FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892932086> ?p ?o ?g. }

• W2892932086 abstract "Responses of sympathetic nerve activity and arterial blood pressure are augmented during activation of the exercise pressor reflex in rats with femoral artery occlusion. The present study examined the role played by pro-inflammatory tumor necrosis factor-α (TNF-α) in regulating augmented sympathetic responsiveness induced by stimulation of muscle metabolic receptors and static muscle contraction following 72 hours of femoral artery occlusion. We first observed that the levels of TNF-α and protein expression of TNF-α receptor type 1 (TNFR1) were increased in the dorsal root ganglion (DRG) of hindlimbs with femoral artery occlusion. Note that TNF-α was observed within DRG neurons of C-fiber afferent nerves. Capsaicin (TRPV1 agonist) and AITC (TRPA1 agonist) were injected into arterial blood supply of the hindlimbs to stimulate metabolically sensitive thin-fiber muscle afferents. The effects of these injections on the sympathetic and pressor responses were further examined in control rats and rats with femoral artery occlusion. As TNF-α synthesis suppressor pentoxifylline (PTX) was previously administered into the hindlimb with femoral artery occlusion, sympathetic and pressor responses induced by capsaicin and AITC were attenuated. In occluded rats, PTX also attenuated the exaggeration of blood pressure response induced by muscle contraction, but not by passive tendon stretch. Overall, the results suggest that TNF-α plays a role in modulating exaggerated sympathetic nervous activity via the metabolic component of the exercise pressor reflex when the hindlimb muscles are ischemic in peripheral arterial disease." @default.
• W2892932086 created "2018-10-05" @default.
• W2892932086 creator A5016647517 @default.
• W2892932086 creator A5031153639 @default.
• W2892932086 creator A5046380471 @default.
• W2892932086 date "2018-10-15" @default.
• W2892932086 modified "2023-10-14" @default.
• W2892932086 title "Role of TNF-α in Regulating the Exercise Pressor Reflex in Rats With Femoral Artery Occlusion" @default.
• W2892932086 cites W1608557519 @default.
• W2892932086 cites W1754998069 @default.
• W2892932086 cites W1800679924 @default.
• W2892932086 cites W1818631042 @default.
• W2892932086 cites W1837386705 @default.
• W2892932086 cites W1900683323 @default.
• W2892932086 cites W1959152155 @default.
• W2892932086 cites W1967918550 @default.
• W2892932086 cites W1983602530 @default.
• W2892932086 cites W2001024611 @default.
• W2892932086 cites W2008762236 @default.
• W2892932086 cites W2012212705 @default.
• W2892932086 cites W2021406578 @default.
• W2892932086 cites W2027068762 @default.
• W2892932086 cites W2027709306 @default.
• W2892932086 cites W2029227926 @default.
• W2892932086 cites W2029406069 @default.
• W2892932086 cites W2034721936 @default.
• W2892932086 cites W2042414597 @default.
• W2892932086 cites W2048288697 @default.
• W2892932086 cites W2063311461 @default.
• W2892932086 cites W2065027534 @default.
• W2892932086 cites W2065229769 @default.
• W2892932086 cites W2069681479 @default.
• W2892932086 cites W2069763385 @default.
• W2892932086 cites W2073293886 @default.
• W2892932086 cites W2082309778 @default.
• W2892932086 cites W2084970316 @default.
• W2892932086 cites W2087252312 @default.
• W2892932086 cites W2087633509 @default.
• W2892932086 cites W2095971269 @default.
• W2892932086 cites W2107884320 @default.
• W2892932086 cites W2110880731 @default.
• W2892932086 cites W2118624477 @default.
• W2892932086 cites W2119813498 @default.
• W2892932086 cites W2125838286 @default.
• W2892932086 cites W2126720320 @default.
• W2892932086 cites W2130248772 @default.
• W2892932086 cites W2134956423 @default.
• W2892932086 cites W2136094484 @default.
• W2892932086 cites W2136198755 @default.
• W2892932086 cites W2137646952 @default.
• W2892932086 cites W2147461380 @default.
• W2892932086 cites W2163463787 @default.
• W2892932086 cites W2171742223 @default.
• W2892932086 cites W2176489849 @default.
• W2892932086 cites W2297676769 @default.
• W2892932086 cites W2333361253 @default.
• W2892932086 cites W2412416731 @default.
• W2892932086 cites W2463163549 @default.
• W2892932086 cites W2541941721 @default.
• W2892932086 cites W2901396904 @default.
• W2892932086 cites W4239435043 @default.
• W2892932086 cites W2417925644 @default.
• W2892932086 doi "https://doi.org/10.3389/fphys.2018.01461" @default.
• W2892932086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6196241" @default.
• W2892932086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30374312" @default.
• W2892932086 hasPublicationYear "2018" @default.
• W2892932086 type Work @default.
• W2892932086 sameAs 2892932086 @default.
• W2892932086 citedByCount "12" @default.
• W2892932086 countsByYear W28929320862020 @default.
• W2892932086 countsByYear W28929320862021 @default.
• W2892932086 countsByYear W28929320862022 @default.
• W2892932086 countsByYear W28929320862023 @default.
• W2892932086 crossrefType "journal-article" @default.
• W2892932086 hasAuthorship W2892932086A5016647517 @default.
• W2892932086 hasAuthorship W2892932086A5031153639 @default.
• W2892932086 hasAuthorship W2892932086A5046380471 @default.
• W2892932086 hasBestOaLocation W28929320861 @default.
• W2892932086 hasConcept C126322002 @default.
• W2892932086 hasConcept C134018914 @default.
• W2892932086 hasConcept C155164980 @default.
• W2892932086 hasConcept C160145004 @default.
• W2892932086 hasConcept C170493617 @default.
• W2892932086 hasConcept C2776533406 @default.
• W2892932086 hasConcept C2778938600 @default.
• W2892932086 hasConcept C2779723990 @default.
• W2892932086 hasConcept C42219234 @default.
• W2892932086 hasConcept C51738704 @default.
• W2892932086 hasConcept C71924100 @default.
• W2892932086 hasConcept C83974742 @default.
• W2892932086 hasConcept C84393581 @default.
• W2892932086 hasConceptScore W2892932086C126322002 @default.
• W2892932086 hasConceptScore W2892932086C134018914 @default.
• W2892932086 hasConceptScore W2892932086C155164980 @default.
• W2892932086 hasConceptScore W2892932086C160145004 @default.
• W2892932086 hasConceptScore W2892932086C170493617 @default.
• W2892932086 hasConceptScore W2892932086C2776533406 @default.
• W2892932086 hasConceptScore W2892932086C2778938600 @default.
• W2892932086 hasConceptScore W2892932086C2779723990 @default.
• W2892932086 hasConceptScore W2892932086C42219234 @default.

• next