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- W2892942916 abstract "Introduction: Mass spectrometry imaging (MSI) techniques are nowadays widely used to obtain spatially resolved metabolite information from biological tissues. Since (phospho)lipids occur in all animal tissues and are very sensitively detectable, they are often in the focus of such studies. This particularly applies for phosphatidylcholines (PC) which are very sensitively detectable as positive ions due to the permanent positive charge of their choline headgroup.Areas covered: After a short introduction of lipid species occurring in biological systems and approaches normally used to obtain spatially resolved mass spectra (with the focus on matrix-assisted laser desorption/ionization coupled to time-of-flight (MALDI-TOF) MSI) a survey will be given which diseases have so far been characterized by changes of the PC composition.Expert commentary: Since PC species are very sensitively detectable by MS, sensitivity is not a major issue. However, spatial resolution is still limited and cellular dimensions can be hardly resolved by MALDI-TOF MSI, which is a critical point of the available approaches. Due to lacks of reproducibility and standardization further development is required." @default.
- W2892942916 created "2018-10-05" @default.
- W2892942916 creator A5008265816 @default.
- W2892942916 creator A5010876048 @default.
- W2892942916 creator A5022722417 @default.
- W2892942916 creator A5075537850 @default.
- W2892942916 date "2018-09-28" @default.
- W2892942916 modified "2023-10-02" @default.
- W2892942916 title "Visualizing phosphatidylcholine via mass spectrometry imaging: relevance to human health" @default.
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- W2892942916 doi "https://doi.org/10.1080/14789450.2018.1526679" @default.
- W2892942916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30241449" @default.
- W2892942916 hasPublicationYear "2018" @default.
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