 cites W1976996464 @default.
• W2892915214 cites W1977828263 @default.
• W2892915214 cites W1990770500 @default.
• W2892915214 cites W1994487622 @default.
• W2892915214 cites W1995677406 @default.
• W2892915214 cites W1995894795 @default.
• W2892915214 cites W1996853317 @default.
• W2892915214 cites W1998356602 @default.
• W2892915214 cites W2003759790 @default.
• W2892915214 cites W2013204272 @default.
• W2892915214 cites W2017885741 @default.
• W2892915214 cites W2021241776 @default.
• W2892915214 cites W2021560207 @default.
• W2892915214 cites W2023903257 @default.
• W2892915214 cites W2028877695 @default.
• W2892915214 cites W2031671434 @default.
• W2892915214 cites W2032623331 @default.
• W2892915214 cites W2046118526 @default.
• W2892915214 cites W2048285122 @default.
• W2892915214 cites W2052093626 @default.
• W2892915214 cites W2055316773 @default.
• W2892915214 cites W2057971042 @default.
• W2892915214 cites W2062552854 @default.
• W2892915214 cites W2066598121 @default.
• W2892915214 cites W2067464530 @default.
• W2892915214 cites W2070211323 @default.
• W2892915214 cites W2082158170 @default.
• W2892915214 cites W2084692770 @default.
• W2892915214 cites W2085666293 @default.
• W2892915214 cites W2088076000 @default.
• W2892915214 cites W2091764921 @default.
• W2892915214 cites W2115153828 @default.
• W2892915214 cites W2124898817 @default.
• W2892915214 cites W2139077400 @default.
• W2892915214 cites W2142178659 @default.
• W2892915214 cites W2143059963 @default.
• W2892915214 cites W2147101515 @default.
• W2892915214 cites W2150586250 @default.
• W2892915214 cites W2164893966 @default.
• W2892915214 cites W2263395847 @default.
• W2892915214 cites W2322578512 @default.
• W2892915214 cites W2335711157 @default.
• W2892915214 cites W293452553 @default.
• W2892915214 cites W4242772500 @default.
• W2892915214 cites W43396993 @default.
• W2892915214 doi "https://doi.org/10.1111/aos.13889" @default.
• W2892915214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30259687" @default.
• W2892915214 hasPublicationYear "2018" @default.
• W2892915214 type Work @default.
• W2892915214 sameAs 2892915214 @default.
• W2892915214 citedByCount "19" @default.
• W2892915214 countsByYear W28929152142019 @default.
• W2892915214 countsByYear W28929152142020 @default.
• W2892915214 countsByYear W28929152142021 @default.
• W2892915214 countsByYear W28929152142022 @default.
• W2892915214 countsByYear W28929152142023 @default.
• W2892915214 crossrefType "journal-article" @default.
• W2892915214 hasAuthorship W2892915214A5007551999 @default.
• W2892915214 hasAuthorship W2892915214A5008853450 @default.
• W2892915214 hasAuthorship W2892915214A5014726730 @default.
• W2892915214 hasAuthorship W2892915214A5018009733 @default.
• W2892915214 hasAuthorship W2892915214A5036882735 @default.
• W2892915214 hasAuthorship W2892915214A5043061995 @default.
• W2892915214 hasAuthorship W2892915214A5045929103 @default.
• W2892915214 hasAuthorship W2892915214A5046475785 @default.
• W2892915214 hasBestOaLocation W28929152141 @default.
• W2892915214 hasConcept C112705442 @default.
• W2892915214 hasConcept C118487528 @default.
• W2892915214 hasConcept C142724271 @default.
• W2892915214 hasConcept C185592680 @default.
• W2892915214 hasConcept C2775859210 @default.
• W2892915214 hasConcept C2775984611 @default.
• W2892915214 hasConcept C2776882836 @default.
• W2892915214 hasConcept C2777100477 @default.
• W2892915214 hasConcept C2778434524 @default.
• W2892915214 hasConcept C42219234 @default.
• W2892915214 hasConcept C71924100 @default.

• next