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- W2892928169 abstract "Cellular protein homeostasis is maintained by two major degradation pathways, namely the ubiquitin-proteasome system (UPS) and autophagy. Until recently, the UPS and autophagy were considered to be largely independent systems targeting proteins for degradation in the proteasome and lysosome, respectively. However, the identification of crucial roles of molecular players such as ubiquitin and p62 in both of these pathways as well as the observation that blocking the UPS affects autophagy flux and vice versa has generated interest in studying crosstalk between these pathways. Here, we critically review the current understanding of how the UPS and autophagy execute coordinated protein degradation at the molecular level, and shed light on our recent findings indicating an important role of an autophagy-associated transmembrane protein EI24 as a bridging molecule between the UPS and autophagy that functions by regulating the degradation of several E3 ligases with Really Interesting New Gene (RING)-domains." @default.
- W2892928169 created "2018-10-05" @default.
- W2892928169 creator A5016389594 @default.
- W2892928169 creator A5028619599 @default.
- W2892928169 creator A5079763798 @default.
- W2892928169 creator A5082881561 @default.
- W2892928169 date "2017-12-31" @default.
- W2892928169 modified "2023-10-16" @default.
- W2892928169 title "Emerging Paradigm of Crosstalk between Autophagy and the Ubiquitin-Proteasome System." @default.
- W2892928169 cites W1513849811 @default.
- W2892928169 cites W1514816941 @default.
- W2892928169 cites W1547976002 @default.
- W2892928169 cites W1581353228 @default.
- W2892928169 cites W1590553747 @default.
- W2892928169 cites W1598865329 @default.
- W2892928169 cites W1890105955 @default.
- W2892928169 cites W1918329266 @default.
- W2892928169 cites W1969342645 @default.
- W2892928169 cites W1973458262 @default.
- W2892928169 cites W1973729541 @default.
- W2892928169 cites W1973921769 @default.
- W2892928169 cites W1974279922 @default.
- W2892928169 cites W1979717090 @default.
- W2892928169 cites W1979762856 @default.
- W2892928169 cites W1981551685 @default.
- W2892928169 cites W1982732854 @default.
- W2892928169 cites W1986040594 @default.
- W2892928169 cites W1986911829 @default.
- W2892928169 cites W1994939674 @default.
- W2892928169 cites W1996138273 @default.
- W2892928169 cites W2001591494 @default.
- W2892928169 cites W2005597525 @default.
- W2892928169 cites W2005997790 @default.
- W2892928169 cites W2007455466 @default.
- W2892928169 cites W2013339424 @default.
- W2892928169 cites W2018636808 @default.
- W2892928169 cites W2023100224 @default.
- W2892928169 cites W2032700869 @default.
- W2892928169 cites W2034042027 @default.
- W2892928169 cites W2034130805 @default.
- W2892928169 cites W2034252839 @default.
- W2892928169 cites W2038976751 @default.
- W2892928169 cites W2044621729 @default.
- W2892928169 cites W2046250764 @default.
- W2892928169 cites W2047979617 @default.
- W2892928169 cites W2048098925 @default.
- W2892928169 cites W2048737347 @default.
- W2892928169 cites W2055214702 @default.
- W2892928169 cites W2058238065 @default.
- W2892928169 cites W2060776482 @default.
- W2892928169 cites W2062527379 @default.
- W2892928169 cites W2069934833 @default.
- W2892928169 cites W2074900534 @default.
- W2892928169 cites W2079428226 @default.
- W2892928169 cites W2081057817 @default.
- W2892928169 cites W2091250038 @default.
- W2892928169 cites W2097830998 @default.
- W2892928169 cites W2099429838 @default.
- W2892928169 cites W2111357564 @default.
- W2892928169 cites W2119399459 @default.
- W2892928169 cites W2121077787 @default.
- W2892928169 cites W2121429373 @default.
- W2892928169 cites W2124105006 @default.
- W2892928169 cites W2128677681 @default.
- W2892928169 cites W2130979925 @default.
- W2892928169 cites W2135574023 @default.
- W2892928169 cites W2139363724 @default.
- W2892928169 cites W2146887271 @default.
- W2892928169 cites W2150027419 @default.
- W2892928169 cites W2152231829 @default.
- W2892928169 cites W2157574579 @default.
- W2892928169 cites W2239175614 @default.
- W2892928169 cites W2283287858 @default.
- W2892928169 cites W2466321927 @default.
- W2892928169 cites W2484263890 @default.
- W2892928169 cites W2485590864 @default.
- W2892928169 cites W2517046579 @default.
- W2892928169 cites W2558938931 @default.
- W2892928169 cites W2561943186 @default.
- W2892928169 cites W2594299422 @default.
- W2892928169 cites W2611401896 @default.
- W2892928169 cites W2615829409 @default.
- W2892928169 cites W2620578360 @default.
- W2892928169 cites W2625470034 @default.
- W2892928169 cites W2735235732 @default.
- W2892928169 cites W2738996050 @default.
- W2892928169 cites W2756601401 @default.
- W2892928169 cites W775311174 @default.
- W2892928169 doi "https://doi.org/10.14348/molcells.2017.0226" @default.
- W2892928169 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5750708" @default.
- W2892928169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29237114" @default.
- W2892928169 hasPublicationYear "2017" @default.
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