Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892937951> ?p ?o ?g. }
- W2892937951 abstract "Neurodegenerative processes in the elderly damage the brain, leading to progressive, incapacitating cognitive, behavioral, and motor dysfunctions which culminate in dementia. Fully manifest dementia is likely to be preceded by the presence of neurological signs, which could serve as early determinants of dementia and predictors of mortality. The aims of this study were to assess the construct validity of a neurological battery assessed among older adults living in Latin America, and to test the association of groups of neurological signs with dementia cross-sectionally, and mortality longitudinally.The 10/66 Dementia Research Group collected information on neurological symptoms via the NEUROEX assessment in population based surveys of older adults living in low and middle-income countries. Data from 10,856 adults participating in the baseline assessment of the 10/66 study and living in Cuba, Dominican Republic, Peru, Venezuela and Mexico were analysed. Exploratory and confirmatory analysis were used to explore dimensionality of neurological symptoms. Poisson regression analyses were used to link groups of neurological signs with dementia at baseline. Cox hazard regression models were used to explore the predictive validity of neurological signs with mortality at follow up.Exploratory and confirmatory factor analyses revealed four dimensions of neurological signs, which are associated with lesions of specific brain regions. The identified factors showed consistency with groups of neurological signs such as frontal, cerebellar, extrapyramidal, and more generalized gait disturbance signs. Regression analyses revealed that all groups of neurological signs were positively associated with dementia at baseline and predicted mortality at follow up.Our findings support the construct and predictive validity of the NEUROEX assessment, linking neurological and gait impairments with dementia at baseline, and with mortality at follow up among older adults living in five Latin American countries." @default.
- W2892937951 created "2018-10-05" @default.
- W2892937951 creator A5018132997 @default.
- W2892937951 creator A5027789862 @default.
- W2892937951 creator A5051774516 @default.
- W2892937951 creator A5076005488 @default.
- W2892937951 creator A5076751707 @default.
- W2892937951 date "2018-10-03" @default.
- W2892937951 modified "2023-10-07" @default.
- W2892937951 title "Neurological signs as early determinants of dementia and predictors of mortality among older adults in Latin America: a 10/66 study using the NEUROEX assessment" @default.
- W2892937951 cites W1783087400 @default.
- W2892937951 cites W1971083033 @default.
- W2892937951 cites W1972403950 @default.
- W2892937951 cites W1978232458 @default.
- W2892937951 cites W1985157949 @default.
- W2892937951 cites W1988879672 @default.
- W2892937951 cites W1993571512 @default.
- W2892937951 cites W1998204074 @default.
- W2892937951 cites W2005072240 @default.
- W2892937951 cites W2009469036 @default.
- W2892937951 cites W2014543370 @default.
- W2892937951 cites W2023611349 @default.
- W2892937951 cites W2025921730 @default.
- W2892937951 cites W2033336979 @default.
- W2892937951 cites W2036400270 @default.
- W2892937951 cites W2040429461 @default.
- W2892937951 cites W2046343663 @default.
- W2892937951 cites W2048145302 @default.
- W2892937951 cites W2065317970 @default.
- W2892937951 cites W2070692762 @default.
- W2892937951 cites W2076091312 @default.
- W2892937951 cites W2084471425 @default.
- W2892937951 cites W2085878517 @default.
- W2892937951 cites W2092705208 @default.
- W2892937951 cites W2095678359 @default.
- W2892937951 cites W2098082628 @default.
- W2892937951 cites W2098895682 @default.
- W2892937951 cites W2100484216 @default.
- W2892937951 cites W2140656279 @default.
- W2892937951 cites W2144476887 @default.
- W2892937951 cites W2149007077 @default.
- W2892937951 cites W2159917466 @default.
- W2892937951 cites W2160819746 @default.
- W2892937951 cites W2171250577 @default.
- W2892937951 cites W2176845058 @default.
- W2892937951 cites W2177886641 @default.
- W2892937951 cites W2289951340 @default.
- W2892937951 cites W2338170813 @default.
- W2892937951 cites W2346773485 @default.
- W2892937951 cites W2437840001 @default.
- W2892937951 cites W3023861144 @default.
- W2892937951 cites W4241651664 @default.
- W2892937951 cites W4300611712 @default.
- W2892937951 cites W2033674820 @default.
- W2892937951 doi "https://doi.org/10.1186/s12883-018-1167-4" @default.
- W2892937951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6168999" @default.
- W2892937951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30285663" @default.
- W2892937951 hasPublicationYear "2018" @default.
- W2892937951 type Work @default.
- W2892937951 sameAs 2892937951 @default.
- W2892937951 citedByCount "7" @default.
- W2892937951 countsByYear W28929379512020 @default.
- W2892937951 countsByYear W28929379512021 @default.
- W2892937951 countsByYear W28929379512022 @default.
- W2892937951 countsByYear W28929379512023 @default.
- W2892937951 crossrefType "journal-article" @default.
- W2892937951 hasAuthorship W2892937951A5018132997 @default.
- W2892937951 hasAuthorship W2892937951A5027789862 @default.
- W2892937951 hasAuthorship W2892937951A5051774516 @default.
- W2892937951 hasAuthorship W2892937951A5076005488 @default.
- W2892937951 hasAuthorship W2892937951A5076751707 @default.
- W2892937951 hasBestOaLocation W28929379511 @default.
- W2892937951 hasConcept C105795698 @default.
- W2892937951 hasConcept C118552586 @default.
- W2892937951 hasConcept C126322002 @default.
- W2892937951 hasConcept C16568411 @default.
- W2892937951 hasConcept C187212893 @default.
- W2892937951 hasConcept C2779134260 @default.
- W2892937951 hasConcept C2779483572 @default.
- W2892937951 hasConcept C2780168130 @default.
- W2892937951 hasConcept C2908647359 @default.
- W2892937951 hasConcept C33923547 @default.
- W2892937951 hasConcept C40722632 @default.
- W2892937951 hasConcept C70410870 @default.
- W2892937951 hasConcept C71104824 @default.
- W2892937951 hasConcept C71924100 @default.
- W2892937951 hasConcept C73269764 @default.
- W2892937951 hasConcept C74909509 @default.
- W2892937951 hasConcept C99454951 @default.
- W2892937951 hasConceptScore W2892937951C105795698 @default.
- W2892937951 hasConceptScore W2892937951C118552586 @default.
- W2892937951 hasConceptScore W2892937951C126322002 @default.
- W2892937951 hasConceptScore W2892937951C16568411 @default.
- W2892937951 hasConceptScore W2892937951C187212893 @default.
- W2892937951 hasConceptScore W2892937951C2779134260 @default.
- W2892937951 hasConceptScore W2892937951C2779483572 @default.
- W2892937951 hasConceptScore W2892937951C2780168130 @default.
- W2892937951 hasConceptScore W2892937951C2908647359 @default.
- W2892937951 hasConceptScore W2892937951C33923547 @default.
- W2892937951 hasConceptScore W2892937951C40722632 @default.