Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892922161> ?p ?o ?g. }
- W2892922161 abstract "Our previous in vitro studies revealed that histamine via histamine the H4-receptors (H4R), as compared to other stimuli, such as eotaxin or formylpeptides, rather partially activates eosinophilic granulocytes (eosinophils). In order to evaluate the H4R-mediated activation of eosinophils in vivo, we employed dextran sodium sulfate (DSS)-induced colitis in mice, closely resembling human ulcerative colitis (UC), which is largely characterized by a local eosinophilic infiltration of the colon. IL-5-deficient BALB/c mice served as a model with reduced endogenous numbers of eosinophils, in which wild-type (H4R+/+) or H4R-deficient (H4R-/-) eosinophils were adoptively transferred during the course of DSS-induced colitis. During the 1-week observation period, transfer of eosinophils transiently reversed the acute clinical colitis-like phenotype (body weight loss, perianal bleeding, soft stool consistency) resulting from IL-5-deficiency. This reversion was significantly more pronounced upon transfer of eosinophils from H4R+/+ mice as compared to those from H4R-/- mice. Already at the end of the observation period, the clinical effects of the transfer of H4R+/+ and H4R-/- eosinophils became similar, as were the results of the histological examination of the cola and the analyses of cytokine production in cola and in re-stimulated lymph node cells performed at this time. Thus, analyzing clinical and pathological parameters representative of colitis in this model, we demonstrate that as well as in vitro, also in vivo histamine via the H4R only partially activates eosinophils." @default.
- W2892922161 created "2018-10-05" @default.
- W2892922161 creator A5006177064 @default.
- W2892922161 creator A5040439170 @default.
- W2892922161 creator A5044768118 @default.
- W2892922161 creator A5047218507 @default.
- W2892922161 date "2018-09-25" @default.
- W2892922161 modified "2023-10-12" @default.
- W2892922161 title "In vivo Evidence for Partial Activation of Eosinophils via the Histamine H4-Receptor: Adoptive Transfer Experiments Using Eosinophils From H4R−/− and H4R+/+ Mice" @default.
- W2892922161 cites W106537088 @default.
- W2892922161 cites W1530437552 @default.
- W2892922161 cites W1686669900 @default.
- W2892922161 cites W1813646352 @default.
- W2892922161 cites W1832849100 @default.
- W2892922161 cites W1954354169 @default.
- W2892922161 cites W1956325971 @default.
- W2892922161 cites W1978098394 @default.
- W2892922161 cites W1981834612 @default.
- W2892922161 cites W1986803622 @default.
- W2892922161 cites W2012087980 @default.
- W2892922161 cites W2013398994 @default.
- W2892922161 cites W2026140150 @default.
- W2892922161 cites W2041392997 @default.
- W2892922161 cites W2041937465 @default.
- W2892922161 cites W2043027238 @default.
- W2892922161 cites W2054197038 @default.
- W2892922161 cites W2055527205 @default.
- W2892922161 cites W2056521778 @default.
- W2892922161 cites W2063731747 @default.
- W2892922161 cites W2068966583 @default.
- W2892922161 cites W2072847361 @default.
- W2892922161 cites W2078621117 @default.
- W2892922161 cites W2083987719 @default.
- W2892922161 cites W2084013653 @default.
- W2892922161 cites W2085013775 @default.
- W2892922161 cites W2086545512 @default.
- W2892922161 cites W2091899538 @default.
- W2892922161 cites W2092009055 @default.
- W2892922161 cites W2110075931 @default.
- W2892922161 cites W2110216080 @default.
- W2892922161 cites W2113620103 @default.
- W2892922161 cites W2122278985 @default.
- W2892922161 cites W2129259968 @default.
- W2892922161 cites W2167179436 @default.
- W2892922161 cites W2344997484 @default.
- W2892922161 cites W2398327881 @default.
- W2892922161 cites W2414599205 @default.
- W2892922161 cites W2414683332 @default.
- W2892922161 cites W2519114816 @default.
- W2892922161 cites W2602717122 @default.
- W2892922161 cites W2785786024 @default.
- W2892922161 doi "https://doi.org/10.3389/fimmu.2018.02119" @default.
- W2892922161 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6167465" @default.
- W2892922161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30319608" @default.
- W2892922161 hasPublicationYear "2018" @default.
- W2892922161 type Work @default.
- W2892922161 sameAs 2892922161 @default.
- W2892922161 citedByCount "7" @default.
- W2892922161 countsByYear W28929221612020 @default.
- W2892922161 countsByYear W28929221612021 @default.
- W2892922161 countsByYear W28929221612023 @default.
- W2892922161 crossrefType "journal-article" @default.
- W2892922161 hasAuthorship W2892922161A5006177064 @default.
- W2892922161 hasAuthorship W2892922161A5040439170 @default.
- W2892922161 hasAuthorship W2892922161A5044768118 @default.
- W2892922161 hasAuthorship W2892922161A5047218507 @default.
- W2892922161 hasBestOaLocation W28929221611 @default.
- W2892922161 hasConcept C1122143 @default.
- W2892922161 hasConcept C126322002 @default.
- W2892922161 hasConcept C150903083 @default.
- W2892922161 hasConcept C170493617 @default.
- W2892922161 hasConcept C181901479 @default.
- W2892922161 hasConcept C185592680 @default.
- W2892922161 hasConcept C203014093 @default.
- W2892922161 hasConcept C207001950 @default.
- W2892922161 hasConcept C2775862500 @default.
- W2892922161 hasConcept C2776042228 @default.
- W2892922161 hasConcept C2776885963 @default.
- W2892922161 hasConcept C2777037409 @default.
- W2892922161 hasConcept C2778690821 @default.
- W2892922161 hasConcept C30862142 @default.
- W2892922161 hasConcept C34400551 @default.
- W2892922161 hasConcept C71924100 @default.
- W2892922161 hasConcept C74172505 @default.
- W2892922161 hasConcept C86803240 @default.
- W2892922161 hasConceptScore W2892922161C1122143 @default.
- W2892922161 hasConceptScore W2892922161C126322002 @default.
- W2892922161 hasConceptScore W2892922161C150903083 @default.
- W2892922161 hasConceptScore W2892922161C170493617 @default.
- W2892922161 hasConceptScore W2892922161C181901479 @default.
- W2892922161 hasConceptScore W2892922161C185592680 @default.
- W2892922161 hasConceptScore W2892922161C203014093 @default.
- W2892922161 hasConceptScore W2892922161C207001950 @default.
- W2892922161 hasConceptScore W2892922161C2775862500 @default.
- W2892922161 hasConceptScore W2892922161C2776042228 @default.
- W2892922161 hasConceptScore W2892922161C2776885963 @default.
- W2892922161 hasConceptScore W2892922161C2777037409 @default.
- W2892922161 hasConceptScore W2892922161C2778690821 @default.
- W2892922161 hasConceptScore W2892922161C30862142 @default.
- W2892922161 hasConceptScore W2892922161C34400551 @default.