FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892917010> ?p ?o ?g. }

• W2892917010 endingPage "112" @default.
• W2892917010 startingPage "103" @default.
• W2892917010 abstract "BackgroundHLA-B*35 is an HLA allele associated with rapid progression to AIDS. However, a mechanism underlying the detrimental effect of HLA-B*35 on disease outcome remains unknown. Recent studies demonstrated that most prevalent subtype HLA-B*35:01 is a detrimental allele in HIV-1 clade B-infected individuals. We here investigated the effect of mutations within the epitopes on HLA-B*35:01-restricted CD8+ T cells having abilities to suppress HIV-1 replication.MethodsWe analyzed 16 HLA-B*35:01-restricted epitope-specific T cells in 63 HIV-1 clade B-infected Japanese B*35:01+ individuals and identified HLA-B*35:01-restricted CD8+ T cells having abilities to suppress HIV-1 replication. We further analyzed the effect of HLA-associated mutations on the ability of these T cells.FindingsThe breadth of T cell responses to 4 epitopes was inversely associated with plasma viral load (pVL). However, the accumulation of an Y135F mutation in NefYF9 out of the 4 epitopes, which is selected by HLA-A*24:02-restricted T cells, affected the ability of YF9-specific T cells to suppress HIV-1 replication. HLA-B*35:01+ individuals harboring this mutation had much higher pVL than those without it. YF9-specific T cells failed to suppress replication of the Y135F mutant in vitro. These results indicate that this mutation impairs suppression of HIV-1 replication by YF9-specific T cells.InterpretationThese findings indicate that the Y135F mutation is a key factor underlying the detrimental effect of HLA-B*35:01 on disease outcomes in HIV-1 clade B-infected individuals.FundGrants-in-aid for AIDS Research from AMED and for scientific research from the Ministry of Education, Science, Sports, and Culture, Japan." @default.
• W2892917010 created "2018-10-05" @default.
• W2892917010 creator A5002199680 @default.
• W2892917010 creator A5029414324 @default.
• W2892917010 creator A5035598800 @default.
• W2892917010 creator A5036924243 @default.
• W2892917010 creator A5039263624 @default.
• W2892917010 creator A5069648009 @default.
• W2892917010 creator A5072097342 @default.
• W2892917010 creator A5078546233 @default.
• W2892917010 creator A5079661998 @default.
• W2892917010 date "2018-10-01" @default.
• W2892917010 modified "2023-10-18" @default.
• W2892917010 title "Impact of a single HLA-A*24:02-associated escape mutation on the detrimental effect of HLA-B*35:01 in HIV-1 control" @default.
• W2892917010 cites W1560103427 @default.
• W2892917010 cites W1601298625 @default.
• W2892917010 cites W1601671592 @default.
• W2892917010 cites W1714666634 @default.
• W2892917010 cites W1887429446 @default.
• W2892917010 cites W1928100000 @default.
• W2892917010 cites W1932388426 @default.
• W2892917010 cites W1963813930 @default.
• W2892917010 cites W1967018933 @default.
• W2892917010 cites W1967714946 @default.
• W2892917010 cites W1971877271 @default.
• W2892917010 cites W1980429964 @default.
• W2892917010 cites W1992550850 @default.
• W2892917010 cites W1995453338 @default.
• W2892917010 cites W2002530218 @default.
• W2892917010 cites W2007021820 @default.
• W2892917010 cites W2011541285 @default.
• W2892917010 cites W2014518458 @default.
• W2892917010 cites W2026444780 @default.
• W2892917010 cites W2035555649 @default.
• W2892917010 cites W2045551237 @default.
• W2892917010 cites W2048831587 @default.
• W2892917010 cites W2048999843 @default.
• W2892917010 cites W2054961553 @default.
• W2892917010 cites W2061314973 @default.
• W2892917010 cites W20663261 @default.
• W2892917010 cites W2067069532 @default.
• W2892917010 cites W2070676224 @default.
• W2892917010 cites W2071260450 @default.
• W2892917010 cites W2071666076 @default.
• W2892917010 cites W2072132286 @default.
• W2892917010 cites W2075906228 @default.
• W2892917010 cites W2078844183 @default.
• W2892917010 cites W2090630729 @default.
• W2892917010 cites W2096130477 @default.
• W2892917010 cites W2106915606 @default.
• W2892917010 cites W2109130469 @default.
• W2892917010 cites W2111259757 @default.
• W2892917010 cites W2115824680 @default.
• W2892917010 cites W2123584222 @default.
• W2892917010 cites W2125796652 @default.
• W2892917010 cites W2128411013 @default.
• W2892917010 cites W2130520973 @default.
• W2892917010 cites W2134084635 @default.
• W2892917010 cites W2141910765 @default.
• W2892917010 cites W2142405752 @default.
• W2892917010 cites W2152453984 @default.
• W2892917010 cites W2153778605 @default.
• W2892917010 cites W2159352573 @default.
• W2892917010 cites W2164953896 @default.
• W2892917010 cites W2167344136 @default.
• W2892917010 cites W2230157244 @default.
• W2892917010 cites W2314456041 @default.
• W2892917010 cites W2320418919 @default.
• W2892917010 cites W2405965265 @default.
• W2892917010 cites W2559663423 @default.
• W2892917010 cites W2773359593 @default.
• W2892917010 cites W2810189589 @default.
• W2892917010 doi "https://doi.org/10.1016/j.ebiom.2018.09.022" @default.
• W2892917010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6197679" @default.
• W2892917010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30249546" @default.
• W2892917010 hasPublicationYear "2018" @default.
• W2892917010 type Work @default.
• W2892917010 sameAs 2892917010 @default.
• W2892917010 citedByCount "9" @default.
• W2892917010 countsByYear W28929170102020 @default.
• W2892917010 countsByYear W28929170102021 @default.
• W2892917010 countsByYear W28929170102022 @default.
• W2892917010 crossrefType "journal-article" @default.
• W2892917010 hasAuthorship W2892917010A5002199680 @default.
• W2892917010 hasAuthorship W2892917010A5029414324 @default.
• W2892917010 hasAuthorship W2892917010A5035598800 @default.
• W2892917010 hasAuthorship W2892917010A5036924243 @default.
• W2892917010 hasAuthorship W2892917010A5039263624 @default.
• W2892917010 hasAuthorship W2892917010A5069648009 @default.
• W2892917010 hasAuthorship W2892917010A5072097342 @default.
• W2892917010 hasAuthorship W2892917010A5078546233 @default.
• W2892917010 hasAuthorship W2892917010A5079661998 @default.
• W2892917010 hasBestOaLocation W28929170101 @default.
• W2892917010 hasConcept C104317684 @default.
• W2892917010 hasConcept C140704245 @default.
• W2892917010 hasConcept C147483822 @default.
• W2892917010 hasConcept C154317977 @default.
• W2892917010 hasConcept C159047783 @default.

• next